The correlation between fatty liver disease and chronic kidney disease

Po Chun Chen, Wei Yu Kao, Yuan Lung Cheng, Yuan Jen Wang, Ming Chih Hou, Jaw Ching Wu, Chien Wei Su

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background/purpose: The impact of non-alcoholic fatty liver disease (NAFLD) on the prevalence of chronic kidney disease (CKD) is not fully elucidated. We aimed to assess the correlation between NAFLD and CKD in a large population study. Methods: We included consecutive subjects who had received health check-up service at Taipei Veterans General Hospital from 2002 to 2009. NAFLD was diagnosed with abdominal ultrasound, and advanced liver fibrosis was determined with NAFLD fibrosis score (NAFLD-FS). CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m 2 . Results: Among the 29,797 subjects enrolled in this study, NAFLD and CKD were diagnosed in 44.5% and 20.2% of the population, respectively. Subjects with NAFLD had a higher proportion of CKD compared to those without NAFLD (24.1% vs. 17.1%, p < 0.001). However, NAFLD was not related to CKD with an odds ratio (OR) of 1.015 (95% confidence interval [CI] 0.954–1.081, p = 0.630) after multivariate analyses. Nevertheless, further analyses revealed that among patients with NAFLD, those with advanced fibrosis were more likely to have CKD after adjusting for confounding factors (OR 2.284, 95% CI 1.513–3.448, p < 0.001). Conclusion: NAFLD per se was not a risk factor for CKD, but NAFLD patients with advanced fibrosis faced a higher possibility of CKD. Hence, patients with NAFLD and advanced fibrosis should be screened for CKD and prompted to receive treatment if the diagnosis was made.

Original languageEnglish
Pages (from-to)42-50
Number of pages9
JournalJournal of the Formosan Medical Association
Volume119
Issue number1P1
DOIs
Publication statusAccepted/In press - Jan 1 2019

Keywords

  • Kidney diseases
  • Liver fibrosis
  • Non-alcoholic fatty liver disease

ASJC Scopus subject areas

  • Medicine(all)

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