The clinical outcomes and predictive factors for in-hospital mortality in non-neutropenic patients with candidemia

Tsai Yu Wang, Chia Yen Hung, Shian Sen Shie, Pai Chien Chou, Chih Hsi Kuo, Fu Tsai Chung, Yu Lun Lo, Shu Min Lin

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4 Citations (Scopus)

Abstract

Recent epidemiologic studies have showed that candidemia is an important nosocomial infection in hospitalized patients. The majority of candidemia patients were non-neutropenic rather than neutropenic status. The aimof this studywas todetermine the clinical outcomeof non-neutropenic patients with candidemia and to measure the contributing factors formortality. A total of 163 non-neutropenic patients with candidemia during January 2010 to December 2013 were retrospectively enrolled. The patients' risk factors for mortality, clinical outcomes, treatment regimens, and Candida species were analyzed. The overall mortality was 54.6%. Candida albicans was themost frequent Candida species (n=83; 50.9% of patients). Under multivariate analyses, hemodialysis (OR, 4.554; 95% CI, 1.464-14.164) and the use of amphotericin B deoxycholate (OR, 8.709; 95%CI, 1.587-47.805) were independent factors associated withmortality. In contrast, abdominal surgery (OR, 0.360; 95%CI, 0.158-0.816)was associated with a better outcome. The overallmortality is still high in non-neutropenic patients with candidemia.Hemodialysis and use ofamphotericinBdeoxycholate were independent factors associated with mortality, whereas prior abdominal surgery was associated with a better outcome.

Original languageEnglish
Article numbere3834
JournalMedicine (United States)
Volume95
Issue number23
DOIs
Publication statusPublished - Jan 1 2016
Externally publishedYes

Keywords

  • Candidemia
  • Fungus
  • Mortality
  • Predictive factor

ASJC Scopus subject areas

  • Medicine(all)

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