The bidirectional association among female hormone-related cancers: Breast, ovary, and uterine corpus

Min Chi Chen, Kuan Der Lee, Chang Hsien Lu, Ting Yao Wang, Shih Hao Huang, Chao Yu Chen

Research output: Contribution to journalArticle

Abstract

Breast, ovarian, and uterine corpus cancers are common female cancers and categorized as hormone-related diseases. Previous studies reported a unidirectional relationship for each cancer, but few studied the reciprocal association in the same cohort. A population-based study was carried out in Taiwan to test the hypothesis that there are pairwise bidirectional associations among these cancers. Using the same cohort of 110,112 cases with primary female cancers including uterine corpus cancer (11,146 cases), ovarian cancer (12,139 cases), or breast cancer (86,827 cases) from the Taiwan Cancer Registry from 1979 to 2008, the pairwise risks of second cancer among uterine corpus, ovary, and breast cancer cases were evaluated by standardized incidence ratios (SIRs) and the corresponding 95% confidence intervals (CIs) to quantify the excess of second malignancies. A reciprocal relationship was found for these three female cancers, particularly most prominent between uterine and ovarian cancers, followed by breast and uterine cancers as well as breast and ovarian cancers. The overall risk of second cancers was highest within the first 5 years after the diagnosis of primary cancer. The bidirectional relationships suggest common risk factors among these three female cancers. This is the largest cohort study to focus on the bidirectional associations among hormone-related cancers in Asian women, and these results could aid in the development of early prevention strategies and follow-up surveillance programs.

Original languageEnglish
JournalCancer Medicine
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Ovarian Neoplasms
Hormones
Breast Neoplasms
Uterine Neoplasms
Neoplasms
Second Primary Neoplasms
Taiwan
Registries
Breast
Cohort Studies
Confidence Intervals
Incidence
Population

Keywords

  • Breast cancer
  • Ovarian cancer
  • Second cancer
  • Taiwan Cancer Registry
  • Uterine cancer

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

The bidirectional association among female hormone-related cancers : Breast, ovary, and uterine corpus. / Chen, Min Chi; Lee, Kuan Der; Lu, Chang Hsien; Wang, Ting Yao; Huang, Shih Hao; Chen, Chao Yu.

In: Cancer Medicine, 01.01.2018.

Research output: Contribution to journalArticle

Chen, Min Chi ; Lee, Kuan Der ; Lu, Chang Hsien ; Wang, Ting Yao ; Huang, Shih Hao ; Chen, Chao Yu. / The bidirectional association among female hormone-related cancers : Breast, ovary, and uterine corpus. In: Cancer Medicine. 2018.
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