The Bioimaging Applications of Mesoporous Silica Nanoparticles: Enzymes

F.W. Pratiwi, C.W. Kuo, S.-H. Wu, Y.-P. Chen, C.Y. Mou, P. Chen, Tamanoi F. (Editor)

Research output: Book/ReportBook

1 Citation (Scopus)

Abstract

The unique features of Mesoporous Silica Nanoparticles (MSNs) provide a suitable platform to carry fluorescence dyes for various bioimaging applications. Several strategies have been developed to conjugate a variety of dyes either in the pores or on the surfaces of MSNs to form the fluorescence MSNs (FMSNs). In this chapter, we will discuss recent research progress and future development of FMSNs for living system imaging. We will first describe different strategies for the fabrications of FMSNs. Then, we will discuss the recent developments of cellular and intracellular imaging including self-probe for the interactions of FMSNs with the cells, receptor and organelle labeling, sensing and tracking of biological system, and monitoring the drug delivery and release processes. Moreover, we will include the applications of FMSNs as contrast agents for in vivo imaging. Finally, we will conclude and highlight the challenges and opportunities for MSNs in medical applications. © 2018 Elsevier Inc.
Original languageEnglish
PublisherInternational Academic Press
Number of pages31
Volume43
ISBN (Print)18746047 (ISSN); 9780128151129 (ISBN)
DOIs
Publication statusPublished - 2018

Fingerprint

Silicon Dioxide
Fluorescence
Nanoparticles
Enzymes
Coloring Agents
Imaging techniques
Medical applications
Biological systems
Drug delivery
Imaging systems
Labeling
Contrast Media
Fabrication
Monitoring

Keywords

  • Bioimaging
  • Mesoporous silica nanoparticles
  • Nanomedicine
  • Surface modification
  • Targeted delivery
  • Theranostics

Cite this

Pratiwi, F. W., Kuo, C. W., Wu, S-H., Chen, Y-P., Mou, C. Y., Chen, P., & F., T. (Ed.) (2018). The Bioimaging Applications of Mesoporous Silica Nanoparticles: Enzymes. International Academic Press. https://doi.org/10.1016/bs.enz.2018.07.006

The Bioimaging Applications of Mesoporous Silica Nanoparticles : Enzymes. / Pratiwi, F.W.; Kuo, C.W.; Wu, S.-H.; Chen, Y.-P.; Mou, C.Y.; Chen, P.; F., Tamanoi (Editor).

International Academic Press, 2018. 31 p.

