33 Citations (Scopus)

Abstract

This study summarizes our most recent findings on the mechanisms underlying the cadmium-induced death of mesangial cells, which leads to nephrotoxicity. Multiple pathways participate in cadmium-induced nephrotoxicity. In the ROS-GSK-3β autophagy pathway, cadmium induces ROS most likely from the mitochondria, and the ROS consequently activate GSK-3β leading to autophagic cell death. In the calcium-ERK autophagy and apoptosis pathway, cadmium stimulates calcium release from the endoplasmic reticulum, which activates ERK leading to predominantly autophagic cell death and a minor level of apoptotic cell death. In the calcium-mitochondria-caspase apoptosis pathway, cadmium-induced elevation of calcium depolarizes the mitochondrial membrane potential and then activates caspase signaling leading to apoptosis. A proposed model for cadmium-induced autophagy and apoptosis leading to nephrotoxicity is summarized in Figure 1.

Original languageEnglish
Pages (from-to)571-572
Number of pages2
JournalAutophagy
Volume5
Issue number4
DOIs
Publication statusPublished - May 16 2009

Fingerprint

Mesangial Cells
Cadmium
Autophagy
Apoptosis
Calcium
Glycogen Synthase Kinase 3
Caspases
Mitochondria
Mitochondrial Membrane Potential
Endoplasmic Reticulum
Cell Death

Keywords

  • Apoptosis
  • Autophagy
  • Cadmium
  • Calcium
  • GSK-3β

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

The cadmium-induced death of mesangial cells results in nephrotoxicity. / Yang, Liang Yo; Wu, Kuan Hsun; Chiu, Wen Ta; Wang, Sheng Hao; Shih, Chwen Ming.

In: Autophagy, Vol. 5, No. 4, 16.05.2009, p. 571-572.

Research output: Contribution to journalArticle

Yang, Liang Yo ; Wu, Kuan Hsun ; Chiu, Wen Ta ; Wang, Sheng Hao ; Shih, Chwen Ming. / The cadmium-induced death of mesangial cells results in nephrotoxicity. In: Autophagy. 2009 ; Vol. 5, No. 4. pp. 571-572.
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AU - Shih, Chwen Ming

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