Abstract
The main medicinal property of garlic is mostly attributed to its organosulfur compounds, of which the oil-soluble diallyl disulfide (DADS) is the principal component of distilled garlic oil. Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important cellular regulator in response to oxidative stress. This study assessed the possible protective effect of DADS on doxorubicin (Dox)-induced nephrotoxicity and its potential regulation of the Nrf2 pathway. Treatment with DADS (200 μM) induced heme oxygenase (HO)-1 and NADPH quinone oxidoreductase 1 (NQO-1) expression in a human proximal tubular cell line. The induction of HO-1 expression was suppressed in Nrf2-silenced cells. In an animal study, pretreatment with DADS relieved Dox-induced albuminuria, increased catalase activity, and reduced the urinary 8-hydroxy-2’-deoxyguanosine level. In addition, DADS ameliorated the severity of glomerulosclerosis and suppressed expressions of fibrotic and inflammatory gene expressions. Our data indicate that DADS, a major component of garlic, showed protective effects of preventing the progression of Dox-induced nephropathy through enhancing Nrf2-mediated antioxidant activity. DADS, a normal constituent of the human diet, merits investigation as a potential antioxidant daily food supplement against free radical-mediated chronic diseases.
Original language | English |
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Pages (from-to) | 1040-1046 |
Number of pages | 7 |
Journal | Food Science and Technology |
Volume | 39 |
Issue number | 4 |
DOIs | |
Publication status | Published - Oct 1 2019 |
Keywords
- 8-Hydroxy-2’-deoxyguanosine
- Catalase
- Heme oxygenase 1
- Nuclear factor erythroid 2-related factor 2
- Organosulfur compounds
ASJC Scopus subject areas
- Biotechnology
- Food Science
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The compound, diallyl disulfide, enriched in garlic, prevents the progression of doxorubicin-induced nephropathy
Lin, S. (Contributor), Chagnaadorj, A. (Contributor), Bayarsengee, U. (Contributor), Leung, T. (Contributor) & Cheng, C. (Contributor), SciELO journals, 2019
DOI: 10.6084/m9.figshare.11313437.v1, https://scielo.figshare.com/articles/The_compound_diallyl_disulfide_enriched_in_garlic_prevents_the_progression_of_doxorubicin-induced_nephropathy/11313437/1
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The compound, diallyl disulfide, enriched in garlic, prevents the progression of doxorubicin-induced nephropathy
Lin, S. (Contributor), Chagnaadorj, A. (Contributor), Bayarsengee, U. (Contributor), Leung, T. (Contributor) & Cheng, C. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.8195240.v1, https://scielo.figshare.com/articles/The_compound_diallyl_disulfide_enriched_in_garlic_prevents_the_progression_of_doxorubicin-induced_nephropathy/8195240/1
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