The biphasic changes of insulin secretion in schizophrenic patients treated with olanzapine

Mong-Liang Lu, Chun-Hsin Chen, Hui Ching Liu, Po Yu Chen, Shu Han Yu, Chih Chiang Chiu

Research output: Contribution to journalArticle

Abstract

The object of this study was to evaluate the time course of effects of olanzapine treatment on pancreatic β-cell function in second generation antipsychotics-naïve patients with schizophrenia. Thirty-six schizophrenic subjects received olanzapine therapy for 8 weeks and 31 of them completed the trial. The metabolic parameters were quantitatively assessed at weeks 0, 2, 4 and 8 by the intravenous glucose tolerance test. After 56-day olanzapine treatment, subjects had significant increases in body weight, insulin resistance, β-cell function and the levels of triglyceride and low-density lipoprotein. Insulin secretion significantly decreased at week 2, returned to baseline at week 4 and significantly increased at week 8. Female subjects were more vulnerable to the olanzapine-induced metabolic adversity than male subjects. Of the total sample, 16.1%, 22.6% and 3.2% of them met the criteria for significant weight gain, metabolic syndrome and diabetes mellitus, respectively. This study indicates that olanzapine-treated schizophrenic patients displayed biphasic changes in insulin secretion to a hyperglycemic challenge. The results of this study support that olanzapine might directly influence pancreatic β-cell function.
Original languageEnglish
Pages (from-to)1186
JournalJournal of Psychopharmacology
Volume27
Issue number12
DOIs
Publication statusPublished - Aug 2008

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olanzapine
Biphasic Insulins
Insulin
Glucose Tolerance Test
Antipsychotic Agents
Weight Gain
Insulin Resistance
Schizophrenia
Diabetes Mellitus
Therapeutics
Body Weight

Keywords

  • Retraction of Publication

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The biphasic changes of insulin secretion in schizophrenic patients treated with olanzapine. / Lu, Mong-Liang; Chen, Chun-Hsin; Liu, Hui Ching; Chen, Po Yu; Yu, Shu Han; Chiu, Chih Chiang.

In: Journal of Psychopharmacology, Vol. 27, No. 12, 08.2008, p. 1186.

Research output: Contribution to journalArticle

Lu, Mong-Liang ; Chen, Chun-Hsin ; Liu, Hui Ching ; Chen, Po Yu ; Yu, Shu Han ; Chiu, Chih Chiang. / The biphasic changes of insulin secretion in schizophrenic patients treated with olanzapine. In: Journal of Psychopharmacology. 2008 ; Vol. 27, No. 12. pp. 1186.
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AB - The object of this study was to evaluate the time course of effects of olanzapine treatment on pancreatic β-cell function in second generation antipsychotics-naïve patients with schizophrenia. Thirty-six schizophrenic subjects received olanzapine therapy for 8 weeks and 31 of them completed the trial. The metabolic parameters were quantitatively assessed at weeks 0, 2, 4 and 8 by the intravenous glucose tolerance test. After 56-day olanzapine treatment, subjects had significant increases in body weight, insulin resistance, β-cell function and the levels of triglyceride and low-density lipoprotein. Insulin secretion significantly decreased at week 2, returned to baseline at week 4 and significantly increased at week 8. Female subjects were more vulnerable to the olanzapine-induced metabolic adversity than male subjects. Of the total sample, 16.1%, 22.6% and 3.2% of them met the criteria for significant weight gain, metabolic syndrome and diabetes mellitus, respectively. This study indicates that olanzapine-treated schizophrenic patients displayed biphasic changes in insulin secretion to a hyperglycemic challenge. The results of this study support that olanzapine might directly influence pancreatic β-cell function.

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