The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting

Chin Chen Chu, Chung-Hsi Hsing, Ja Ping Shieh, Chih Chiang Chien, Chiu Ming Ho, Jhi Joung Wang

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Glucocorticoids, used primarily as anti-allergic and anti-inflammatory drugs, are also effective, alone or combined with other antiemetics, for preventing nausea and vomiting. Dexamethasone, one of the glucocorticoids, has been suggested as a first-line drug for preventing low-level emetogenic chemotherapy- and radiotherapy-induced nausea and vomiting, and in patients with only one or two risks for postoperative nausea and vomiting (PONV). Dexamethasone combined with 5-HT3 or tachykinin NK1 antagonists is also suggested for higher-level emetogenic chemotherapy and radiotherapy and for patients at high risk for PONV. Glucocorticoids may act via the following mechanisms: (1) anti-inflammatory effect; (2) direct central action at the solitary tract nucleus, (3) interaction with the neurotransmitter serotonin, and receptor proteins tachykinin NK1 and NK2, alpha-adrenaline, etc.; (4) maintaining the normal physiological functions of organs and systems; (5) regulation of the hypothalamic-pituitary-adrenal axis; and (6) reducing pain and the concomitant use of opioids, which in turn reduces opioid-related nausea and vomiting.

Original languageEnglish
Pages (from-to)48-54
Number of pages7
JournalEuropean Journal of Pharmacology
Volume722
Issue number1
DOIs
Publication statusPublished - Feb 5 2014

Fingerprint

Antiemetics
Nausea
Dexamethasone
Glucocorticoids
Vomiting
Tachykinins
Postoperative Nausea and Vomiting
Opioid Analgesics
Anti-Inflammatory Agents
Radiotherapy
Drug Therapy
Anti-Allergic Agents
Neurotransmitter Receptor
Solitary Nucleus
Serotonin Receptors
Pharmaceutical Preparations
Epinephrine
Pain
Proteins

Keywords

  • CINV
  • Dexamethasone
  • Emesis
  • Glucocorticoids
  • PONV
  • RINV

ASJC Scopus subject areas

  • Pharmacology

Cite this

The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting. / Chu, Chin Chen; Hsing, Chung-Hsi; Shieh, Ja Ping; Chien, Chih Chiang; Ho, Chiu Ming; Wang, Jhi Joung.

In: European Journal of Pharmacology, Vol. 722, No. 1, 05.02.2014, p. 48-54.

Research output: Contribution to journalArticle

Chu, Chin Chen ; Hsing, Chung-Hsi ; Shieh, Ja Ping ; Chien, Chih Chiang ; Ho, Chiu Ming ; Wang, Jhi Joung. / The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting. In: European Journal of Pharmacology. 2014 ; Vol. 722, No. 1. pp. 48-54.
@article{d3a01fafd3a54c50b8dc6f8ad9cdd1c3,
title = "The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting",
abstract = "Glucocorticoids, used primarily as anti-allergic and anti-inflammatory drugs, are also effective, alone or combined with other antiemetics, for preventing nausea and vomiting. Dexamethasone, one of the glucocorticoids, has been suggested as a first-line drug for preventing low-level emetogenic chemotherapy- and radiotherapy-induced nausea and vomiting, and in patients with only one or two risks for postoperative nausea and vomiting (PONV). Dexamethasone combined with 5-HT3 or tachykinin NK1 antagonists is also suggested for higher-level emetogenic chemotherapy and radiotherapy and for patients at high risk for PONV. Glucocorticoids may act via the following mechanisms: (1) anti-inflammatory effect; (2) direct central action at the solitary tract nucleus, (3) interaction with the neurotransmitter serotonin, and receptor proteins tachykinin NK1 and NK2, alpha-adrenaline, etc.; (4) maintaining the normal physiological functions of organs and systems; (5) regulation of the hypothalamic-pituitary-adrenal axis; and (6) reducing pain and the concomitant use of opioids, which in turn reduces opioid-related nausea and vomiting.",
keywords = "CINV, Dexamethasone, Emesis, Glucocorticoids, PONV, RINV",
author = "Chu, {Chin Chen} and Chung-Hsi Hsing and Shieh, {Ja Ping} and Chien, {Chih Chiang} and Ho, {Chiu Ming} and Wang, {Jhi Joung}",
year = "2014",
month = "2",
day = "5",
doi = "10.1016/j.ejphar.2013.10.008",
language = "English",
volume = "722",
pages = "48--54",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting

AU - Chu, Chin Chen

AU - Hsing, Chung-Hsi

AU - Shieh, Ja Ping

AU - Chien, Chih Chiang

AU - Ho, Chiu Ming

AU - Wang, Jhi Joung

PY - 2014/2/5

Y1 - 2014/2/5

N2 - Glucocorticoids, used primarily as anti-allergic and anti-inflammatory drugs, are also effective, alone or combined with other antiemetics, for preventing nausea and vomiting. Dexamethasone, one of the glucocorticoids, has been suggested as a first-line drug for preventing low-level emetogenic chemotherapy- and radiotherapy-induced nausea and vomiting, and in patients with only one or two risks for postoperative nausea and vomiting (PONV). Dexamethasone combined with 5-HT3 or tachykinin NK1 antagonists is also suggested for higher-level emetogenic chemotherapy and radiotherapy and for patients at high risk for PONV. Glucocorticoids may act via the following mechanisms: (1) anti-inflammatory effect; (2) direct central action at the solitary tract nucleus, (3) interaction with the neurotransmitter serotonin, and receptor proteins tachykinin NK1 and NK2, alpha-adrenaline, etc.; (4) maintaining the normal physiological functions of organs and systems; (5) regulation of the hypothalamic-pituitary-adrenal axis; and (6) reducing pain and the concomitant use of opioids, which in turn reduces opioid-related nausea and vomiting.

AB - Glucocorticoids, used primarily as anti-allergic and anti-inflammatory drugs, are also effective, alone or combined with other antiemetics, for preventing nausea and vomiting. Dexamethasone, one of the glucocorticoids, has been suggested as a first-line drug for preventing low-level emetogenic chemotherapy- and radiotherapy-induced nausea and vomiting, and in patients with only one or two risks for postoperative nausea and vomiting (PONV). Dexamethasone combined with 5-HT3 or tachykinin NK1 antagonists is also suggested for higher-level emetogenic chemotherapy and radiotherapy and for patients at high risk for PONV. Glucocorticoids may act via the following mechanisms: (1) anti-inflammatory effect; (2) direct central action at the solitary tract nucleus, (3) interaction with the neurotransmitter serotonin, and receptor proteins tachykinin NK1 and NK2, alpha-adrenaline, etc.; (4) maintaining the normal physiological functions of organs and systems; (5) regulation of the hypothalamic-pituitary-adrenal axis; and (6) reducing pain and the concomitant use of opioids, which in turn reduces opioid-related nausea and vomiting.

KW - CINV

KW - Dexamethasone

KW - Emesis

KW - Glucocorticoids

KW - PONV

KW - RINV

UR - http://www.scopus.com/inward/record.url?scp=84892843818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892843818&partnerID=8YFLogxK

U2 - 10.1016/j.ejphar.2013.10.008

DO - 10.1016/j.ejphar.2013.10.008

M3 - Article

VL - 722

SP - 48

EP - 54

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1

ER -