The Cancer Editome Atlas: A resource for exploratory analysis of the adenosine-to-inosine RNA editome in cancer

Chui Hsien Lin, Sean Chun Chang Chen

Research output: Contribution to journalArticle

Abstract

Increasing evidence has suggested a role for adenosine-to-inosine RNA editing in carcinogenesis. However, the clinical utility of RNA editing remains limited because functions of the vast majority of editing events remain largely unexplored. To help the cancer research community investigate functional consequences of individual editing events, we have developed a user-friendly bioinformatic resource, The Cancer Editome Atlas (TCEA; http://tcea.tmu.edu.tw). TCEA characterizes >192 million editing events at >4.6 million editing sites from approximately 11,000 samples across 33 cancer types in The Cancer Genome Atlas. Clinical information, miRNA expression, and alteration in miRNA targeting modulated through RNA editing are also integrated into TCEA. TCEA supports several modules to search, analyze, and visualize the cancer editome, providing a solid basis for investigating the oncogenic mechanisms of RNA editing and expediting the identification of therapeutic targets in cancer. Significance: This user-friendly bioinformatic resource reduces the barrier to analyzing the huge and complex cancer RNA editome that cancer researchers face and facilitates the identification of novel therapeutic targets in cancer.

Original languageEnglish
Pages (from-to)3001-3006
Number of pages6
JournalCancer Research
Volume79
Issue number11
DOIs
Publication statusPublished - Jun 1 2019

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Inosine
Atlases
Adenosine
RNA
RNA Editing
Neoplasms
Computational Biology
MicroRNAs
Carcinogenesis
Research Personnel
Genome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The Cancer Editome Atlas : A resource for exploratory analysis of the adenosine-to-inosine RNA editome in cancer. / Lin, Chui Hsien; Chen, Sean Chun Chang.

In: Cancer Research, Vol. 79, No. 11, 01.06.2019, p. 3001-3006.

Research output: Contribution to journalArticle

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