Research output: Book/ReportBook

Pratiwi, FW, Kuo, CW, Wu, S-H, Chen, Y-P, Mou, CY, Chen, P & F., T (ed.) 2018, The Bioimaging Applications of Mesoporous Silica Nanoparticles: Enzymes. vol. 43, International Academic Press. https://doi.org/10.1016/bs.enz.2018.07.006
Pratiwi, F.W. ; Kuo, C.W. ; Wu, S.-H. ; Chen, Y.-P. ; Mou, C.Y. ; Chen, P. ; F., Tamanoi (Editor). / The Bioimaging Applications of Mesoporous Silica Nanoparticles : Enzymes. International Academic Press, 2018. 31 p.
@book{47ed55ebfe81437ba6a9532c1e18dd0e,
title = "The Bioimaging Applications of Mesoporous Silica Nanoparticles: Enzymes",
abstract = "The unique features of Mesoporous Silica Nanoparticles (MSNs) provide a suitable platform to carry fluorescence dyes for various bioimaging applications. Several strategies have been developed to conjugate a variety of dyes either in the pores or on the surfaces of MSNs to form the fluorescence MSNs (FMSNs). In this chapter, we will discuss recent research progress and future development of FMSNs for living system imaging. We will first describe different strategies for the fabrications of FMSNs. Then, we will discuss the recent developments of cellular and intracellular imaging including self-probe for the interactions of FMSNs with the cells, receptor and organelle labeling, sensing and tracking of biological system, and monitoring the drug delivery and release processes. Moreover, we will include the applications of FMSNs as contrast agents for in vivo imaging. Finally, we will conclude and highlight the challenges and opportunities for MSNs in medical applications. {\circledC} 2018 Elsevier Inc.",
keywords = "Bioimaging, Mesoporous silica nanoparticles, Nanomedicine, Surface modification, Targeted delivery, Theranostics",
author = "F.W. Pratiwi and C.W. Kuo and S.-H. Wu and Y.-P. Chen and C.Y. Mou and P. Chen",
editor = "Tamanoi F.",
note = "Export Date: 25 October 2018 Correspondence Address: Chen, P.; Research Center for Applied Sciences, Academia SinicaTaiwan; email: peilin@gate.sinica.edu.tw References: Hell, S.W., Wichmann, J., Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy (1994) Opt. Lett., 19 (11), pp. 780-782; Eggeling, C., Direct observation of the nanoscale dynamics of membrane lipids in a living cell (2009) Nature, 457 (7233), pp. 1159-1162; Schermelleh, L., Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy (2008) Science, 320 (5881), pp. 1332-1336; Betzig, E., Imaging intracellular fluorescent proteins at nanometer resolution (2006) Science, 313 (5793), p. 1642; Manley, S., High-density mapping of single-molecule trajectories with photoactivated localization microscopy (2008) Nat. Methods, 5 (2), pp. 155-157; Huang, B., Three-dimensional super-resolution imaging by stochastic optical reconstruction microscopy (2008) Science, 319 (5864), pp. 810-813; Rust, M.J., Bates, M., Zhuang, X., Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM) (2006) Nat. Methods, 3 (10), pp. 793-796; Mura, S., Nicolas, J., Couvreur, P., Stimuli-responsive nanocarriers for drug delivery (2013) Nat. Mater., 12 (11), pp. 991-1003; Gim{\'e}nez, C., Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells (2015) Langmuir, 31 (12), pp. 3753-3762; Lai, C.-Y., A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules (2003) J. Am. Chem. Soc., 125 (15), pp. 4451-4459; Cai, Q., Dilute solution routes to various controllable morphologies of MCM-41 silica with a basic medium (2001) Chem. Mater., 13 (2), pp. 258-263; Fowler, C.E., Nanoscale materials with mesostructured interiors (2001) Adv. Mater., 13 (9), pp. 649-652; Nooney, R.I., Synthesis of nanoscale mesoporous silica spheres with controlled particle size (2002) Chem. Mater., 14 (11), pp. 4721-4728; Kresge, C.T., Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism (1992) Nature, 359, p. 710; Frank, H., Silica-based mesoporous organic–inorganic hybrid materials (2006) Angew. Chem. Int. Ed., 45 (20), pp. 3216-3251; Lin, Y.