Abstract

The aim of this study was to develop a new diagnostic and therapeutic approach for the treatment of osteoporosis. Previously, we demonstrated that intraosseous transplantation of platelet-rich plasma (PRP) treated-osteoblast-like cells into ovariectomized senescence-accelerated mice (OVX-SAMP8) prevented the development of osteoporosis. In continuation, we aimed to explore the complex etiology of osteoporosis using this platform. An inverse relationship between bone marrow adipogenesis and osteogenesis has been suggested in the development of osteoporosis but the underlying mechanisms remain poorly described. To address these issues, we used PRP to inhibit adipocyte differentiation by promoting osteoblastic differentiation in adipocytes. In addition, a positive correlation between an increase in bone marrow adipocytes and bone loss was established. We assessed this relationship using an osteoporotic animal disease model which consisted of young (for prevention) and old (for treatment) OVX-SAMP8 mice. This animal model demonstrated that PRP treatment mainly exerted its action via promoting bone regeneration but also appeared to suppress adipogenesis within the marrow. The findings and methodology of this study could potentially be applied in the prevention and treatment of osteoporosis.

Original languageEnglish
Pages (from-to)6773-6780
Number of pages8
JournalBiomaterials
Volume32
Issue number28
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Adipogenesis
Bone Regeneration
Platelet-Rich Plasma
Platelets
Osteogenesis
Osteoporosis
Bone
Plasmas
Adipocytes
Bone Marrow
Animals
Osteoblasts
Animal Disease Models
Animal Models
Transplantation
Bone and Bones

Keywords

  • Adipocyte
  • Osteoporosis
  • Ovariectomized senescence-accelerated mice (OVX-SAMP8)
  • Platelet-rich plasma (PRP)
  • Prevention and treatment

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

Cite this

The balance between adipogenesis and osteogenesis in bone regeneration by platelet-rich plasma for age-related osteoporosis. / Liu, Hen Yu; Wu, Alexander T H; Tsai, Ching Yu; Chou, Kuei Ru; Zeng, Rong; Wang, Ming Fu; Chang, Wen Chang; Hwang, Shiaw Min; Su, Ching-Hua; Deng, Win Ping.

In: Biomaterials, Vol. 32, No. 28, 10.2011, p. 6773-6780.

Research output: Contribution to journalArticle

Liu, Hen Yu ; Wu, Alexander T H ; Tsai, Ching Yu ; Chou, Kuei Ru ; Zeng, Rong ; Wang, Ming Fu ; Chang, Wen Chang ; Hwang, Shiaw Min ; Su, Ching-Hua ; Deng, Win Ping. / The balance between adipogenesis and osteogenesis in bone regeneration by platelet-rich plasma for age-related osteoporosis. In: Biomaterials. 2011 ; Vol. 32, No. 28. pp. 6773-6780.
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