The characteristics of 206 long-term survivors with peritoneal metastases from colorectal cancer treated with curative intent surgery: A multi-center cohort from psogi

Yasuyuki Kamada, Koya Hida, Yutaka Yonemura, Paul H. Sugarbaker, Shadin Ghabra, Soichiro Ishihara, Hiroshi Nagata, Koji Murono, Takanori Goi, Kanji Katayama, Mitsuhiro Morikawa, Beate Rau, Pompiliu Piso, Miklos Acs, Federico Coccolini, Emel Canbay, Mao Chih Hsieh, Aditi Bhatt, Pierre Emmanuel Bonnot, Olivier Glehen

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We conducted this study to review the patient characteristics associated with long-term survival in patients with peritoneal metastases from colorectal cancer who underwent cytoreductive surgery (CRS). Methods: We retrospectively investigated patients with peritoneal metastases from CRC treated with curative intent surgery with or without hyperthermic intraperi-toneal chemotherapy at 13 institutions worldwide between January 1985 and April 2015 and survived longer than five years after the first CRS for peritoneal metastases. Clinical and oncological features and therapeutic parameters were described and analyzed. Results: Two hundred six long-term survivors were available for study. The median peritoneal cancer index (PCI) of this cohort was 4 (interquartile range (IQR), 2–7), and the median score of the small bowel regions of the PCI (SB-PCI) was 0 (IQR, 0–2). Complete cytoreduction (CC-0) was achieved in 180 (87.4%) patients. Recurrence was observed in 122 (59.2%) patients at a median of 1.8 (IQR, 1.2–2.6) years. Conclusions: While most long-term survivors showed low PCI/SB-PCI and CCR-0, some had characteristics considered associated with poor prognosis. Curative intent treatments may be considered in well-informed and fit patients showing negative factors affecting survival outcome.

Original languageEnglish
Article number2964
JournalCancers
Volume13
Issue number12
DOIs
Publication statusPublished - Jun 2 2021

Keywords

  • Colorectal cancer
  • Cytoreductive surgery
  • HIPEC
  • Long-term survivors
  • Peritoneal metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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