-S., Well-ordered mesoporous silica nanoparticles as cell markers (2005) Chem. Mater., 17 (18), pp. 4570-4573; Shigeyuki, M., Yuya, O., Hiroaki, I., Incorporation of dyes into silica–surfactant mesostructured nanoparticles as a nanoscale host material for organic molecules (2006) Chem. Lett., 35 (8), pp. 880-881; Igor, S., Kievsky, Y.Y., Kaszpurenko, J.M., Self-assembly of ultrabright fluorescent silica particles (2007) Small, 3 (3), pp. 419-423; Kim, T.-W., Chung, P.-W., Lin, V.S.Y., Facile synthesis of monodisperse spherical MCM-48 mesoporous silica nanoparticles with controlled particle size (2010) Chem. Mater., 22 (17), pp. 5093-5104; Liu, A., Fluorescent hybrid with electron acceptor methylene viologen units inside the pore walls of mesoporous MCM-48 silica (2010) Langmuir, 26 (5), pp. 3555-3561; Suk Ho, H., Hyunjin, K., Yongdoo, C., Indocyanine green-loaded hollow mesoporous silica nanoparticles as an activatable theranostic agent (2017) Nanotechnology, 28 (18), p. 185102; Lin, Y.-S., Synthesis of hollow silica nanospheres with a microemulsion as the template (2009) Chem. Commun., 24, pp. 3542-3544; Wu, X.-J., Xu, D., Formation of yolk/SiO2 shell structures using surfactant mixtures as template (2009) J. Am. Chem. Soc., 131 (8), pp. 2774-2775; Pan, Y., Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer (2016) Nanoscale, 8 (2), pp. 878-888; Zhao, L., Yolk–shell upconversion nanocomposites for LRET sensing of cysteine/homocysteine (2014) ACS Appl. Mater. Interfaces, 6 (14), pp. 11190-11197; Teng, Z., Mesoporous silica hollow spheres with ordered radial mesochannels by a spontaneous self-transformation approach (2013) Chem. Mater., 25 (1), pp. 98-105; Tierui, Z., Formation of hollow silica colloids through a spontaneous dissolution–regrowth process (2008) Angew. Chem. Int. Ed., 47 (31), pp. 5806-5811; Lei, J., Wang, L., Zhang, J., Superbright multifluorescent core − shell mesoporous nanospheres as trackable transport carrier for drug (2011) ACS Nano, 5 (5), pp. 3447-3455; Kim, J., Magnetic fluorescent delivery vehicle using uniform mesoporous silica spheres embedded with monodisperse magnetic and semiconductor nanocrystals (2006) J. Am. Chem. Soc., 128 (3), pp. 688-689; Ciccione, J., Unambiguous and controlled one-pot synthesis of multifunctional silica nanoparticles (2016) Chem. Mater., 28 (3), pp. 885-889; Heidegger, S., Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery (2016) Nanoscale, 8 (2), pp. 938-948; Ahn, B., Mesoporous silica nanoparticle-based cisplatin prodrug delivery and anticancer effect under reductive cellular environment (2013) J. Mater. Chem. B, 1 (22), pp. 2829-2836; Huang, X., The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo (2011) ACS Nano, 5 (7), pp. 5390-5399; Chia-Hung, L., Near-infrared mesoporous silica nanoparticles for optical imaging: characterization and in vivo biodistribution (2009) Adv. Funct. Mater., 19 (2), pp. 215-222; Sreejith, S., Ma, X., Zhao, Y., Graphene oxide wrapping on squaraine-loaded mesoporous silica nanoparticles for bioimaging (2012) J. Am. Chem. Soc., 134 (42), pp. 17346-17349; Sathe, T.R., Agrawal, A., Nie, S., Mesoporous silica beads embedded with semiconductor quantum dots and iron oxide nanocrystals: dual-function microcarriers for optical encoding and magnetic separation (2006) Anal. Chem., 78 (16), pp. 5627-5632; Juying, L., Carbon dot-incorporated PMO nanoparticles as versatile platforms for the design of ratiometric sensors, multichannel traceable drug delivery vehicles, and efficient photocatalysts (2015) Adv. Opt. Mater., 3 (1), pp. 57-63; Pandey, S., Synthesis of mesoporous silica oxide/C-dot complex (meso-SiO2/C-dots) using pyrolysed rice husk and its application in bioimaging (2014) RSC Adv., 4 (3), pp. 1174-1179; Jianan, L., Controlled synthesis of uniform and monodisperse upconversion core/mesoporous silica Shell nanocomposites for bimodal imaging (2012) Chem. Eur. J., 18 (8), pp. 2335-2341; Slowing, I., Trewyn, B.G., Lin, V.S.Y., Effect of surface functionalization of MCM-41-type mesoporous silica nanoparticles on the endocytosis by human cancer cells (2006) J. Am. Chem. Soc., 128 (46), pp. 14792-14793; Chung, T.