The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults

Chien Yu Lin, Li Li Wen, Lian Yu Lin, Ting Wen Wen, Guang Wen Lien, Sandy H.J. Hsu, Kuo Liong Chien, Chien Chang Liao, Fung Chang Sung, Pau Chung Chen, Ta Chen Su

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


Perfluorinated chemicals (PFCs) have been widely used in a variety of products worldwide for years. However, the effect of PFCs on thyroid function has not yet been clearly defined. We recruited 567 subjects (aged 12-30 years) in a population-based cohort of adolescents and young adults with abnormal urinalysis in the childhood to determine the relationship between serum level of PFCs and the levels of serum free thyroxine (T4) and thyroid stimulating hormone (TSH). The geometric means and geometric standard deviation concentrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA) were 2.67 (2.96). ng/ml, 7.78 (2.42). ng/ml, 1.01 (3.48). ng/ml and 5.81 (2.92). ng/ml, respectively. Differences in the levels of free T4 and TSH across different categories of PFOA, PFOS and PFUA were insignificant. After controlling for confounding factors, multiple linear regression analyses revealed mean serum level of free T4 increased significantly across categories (<60th, 60-89 and >90th percentiles) of PFNA (P for trend =0.012 in the full model). The association between PFNA and free T4 was more significant in male subjects in age group 20-30, active smokers and in those with higher body mass index in stratified analysis. Serum concentrations of PFNA were associated with serum free T4 levels in adolescents and young adults.

Original languageEnglish
Pages (from-to)637-644
Number of pages8
JournalJournal of Hazardous Materials
Publication statusPublished - Jan 5 2013


  • Humans
  • PFC
  • PFNA
  • Thyroid
  • Thyroxine

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution
  • Health, Toxicology and Mutagenesis


Dive into the research topics of 'The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults'. Together they form a unique fingerprint.

Cite this