The critical fetal stage for maternal manganese exposure

Ming Song Tsai, Kai Wei Liao, Chia Huang Chang, Ling Chu Chien, I. Fang Mao, Yen An Tsai, Mei Lien Chen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Prenatal exposure and the health effects of that exposure have been intensively studied for a variety of environmental pollutants and trace elements. However, few studies have compared susceptibilities among the three trimesters of gestation. Manganese (Mn) is a naturally occurring and abundant trace element in the environment. Although the effects of Mn on animals are well documented, knowledge of the effects of Mn exposure on pregnant women and fetuses remains limited. A longitudinal study was conducted by collecting blood samples during all three trimesters, and Mn exposure was completely characterized during gestation. The aims of this study were to examine the effects of maternal Mn exposure on neonatal birth outcomes and to explore the critical stage of these effects.In total, 38, 76 and 76 samples were obtained from singleton pregnant women in their first, second and third trimesters, respectively. The cohort of pregnant women was selected at a medical center in northern Taiwan. Erythrocyte samples were collected during the first, second and third trimesters of gestation. Erythrocyte Mn concentrations were measured by inductively coupled plasma mass spectrometry. Neonatal birth outcomes were evaluated immediately after delivery. A multivariate regression model was used to determine the associations between maternal Mn levels in erythrocytes in each trimester and neonatal birth outcomes.The geometric mean concentrations of Mn were 2.93. μg/dL, 3.96. μg/dL and 4.41. μg/dL in the first, second and third trimesters, respectively. After adjusting for potential confounders, a consistently negative association was found between maternal Mn levels throughout the three trimesters and birth outcomes. Log-transformed Mn levels in maternal erythrocytes in the second trimester were significantly associated with neonatal birth weight, head and chest circumferences, respectively (. β=-556.98. g, p=0.038; β=-1.87. cm, p=0.045; β=-2.74. cm, p=0.024). Despite the limited sample size in the first trimester, negative effects of maternal Mn levels on birth weight (. β=-1108.95. g, p

Original languageEnglish
Pages (from-to)215-221
Number of pages7
JournalEnvironmental Research
Volume137
DOIs
Publication statusPublished - Feb 1 2015

Fingerprint

Maternal Exposure
Manganese
manganese
Second Pregnancy Trimester
First Pregnancy Trimester
Third Pregnancy Trimester
Erythrocytes
Mothers
pregnancy
Parturition
Pregnant Women
Trace Elements
Birth Weight
Pregnancy
exposure
trace element
Inductively coupled plasma mass spectrometry
Environmental Pollutants
Taiwan
Sample Size

Keywords

  • Birth outcomes
  • Birth weight
  • Chest circumference
  • Critical stage of pregnancy exposure
  • Erythrocyte manganese
  • Head circumference

ASJC Scopus subject areas

  • Environmental Science(all)
  • Biochemistry
  • Medicine(all)

Cite this

The critical fetal stage for maternal manganese exposure. / Tsai, Ming Song; Liao, Kai Wei; Chang, Chia Huang; Chien, Ling Chu; Mao, I. Fang; Tsai, Yen An; Chen, Mei Lien.

In: Environmental Research, Vol. 137, 01.02.2015, p. 215-221.

Research output: Contribution to journalArticle

Tsai, Ming Song ; Liao, Kai Wei ; Chang, Chia Huang ; Chien, Ling Chu ; Mao, I. Fang ; Tsai, Yen An ; Chen, Mei Lien. / The critical fetal stage for maternal manganese exposure. In: Environmental Research. 2015 ; Vol. 137. pp. 215-221.
@article{479b147aee9b427f9a2a909de500343b,
title = "The critical fetal stage for maternal manganese exposure",
abstract = "Prenatal exposure and the health effects of that exposure have been intensively studied for a variety of environmental pollutants and trace elements. However, few studies have compared susceptibilities among the three trimesters of gestation. Manganese (Mn) is a naturally occurring and abundant trace element in the environment. Although the effects of Mn on animals are well documented, knowledge of the effects of Mn exposure on pregnant women and fetuses remains limited. A longitudinal study was conducted by collecting blood samples during all three trimesters, and Mn exposure was completely characterized during gestation. The aims of this study were to examine the effects of maternal Mn exposure on neonatal birth outcomes and to explore the critical stage of these effects.In total, 38, 76 and 76 samples were obtained from singleton pregnant women in their first, second and third trimesters, respectively. The cohort of pregnant women was selected at a medical center in northern Taiwan. Erythrocyte samples were collected during the first, second and third trimesters of gestation. Erythrocyte Mn concentrations were measured by inductively coupled plasma mass spectrometry. Neonatal birth outcomes were evaluated immediately after delivery. A multivariate regression model was used to determine the associations between maternal Mn levels in erythrocytes in each trimester and neonatal birth outcomes.The geometric mean concentrations of Mn were 2.93. μg/dL, 3.96. μg/dL and 4.41. μg/dL in the first, second and third trimesters, respectively. After adjusting for potential confounders, a consistently negative association was found between maternal Mn levels throughout the three trimesters and birth outcomes. Log-transformed Mn levels in maternal erythrocytes in the second trimester were significantly associated with neonatal birth weight, head and chest circumferences, respectively (. β=-556.98. g, p=0.038; β=-1.87. cm, p=0.045; β=-2.74. cm, p=0.024). Despite the limited sample size in the first trimester, negative effects of maternal Mn levels on birth weight (. β=-1108.95. g, p",
keywords = "Birth outcomes, Birth weight, Chest circumference, Critical stage of pregnancy exposure, Erythrocyte manganese, Head circumference",
author = "Tsai, {Ming Song} and Liao, {Kai Wei} and Chang, {Chia Huang} and Chien, {Ling Chu} and Mao, {I. Fang} and Tsai, {Yen An} and Chen, {Mei Lien}",
year = "2015",
month = "2",
day = "1",
doi = "10.1016/j.envres.2014.12.010",
language = "English",
volume = "137",
pages = "215--221",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - The critical fetal stage for maternal manganese exposure