-H., The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3T3-L1 cells and human mesenchymal stem cells (2007) Biomaterials, 28 (19), pp. 2959-2966; Fang, L., Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles (2009) Small, 5 (12), pp. 1408-1413; Jiang, W., Nanoparticle-mediated cellular response is size-dependent (2008) Nat. Nanotechnol., 3, p. 145; Chithrani, B.D., Ghazani, A.A., Chan, W.C.W., Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells (2006) Nano Lett., 6 (4), pp. 662-668; Aoyama, M., Intracellular trafficking of particles inside endosomal vesicles is regulated by particle size (2017) J. Control. Release, 260, pp. 183-193; Chen, Y.-P., Surface charge effect in intracellular localization of mesoporous silica nanoparticles as probed by fluorescent ratiometric pH imaging (2012) RSC Adv., 2 (3), pp. 968-973; Liong, M., Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery (2008) ACS Nano, 2 (5), pp. 889-896; Wu, C.-H., Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side chain (2013) ACS Appl. Mater. Interfaces, 5 (23), pp. 12244-12248; Jian, Y., Membrane fusion mediated intracellular delivery of lipid bilayer coated mesoporous silica nanoparticles (2017) Adv. Healthc. Mater., 6 (20), p. 1700759; Chou, C.-C., Molecular elucidation of biological response to mesoporous silica nanoparticles in vitro and in vivo (2017) ACS Appl. Mater. Interfaces, 9 (27), pp. 22235-22251; Tsai, C.-P., Monoclonal antibody-functionalized mesoporous silica nanoparticles (MSN) for selective targeting breast cancer cells (2009) J. Mater. Chem., 19 (32), pp. 5737-5743; Liu, Z., YSA-conjugated mesoporous silica nanoparticles effectively target EphA2-overexpressing breast cancer cells (2018) Cancer Chemother. Pharmacol., 81 (4), pp. 687-695; Bouchoucha, M., Antibody-conjugated mesoporous silica nanoparticles for brain microvessel endothelial cell targeting (2017) J. Mater. Chem. B, 5 (37), pp. 7721-7735; Palantavida, S., Ultrabright fluorescent mesoporous silica nanoparticles for prescreening of cervical cancer (2013) Nanomed. Nanotechnol. Biol. Med., 9 (8), pp. 1255-1262; Hurley, M.T., Synthesis, characterization, and application of antibody functionalized fluorescent silica nanoparticles (2013) Adv. Funct. Mater., 23 (26), pp. 3335-3343; Qi, G., Vancomycin-modified mesoporous silica nanoparticles for selective recognition and killing of pathogenic gram-positive bacteria over macrophage-like cells (2013) ACS Appl. Mater. Interfaces, 5 (21), pp. 10874-10881; Liu, S., Reaction-based phosphorescent nanosensor for ratiometric and time-resolved luminescence imaging of fluoride in live cells (2015) Chem. Commun., 51 (64), pp. 12839-12842; Zhang, K.Y., Core-shell structured phosphorescent nanoparticles for detection of exogenous and endogenous hypochlorite in live cells via ratiometric imaging and photoluminescence lifetime imaging microscopy (2015) Chem. Sci., 6 (1), pp. 301-307; Dong, F., An engineered thermo-sensitive nanohybrid particle for accurate temperature sensing at the single-cell level and biologically controlled thermal therapy (2016) J. Mater. Chem. 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year = "2018",
doi = "10.1016/bs.enz.2018.07.006",
language = "English",
isbn = "18746047 (ISSN); 9780128151129 (ISBN)",
volume = "43",
publisher = "International Academic Press",
address = "United States",

