The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults

Chien Yu Lin, Li Li Wen, Lian Yu Lin, Ting Wen Wen, Guang Wen Lien, Sandy H J Hsu, Kuo Liong Chien, Chien Chang Liao, Fung Chang Sung, Pau Chung Chen, Ta Chen Su

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Perfluorinated chemicals (PFCs) have been widely used in a variety of products worldwide for years. However, the effect of PFCs on thyroid function has not yet been clearly defined. We recruited 567 subjects (aged 12-30 years) in a population-based cohort of adolescents and young adults with abnormal urinalysis in the childhood to determine the relationship between serum level of PFCs and the levels of serum free thyroxine (T4) and thyroid stimulating hormone (TSH). The geometric means and geometric standard deviation concentrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA) were 2.67 (2.96). ng/ml, 7.78 (2.42). ng/ml, 1.01 (3.48). ng/ml and 5.81 (2.92). ng/ml, respectively. Differences in the levels of free T4 and TSH across different categories of PFOA, PFOS and PFUA were insignificant. After controlling for confounding factors, multiple linear regression analyses revealed mean serum level of free T4 increased significantly across categories (90th percentiles) of PFNA (P for trend =0.012 in the full model). The association between PFNA and free T4 was more significant in male subjects in age group 20-30, active smokers and in those with higher body mass index in stratified analysis. Serum concentrations of PFNA were associated with serum free T4 levels in adolescents and young adults.

Original languageEnglish
Pages (from-to)637-644
Number of pages8
JournalJournal of Hazardous Materials
Volume244-245
DOIs
Publication statusPublished - Jan 5 2013

Fingerprint

perfluorooctanoic acid
serum
Young Adult
Thyroid Gland
Thyroxine
Acids
acid
Thyrotropin
Serum
sulfonate
Linear regression
Urinalysis
hormone
Linear Models
Body Mass Index
Age Groups
Regression Analysis
perfluorononanoic acid
chemical
young

Keywords

  • Humans
  • PFC
  • PFNA
  • Thyroid
  • Thyroxine

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Pollution
  • Waste Management and Disposal
  • Environmental Chemistry
  • Environmental Engineering

Cite this

The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults. / Lin, Chien Yu; Wen, Li Li; Lin, Lian Yu; Wen, Ting Wen; Lien, Guang Wen; Hsu, Sandy H J; Chien, Kuo Liong; Liao, Chien Chang; Sung, Fung Chang; Chen, Pau Chung; Su, Ta Chen.

In: Journal of Hazardous Materials, Vol. 244-245, 05.01.2013, p. 637-644.

Research output: Contribution to journalArticle

Lin, CY, Wen, LL, Lin, LY, Wen, TW, Lien, GW, Hsu, SHJ, Chien, KL, Liao, CC, Sung, FC, Chen, PC & Su, TC 2013, 'The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults', Journal of Hazardous Materials, vol. 244-245, pp. 637-644. https://doi.org/10.1016/j.jhazmat.2012.10.049
Lin, Chien Yu ; Wen, Li Li ; Lin, Lian Yu ; Wen, Ting Wen ; Lien, Guang Wen ; Hsu, Sandy H J ; Chien, Kuo Liong ; Liao, Chien Chang ; Sung, Fung Chang ; Chen, Pau Chung ; Su, Ta Chen. / The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults. In: Journal of Hazardous Materials. 2013 ; Vol. 244-245. pp. 637-644.
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