The clinicopathological analysis of 303 cases with malignant lymphoma classified according to the World Health Organization classification system in a single institute of Taiwan

Wei Liang Chen, Wen Chiuan Tsai, Tsu Yi Chao, Lai Fa Sheu, Jung Mao Chou, Woei Yau Kao, Yeu Chin Chen, Ching Liang Ho

Research output: Contribution to journalArticle

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Abstract

Several reports have shown a different distribution of malignant lymphoma (ML) in Asian and Western populations. The purpose of our survey was to elucidate whether there are substantial differences in the frequencies of subtypes of ML between different geographical areas. All entities diagnosed as ML between June 1995 and December 2007 were selected according to the 2008 World Health Organization (WHO) classification and searched for clinical outcomes. The cases were retrieved and reviewed by a panel of clinical haematologists and haematopathologists. A total of 303 patients with ML were identified for retrospective analysis. Of the 303 patients with ML, 278 patients (91.7%) had non-Hodgkin's lymphoma (NHL), and 25 (9.2%) had Hodgkin's lymphoma. Of the 278 patients with NHL, 223 (73.6%) had lymphoma of B-cell lineage, and 55 (18.1%) had lymphoma of T-cell lineage. One hundred and thirty-seven patients were diagnosed with diffuse large B-cell lymphoma, which was the most common B-cell lineage subtype and accounted for 45.2% of patients with NHL. Peripheral T-cell lymphomas were the most frequent subset of the T-cell neoplasms, comprising 10.6% of ML. Extranodal involvement was found in 125 (44.9%) of the 278 patients with NHL, and the lymph node was the site of primary involvement in 153 patients (55.1%). Fifty-nine (47.2%) of the 125 patients with extranodal presentation had gastrointestinal tract involvement. Outcome was worse in patients with extranodal NHL than in those with nodal NHL through the entire follow-up period; the difference in survival rates was significant. Our findings clarify the applicability and prognostic relevance of the WHO classification system and provide further information about the incidence of various lymphoma subtypes in Taiwan. Primary extranodal NHL was associated with a worse prognosis and distinct characteristics compared with nodal NHL. The outcome of different types of extranodal NHL should be investigated further.

Original languageEnglish
Pages (from-to)553-562
Number of pages10
JournalAnnals of Hematology
Volume89
Issue number6
DOIs
Publication statusPublished - Jun 2010
Externally publishedYes

Fingerprint

Taiwan
Non-Hodgkin's Lymphoma
Lymphoma
Cell Lineage
Peripheral T-Cell Lymphoma
Lymphoma, Large B-Cell, Diffuse
T-Lymphocyte Subsets
Hodgkin Disease
Gastrointestinal Tract
B-Lymphocytes
Survival Rate
Lymph Nodes
Incidence

Keywords

  • Extranodal non-Hodgkin's lymphoma
  • Malignant lymphoma
  • Survival
  • World Health Organization classification

ASJC Scopus subject areas

  • Hematology

Cite this

The clinicopathological analysis of 303 cases with malignant lymphoma classified according to the World Health Organization classification system in a single institute of Taiwan. / Chen, Wei Liang; Tsai, Wen Chiuan; Chao, Tsu Yi; Sheu, Lai Fa; Chou, Jung Mao; Kao, Woei Yau; Chen, Yeu Chin; Ho, Ching Liang.

In: Annals of Hematology, Vol. 89, No. 6, 06.2010, p. 553-562.

Research output: Contribution to journalArticle

Chen, Wei Liang ; Tsai, Wen Chiuan ; Chao, Tsu Yi ; Sheu, Lai Fa ; Chou, Jung Mao ; Kao, Woei Yau ; Chen, Yeu Chin ; Ho, Ching Liang. / The clinicopathological analysis of 303 cases with malignant lymphoma classified according to the World Health Organization classification system in a single institute of Taiwan. In: Annals of Hematology. 2010 ; Vol. 89, No. 6. pp. 553-562.
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