}

TY - BOOK

T1 - The Bioimaging Applications of Mesoporous Silica Nanoparticles

T2 - Enzymes

AU - Pratiwi, F.W.

AU - Kuo, C.W.

AU - Wu, S.-H.

AU - Chen, Y.-P.

AU - Mou, C.Y.

AU - Chen, P.

A2 - F., Tamanoi

N1 - Export Date: 25 October 2018 Correspondence Address: Chen, P.; Research Center for Applied Sciences, Academia SinicaTaiwan; email: peilin@gate.sinica.edu.tw References: Hell, S.W., Wichmann, J., Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy (1994) Opt. Lett., 19 (11), pp. 780-782; Eggeling, C., Direct observation of the nanoscale dynamics of membrane lipids in a living cell (2009) Nature, 457 (7233), pp. 1159-1162; Schermelleh, L., Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy (2008) Science, 320 (5881), pp. 1332-1336; Betzig, E., Imaging intracellular fluorescent proteins at nanometer resolution (2006) Science, 313 (5793), p. 1642; Manley, S., High-density mapping of single-molecule trajectories with photoactivated localization microscopy (2008) Nat. Methods, 5 (2), pp. 155-157; Huang, B., Three-dimensional super-resolution imaging by stochastic optical reconstruction microscopy (2008) Science, 319 (5864), pp. 810-813; Rust, M.J., Bates, M., Zhuang, X., Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM) (2006) Nat. Methods, 3 (10), pp. 793-796; Mura, S., Nicolas, J., Couvreur, P., Stimuli-responsive nanocarriers for drug delivery (2013) Nat. Mater., 12 (11), pp. 991-1003; Giménez, C., Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells (2015) Langmuir, 31 (12), pp. 3753-3762; Lai, C.-Y., A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules (2003) J. Am. Chem. Soc., 125 (15), pp. 4451-4459; Cai, Q., Dilute solution routes to various controllable morphologies of MCM-41 silica with a basic medium (2001) Chem. Mater., 13 (2), pp. 258-263; Fowler, C.E., Nanoscale materials with mesostructured interiors (2001) Adv. Mater., 13 (9), pp. 649-652; Nooney, R.I., Synthesis of nanoscale mesoporous silica spheres with controlled particle size (2002) Chem. Mater., 14 (11), pp. 4721-4728; Kresge, C.T., Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism (1992) Nature, 359, p. 710; Frank, H., Silica-based mesoporous organic–inorganic hybrid materials (2006) Angew. Chem. Int. Ed., 45 (20), pp. 3216-3251; Lin, Y.-S., Well-ordered mesoporous silica nanoparticles as cell markers (2005) Chem. Mater., 17 (18), pp. 4570-4573; Shigeyuki, M., Yuya, O., Hiroaki, I., Incorporation of dyes into silica–surfactant mesostructured nanoparticles as a nanoscale host material for organic molecules (2006) Chem. Lett., 35 (8), pp. 880-881; Igor, S., Kievsky, Y.Y., Kaszpurenko, J.M., Self-assembly of ultrabright fluorescent silica particles (2007) Small, 3 (3), pp. 419-423; Kim, T.-W., Chung, P.-W., Lin, V.S.Y., Facile synthesis of monodisperse spherical MCM-48 mesoporous silica nanoparticles with controlled particle size (2010) Chem. Mater., 22 (17), pp. 5093-5104; Liu, A., Fluorescent hybrid with electron acceptor methylene viologen units inside the pore walls of mesoporous MCM-48 silica (2010) Langmuir, 26 (5), pp. 3555-3561; Suk Ho, H., Hyunjin, K., Yongdoo, C., Indocyanine green-loaded hollow mesoporous silica nanoparticles as an activatable theranostic agent (2017) Nanotechnology, 28 (18), p. 185102; Lin, Y.-S., Synthesis of hollow silica nanospheres with a microemulsion as the template (2009) Chem. Commun., 24, pp. 3542-3544; Wu, X.-J., Xu, D., Formation of yolk/SiO2 shell structures using surfactant mixtures as template (2009) J. Am. Chem. Soc., 131 (8), pp. 2774-2775; Pan, Y., Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer (2016) Nanoscale, 8 (2), pp. 878-888; Zhao, L., Yolk–shell upconversion nanocomposites for LRET sensing of cysteine/homocysteine (2014) ACS Appl. Mater. Interfaces, 6 (14), pp. 11190-11197; Teng, Z., Mesoporous silica hollow spheres with ordered radial mesochannels by a spontaneous self-transformation approach (2013) Chem. Mater., 25 (1), pp. 98-105; Tierui, Z., Formation of hollow silica colloids through a spontaneous dissolution–regrowth process (2008) Angew. Chem. Int. Ed., 47 (31), pp. 5806-5811; Lei, J., Wang, L., Zhang, J., Superbright multifluorescent core − shell mesoporous nanospheres as trackable transport carrier for drug (2011) ACS Nano, 5 (5), pp. 3447-3455; Kim, J., Magnetic fluorescent delivery vehicle using uniform mesoporous silica spheres embedded with monodisperse magnetic and semiconductor nanocrystals (2006) J. Am. Chem. Soc., 128 (3), pp. 688-689; Ciccione, J., Unambiguous and controlled one-pot synthesis of multifunctional silica nanoparticles (2016) Chem. Mater., 28 (3), pp. 885-889; Heidegger, S., Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery (2016) Nanoscale, 8 (2), pp. 938-948; Ahn, B., Mesoporous silica nanoparticle-based cisplatin prodrug