The choroid plexus is an important circadian clock component

J. Myung, C. Schmal, S. Hong, Y. Tsukizawa, P. Rose, Y. Zhang, M.J. Holtzman, E. De Schutter, H. Herzel, G. Bordyugov, T. Takumi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Mammalian circadian clocks have a hierarchical organization, governed by the suprachiasmatic nucleus (SCN) in the hypothalamus. The brain itself contains multiple loci that maintain autonomous circadian rhythmicity, but the contribution of the non-SCN clocks to this hierarchy remains unclear. We examine circadian oscillations of clock gene expression in various brain loci and discovered that in mouse, robust, higher amplitude, relatively faster oscillations occur in the choroid plexus (CP) compared to the SCN. Our computational analysis and modeling show that the CP achieves these properties by synchronization of "twist" circadian oscillators via gap-junctional connections. Using an in vitro tissue coculture model and in vivo targeted deletion of the Bmal1 gene to silence the CP circadian clock, we demonstrate that the CP clock adjusts the SCN clock likely via circulation of cerebrospinal fluid, thus finely tuning behavioral circadian rhythms.

Original languageEnglish
Article number1062
Pages (from-to)1062
JournalNature Communications
Volume9
Issue number1
DOIs
Publication statusPublished - Dec 1 2018

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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  • Cite this

    Myung, J., Schmal, C., Hong, S., Tsukizawa, Y., Rose, P., Zhang, Y., Holtzman, M. J., De Schutter, E., Herzel, H., Bordyugov, G., & Takumi, T. (2018). The choroid plexus is an important circadian clock component. Nature Communications, 9(1), 1062. [1062]. https://doi.org/10.1038/s41467-018-03507-2