AU - Tsai, Ming Song

AU - Liao, Kai Wei

AU - Chang, Chia Huang

AU - Chien, Ling Chu

AU - Mao, I. Fang

AU - Tsai, Yen An

AU - Chen, Mei Lien

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Prenatal exposure and the health effects of that exposure have been intensively studied for a variety of environmental pollutants and trace elements. However, few studies have compared susceptibilities among the three trimesters of gestation. Manganese (Mn) is a naturally occurring and abundant trace element in the environment. Although the effects of Mn on animals are well documented, knowledge of the effects of Mn exposure on pregnant women and fetuses remains limited. A longitudinal study was conducted by collecting blood samples during all three trimesters, and Mn exposure was completely characterized during gestation. The aims of this study were to examine the effects of maternal Mn exposure on neonatal birth outcomes and to explore the critical stage of these effects.In total, 38, 76 and 76 samples were obtained from singleton pregnant women in their first, second and third trimesters, respectively. The cohort of pregnant women was selected at a medical center in northern Taiwan. Erythrocyte samples were collected during the first, second and third trimesters of gestation. Erythrocyte Mn concentrations were measured by inductively coupled plasma mass spectrometry. Neonatal birth outcomes were evaluated immediately after delivery. A multivariate regression model was used to determine the associations between maternal Mn levels in erythrocytes in each trimester and neonatal birth outcomes.The geometric mean concentrations of Mn were 2.93. μg/dL, 3.96. μg/dL and 4.41. μg/dL in the first, second and third trimesters, respectively. After adjusting for potential confounders, a consistently negative association was found between maternal Mn levels throughout the three trimesters and birth outcomes. Log-transformed Mn levels in maternal erythrocytes in the second trimester were significantly associated with neonatal birth weight, head and chest circumferences, respectively (. β=-556.98. g, p=0.038; β=-1.87. cm, p=0.045; β=-2.74. cm, p=0.024). Despite the limited sample size in the first trimester, negative effects of maternal Mn levels on birth weight (. β=-1108.95. g, p

AB - Prenatal exposure and the health effects of that exposure have been intensively studied for a variety of environmental pollutants and trace elements. However, few studies have compared susceptibilities among the three trimesters of gestation. Manganese (Mn) is a naturally occurring and abundant trace element in the environment. Although the effects of Mn on animals are well documented, knowledge of the effects of Mn exposure on pregnant women and fetuses remains limited. A longitudinal study was conducted by collecting blood samples during all three trimesters, and Mn exposure was completely characterized during gestation. The aims of this study were to examine the effects of maternal Mn exposure on neonatal birth outcomes and to explore the critical stage of these effects.In total, 38, 76 and 76 samples were obtained from singleton pregnant women in their first, second and third trimesters, respectively. The cohort of pregnant women was selected at a medical center in northern Taiwan. Erythrocyte samples were collected during the first, second and third trimesters of gestation. Erythrocyte Mn concentrations were measured by inductively coupled plasma mass spectrometry. Neonatal birth outcomes were evaluated immediately after delivery. A multivariate regression model was used to determine the associations between maternal Mn levels in erythrocytes in each trimester and neonatal birth outcomes.The geometric mean concentrations of Mn were 2.93. μg/dL, 3.96. μg/dL and 4.41. μg/dL in the first, second and third trimesters, respectively. After adjusting for potential confounders, a consistently negative association was found between maternal Mn levels throughout the three trimesters and birth outcomes. Log-transformed Mn levels in maternal erythrocytes in the second trimester were significantly associated with neonatal birth weight, head and chest circumferences, respectively (. β=-556.98. g, p=0.038; β=-1.87. cm, p=0.045; β=-2.74. cm, p=0.024). Despite the limited sample size in the first trimester, negative effects of maternal Mn levels on birth weight (. β=-1108.95. g, p

KW - Birth outcomes

KW - Birth weight

KW - Chest circumference

KW - Critical stage of pregnancy exposure

KW - Erythrocyte manganese

KW - Head circumference

UR - http://www.scopus.com/inward/record.url?scp=84920894228&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920894228&partnerID=8YFLogxK

U2 - 10.1016/j.envres.2014.12.010

DO - 10.1016/j.envres.2014.12.010

M3 - Article

C2 - 25575372

AN - SCOPUS:84920894228

VL - 137

SP - 215

EP - 221

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

ER -