delivery and anticancer effect under reductive cellular environment (2013) J. Mater. Chem. B, 1 (22), pp. 2829-2836; Huang, X., The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo (2011) ACS Nano, 5 (7), pp. 5390-5399; Chia-Hung, L., Near-infrared mesoporous silica nanoparticles for optical imaging: characterization and in vivo biodistribution (2009) Adv. Funct. Mater., 19 (2), pp. 215-222; Sreejith, S., Ma, X., Zhao, Y., Graphene oxide wrapping on squaraine-loaded mesoporous silica nanoparticles for bioimaging (2012) J. Am. Chem. Soc., 134 (42), pp. 17346-17349; Sathe, T.R., Agrawal, A., Nie, S., Mesoporous silica beads embedded with semiconductor quantum dots and iron oxide nanocrystals: dual-function microcarriers for optical encoding and magnetic separation (2006) Anal. Chem., 78 (16), pp. 5627-5632; Juying, L., Carbon dot-incorporated PMO nanoparticles as versatile platforms for the design of ratiometric sensors, multichannel traceable drug delivery vehicles, and efficient photocatalysts (2015) Adv. Opt. Mater., 3 (1), pp. 57-63; Pandey, S., Synthesis of mesoporous silica oxide/C-dot complex (meso-SiO2/C-dots) using pyrolysed rice husk and its application in bioimaging (2014) RSC Adv., 4 (3), pp. 1174-1179; Jianan, L., Controlled synthesis of uniform and monodisperse upconversion core/mesoporous silica Shell nanocomposites for bimodal imaging (2012) Chem. Eur. J., 18 (8), pp. 2335-2341; Slowing, I., Trewyn, B.G., Lin, V.S.Y., Effect of surface functionalization of MCM-41-type mesoporous silica nanoparticles on the endocytosis by human cancer cells (2006) J. Am. Chem. Soc., 128 (46), pp. 14792-14793; Chung, T.-H., The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3T3-L1 cells and human mesenchymal stem cells (2007) Biomaterials, 28 (19), pp. 2959-2966; Fang, L., Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles (2009) Small, 5 (12), pp. 1408-1413; Jiang, W., Nanoparticle-mediated cellular response is size-dependent (2008) Nat. Nanotechnol., 3, p. 145; Chithrani, B.D., Ghazani, A.A., Chan, W.C.W., Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells (2006) Nano Lett., 6 (4), pp. 662-668; Aoyama, M., Intracellular trafficking of particles inside endosomal vesicles is regulated by particle size (2017) J. Control. Release, 260, pp. 183-193; Chen, Y.-P., Surface charge effect in intracellular localization of mesoporous silica nanoparticles as probed by fluorescent ratiometric pH imaging (2012) RSC Adv., 2 (3), pp. 968-973; Liong, M., Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery (2008) ACS Nano, 2 (5), pp. 889-896; Wu, C.-H., Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side chain (2013) ACS Appl. Mater. Interfaces, 5 (23), pp. 12244-12248; Jian, Y., Membrane fusion mediated intracellular delivery of lipid bilayer coated mesoporous silica nanoparticles (2017) Adv. Healthc. Mater., 6 (20), p. 1700759; Chou, C.-C., Molecular elucidation of biological response to mesoporous silica nanoparticles in vitro and in vivo (2017) ACS Appl. Mater. Interfaces, 9 (27), pp. 22235-22251; Tsai, C.-P., Monoclonal antibody-functionalized mesoporous silica nanoparticles (MSN) for selective targeting breast cancer cells (2009) J. Mater. Chem., 19 (32), pp. 5737-5743; Liu, Z., YSA-conjugated mesoporous silica nanoparticles effectively target EphA2-overexpressing breast cancer cells (2018) Cancer Chemother. Pharmacol., 81 (4), pp. 687-695; Bouchoucha, M., Antibody-conjugated mesoporous silica nanoparticles for brain microvessel endothelial cell targeting (2017) J. Mater. Chem. B, 5 (37), pp. 7721-7735; Palantavida, S., Ultrabright fluorescent mesoporous silica nanoparticles for prescreening of cervical cancer (2013) Nanomed. Nanotechnol. Biol. Med., 9 (8), pp. 1255-1262; Hurley, M.T., Synthesis, characterization, and application of antibody functionalized fluorescent silica nanoparticles (2013) Adv. Funct. Mater., 23 (26), pp. 3335-3343; Qi, G., Vancomycin-modified mesoporous silica nanoparticles for selective recognition and killing of pathogenic gram-positive bacteria over macrophage-like cells (2013) ACS Appl. Mater. Interfaces, 5 (21), pp. 10874-10881; Liu, S., Reaction-based phosphorescent nanosensor for ratiometric and time-resolved luminescence imaging of fluoride in live cells (2015) Chem. Commun., 51 (64), pp. 12839-12842; Zhang, K.Y., Core-shell structured phosphorescent nanoparticles for detection of exogenous and endogenous hypochlorite in live cells via ratiometric imaging and photoluminescence lifetime imaging microscopy (2015) Chem. Sci., 6 (1), pp. 301-307; Dong, F., An engineered thermo-sensitive nanohybrid particle for accurate temperature sensing at the single-cell level and biologically controlled thermal therapy (2016) J. Mater. Chem. 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PY - 2018

