The cerebellar development in chinese children-a study by voxel-based volume measurement of reconstructed 3D MRI scan

Kuan Hsun Wu, Chia Yuan Chen, Ein-Yiao Shen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Cerebellar disorder was frequently reported to have relation with structural brain volume alteration and/or morphology change. In dealing with such clinical situations, we need a convenient and noninvasive imaging tool to provide clinicians with a means of tracing developmental changes in the cerebellum. Herein, we present a new daily practice method for cerebellum imaging that uses a work station and a software program to process reconstructed 3D neuroimages after MRI scanning. In a 3-y period, 3D neuroimages reconstructed from MRI scans of 50 children aged 0.2-12.7 y were taken. The resulting images were then statistically analyzed against a growth curve. We observed a remarkable increase in the size of the cerebellum in the first 2 y of life. Furthermore, the unmyelinated cerebellum grew mainly between birth and 2 y of age in the postnatal stage. In contrast, the postnatal development of the brain mainly depended on the growth of myelinated cerebellum from birth through adolescence. This study presents basic data from a study of ethnic Chinese children's cerebellums using reconstructed 3D brain images. Based on the technique we introduce here, clinicians can evaluate the growth of the brain.

Original languageEnglish
Pages (from-to)80-83
Number of pages4
JournalPediatric Research
Volume69
Issue number1
DOIs
Publication statusPublished - Jan 2011

Fingerprint

Cerebellum
Magnetic Resonance Imaging
Brain
Growth
Parturition
Cerebellar Diseases
Software

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

The cerebellar development in chinese children-a study by voxel-based volume measurement of reconstructed 3D MRI scan. / Wu, Kuan Hsun; Chen, Chia Yuan; Shen, Ein-Yiao.

In: Pediatric Research, Vol. 69, No. 1, 01.2011, p. 80-83.

Research output: Contribution to journalArticle

@article{40ebd427710a44f3bd4b479560db5b04,
title = "The cerebellar development in chinese children-a study by voxel-based volume measurement of reconstructed 3D MRI scan",
abstract = "Cerebellar disorder was frequently reported to have relation with structural brain volume alteration and/or morphology change. In dealing with such clinical situations, we need a convenient and noninvasive imaging tool to provide clinicians with a means of tracing developmental changes in the cerebellum. Herein, we present a new daily practice method for cerebellum imaging that uses a work station and a software program to process reconstructed 3D neuroimages after MRI scanning. In a 3-y period, 3D neuroimages reconstructed from MRI scans of 50 children aged 0.2-12.7 y were taken. The resulting images were then statistically analyzed against a growth curve. We observed a remarkable increase in the size of the cerebellum in the first 2 y of life. Furthermore, the unmyelinated cerebellum grew mainly between birth and 2 y of age in the postnatal stage. In contrast, the postnatal development of the brain mainly depended on the growth of myelinated cerebellum from birth through adolescence. This study presents basic data from a study of ethnic Chinese children's cerebellums using reconstructed 3D brain images. Based on the technique we introduce here, clinicians can evaluate the growth of the brain.",
author = "Wu, {Kuan Hsun} and Chen, {Chia Yuan} and Ein-Yiao Shen",
year = "2011",
month = "1",
doi = "10.1203/PDR.0b013e3181ff2f6c",
language = "English",
volume = "69",
pages = "80--83",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - The cerebellar development in chinese children-a study by voxel-based volume measurement of reconstructed 3D MRI scan

AU - Wu, Kuan Hsun

AU - Chen, Chia Yuan

AU - Shen, Ein-Yiao

PY - 2011/1

Y1 - 2011/1

N2 - Cerebellar disorder was frequently reported to have relation with structural brain volume alteration and/or morphology change. In dealing with such clinical situations, we need a convenient and noninvasive imaging tool to provide clinicians with a means of tracing developmental changes in the cerebellum. Herein, we present a new daily practice method for cerebellum imaging that uses a work station and a software program to process reconstructed 3D neuroimages after MRI scanning. In a 3-y period, 3D neuroimages reconstructed from MRI scans of 50 children aged 0.2-12.7 y were taken. The resulting images were then statistically analyzed against a growth curve. We observed a remarkable increase in the size of the cerebellum in the first 2 y of life. Furthermore, the unmyelinated cerebellum grew mainly between birth and 2 y of age in the postnatal stage. In contrast, the postnatal development of the brain mainly depended on the growth of myelinated cerebellum from birth through adolescence. This study presents basic data from a study of ethnic Chinese children's cerebellums using reconstructed 3D brain images. Based on the technique we introduce here, clinicians can evaluate the growth of the brain.

AB - Cerebellar disorder was frequently reported to have relation with structural brain volume alteration and/or morphology change. In dealing with such clinical situations, we need a convenient and noninvasive imaging tool to provide clinicians with a means of tracing developmental changes in the cerebellum. Herein, we present a new daily practice method for cerebellum imaging that uses a work station and a software program to process reconstructed 3D neuroimages after MRI scanning. In a 3-y period, 3D neuroimages reconstructed from MRI scans of 50 children aged 0.2-12.7 y were taken. The resulting images were then statistically analyzed against a growth curve. We observed a remarkable increase in the size of the cerebellum in the first 2 y of life. Furthermore, the unmyelinated cerebellum grew mainly between birth and 2 y of age in the postnatal stage. In contrast, the postnatal development of the brain mainly depended on the growth of myelinated cerebellum from birth through adolescence. This study presents basic data from a study of ethnic Chinese children's cerebellums using reconstructed 3D brain images. Based on the technique we introduce here, clinicians can evaluate the growth of the brain.

UR - http://www.scopus.com/inward/record.url?scp=78650837442&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650837442&partnerID=8YFLogxK

U2 - 10.1203/PDR.0b013e3181ff2f6c

DO - 10.1203/PDR.0b013e3181ff2f6c

M3 - Article

C2 - 20924316

AN - SCOPUS:78650837442

VL - 69

SP - 80

EP - 83

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 1

ER -