Y1 - 2018

N2 - The unique features of Mesoporous Silica Nanoparticles (MSNs) provide a suitable platform to carry fluorescence dyes for various bioimaging applications. Several strategies have been developed to conjugate a variety of dyes either in the pores or on the surfaces of MSNs to form the fluorescence MSNs (FMSNs). In this chapter, we will discuss recent research progress and future development of FMSNs for living system imaging. We will first describe different strategies for the fabrications of FMSNs. Then, we will discuss the recent developments of cellular and intracellular imaging including self-probe for the interactions of FMSNs with the cells, receptor and organelle labeling, sensing and tracking of biological system, and monitoring the drug delivery and release processes. Moreover, we will include the applications of FMSNs as contrast agents for in vivo imaging. Finally, we will conclude and highlight the challenges and opportunities for MSNs in medical applications. © 2018 Elsevier Inc.

AB - The unique features of Mesoporous Silica Nanoparticles (MSNs) provide a suitable platform to carry fluorescence dyes for various bioimaging applications. Several strategies have been developed to conjugate a variety of dyes either in the pores or on the surfaces of MSNs to form the fluorescence MSNs (FMSNs). In this chapter, we will discuss recent research progress and future development of FMSNs for living system imaging. We will first describe different strategies for the fabrications of FMSNs. Then, we will discuss the recent developments of cellular and intracellular imaging including self-probe for the interactions of FMSNs with the cells, receptor and organelle labeling, sensing and tracking of biological system, and monitoring the drug delivery and release processes. Moreover, we will include the applications of FMSNs as contrast agents for in vivo imaging. Finally, we will conclude and highlight the challenges and opportunities for MSNs in medical applications. © 2018 Elsevier Inc.

KW - Bioimaging

KW - Mesoporous silica nanoparticles

KW - Nanomedicine

KW - Surface modification

KW - Targeted delivery

KW - Theranostics

U2 - 10.1016/bs.enz.2018.07.006

DO - 10.1016/bs.enz.2018.07.006

M3 - Book

SN - 18746047 (ISSN); 9780128151129 (ISBN)

VL - 43

BT - The Bioimaging Applications of Mesoporous Silica Nanoparticles

PB - International Academic Press

ER -