The association of clinical findings and exposure profiles with melamine associated nephrolithiasis

I. J. Wang, Y. N. Wu, W. C. Wu, G. Leonardi, Y. J. Sung, Tien-Jen Lin, C. L. Wang, C. F. Kuo, K. Y. Wu, W. C. Cheng, C. C. Chan, P. C. Chen, Shoei Loong Lin

Research output: Contribution to journalArticle

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Abstract

Background: Little is known about the exposure profiles of melamine in children. We evaluated the association of clinical findings, exposure patterns and biomarkers with nephrolithiasis in children with potential exposure to melamine. Methods: A case-control study was conducted in children aged 0-16 years with potential exposure to contaminated dairy products. Cases were defined as nephrolithiasis detected by renal ultrasonography. On the basis of different brands of contaminated dairy products consumed, subjects were classified into high exposure, low exposure and control groups with estimated melamine exposure levels of higher than 2.5 ppm, 0.05-2.5 ppm and lower than detection limits <0.05 ppm. We measured urine melamine for those with nephrolithiasis and age-matched and gender-matched controls within the subset of the study population. Results: The duration of consumption of contaminated products was longer in children with nephrolithiasis in the high exposure group than in controls (median (IQR) 12.0 (3.3-24.0) vs 6.0 (4.0-7.0) months; p = 0.048). High melamine exposure levels were significantly associated with nephrolithiasis (OR 61.04 (95% CI 12.73 to 292.84)). The risk was found to increase with estimate melamine exposure levels (p for trend <0.001). Two among 10 affected subjects with nephrolithiasis showed elevated urine melamine levels. In comparison, levels of all 20 controls were lower than the detection limit. Conclusions: The risk of melamine-associated nephrolithiasis was related to duration of consumption of contaminated products and estimated melamine exposure levels. Though urine melamine was not a sensitive test, it might serve as an exposure biomarker in melamine-associated nephrolithiasis.

Original languageEnglish
Pages (from-to)883-887
Number of pages5
JournalArchives of Disease in Childhood
Volume94
Issue number11
DOIs
Publication statusPublished - Nov 1 2009

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Nephrolithiasis
Dairy Products
Urine
Limit of Detection
melamine
Biomarkers
Control Groups
Case-Control Studies
Ultrasonography

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

The association of clinical findings and exposure profiles with melamine associated nephrolithiasis. / Wang, I. J.; Wu, Y. N.; Wu, W. C.; Leonardi, G.; Sung, Y. J.; Lin, Tien-Jen; Wang, C. L.; Kuo, C. F.; Wu, K. Y.; Cheng, W. C.; Chan, C. C.; Chen, P. C.; Lin, Shoei Loong.

In: Archives of Disease in Childhood, Vol. 94, No. 11, 01.11.2009, p. 883-887.

Research output: Contribution to journalArticle

Wang, IJ, Wu, YN, Wu, WC, Leonardi, G, Sung, YJ, Lin, T-J, Wang, CL, Kuo, CF, Wu, KY, Cheng, WC, Chan, CC, Chen, PC & Lin, SL 2009, 'The association of clinical findings and exposure profiles with melamine associated nephrolithiasis', Archives of Disease in Childhood, vol. 94, no. 11, pp. 883-887. https://doi.org/10.1136/adc.2009.163477
Wang, I. J. ; Wu, Y. N. ; Wu, W. C. ; Leonardi, G. ; Sung, Y. J. ; Lin, Tien-Jen ; Wang, C. L. ; Kuo, C. F. ; Wu, K. Y. ; Cheng, W. C. ; Chan, C. C. ; Chen, P. C. ; Lin, Shoei Loong. / The association of clinical findings and exposure profiles with melamine associated nephrolithiasis. In: Archives of Disease in Childhood. 2009 ; Vol. 94, No. 11. pp. 883-887.
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abstract = "Background: Little is known about the exposure profiles of melamine in children. We evaluated the association of clinical findings, exposure patterns and biomarkers with nephrolithiasis in children with potential exposure to melamine. Methods: A case-control study was conducted in children aged 0-16 years with potential exposure to contaminated dairy products. Cases were defined as nephrolithiasis detected by renal ultrasonography. On the basis of different brands of contaminated dairy products consumed, subjects were classified into high exposure, low exposure and control groups with estimated melamine exposure levels of higher than 2.5 ppm, 0.05-2.5 ppm and lower than detection limits <0.05 ppm. We measured urine melamine for those with nephrolithiasis and age-matched and gender-matched controls within the subset of the study population. Results: The duration of consumption of contaminated products was longer in children with nephrolithiasis in the high exposure group than in controls (median (IQR) 12.0 (3.3-24.0) vs 6.0 (4.0-7.0) months; p = 0.048). High melamine exposure levels were significantly associated with nephrolithiasis (OR 61.04 (95{\%} CI 12.73 to 292.84)). The risk was found to increase with estimate melamine exposure levels (p for trend <0.001). Two among 10 affected subjects with nephrolithiasis showed elevated urine melamine levels. In comparison, levels of all 20 controls were lower than the detection limit. Conclusions: The risk of melamine-associated nephrolithiasis was related to duration of consumption of contaminated products and estimated melamine exposure levels. Though urine melamine was not a sensitive test, it might serve as an exposure biomarker in melamine-associated nephrolithiasis.",
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T1 - The association of clinical findings and exposure profiles with melamine associated nephrolithiasis

AU - Wang, I. J.

AU - Wu, Y. N.

AU - Wu, W. C.

AU - Leonardi, G.

AU - Sung, Y. J.

AU - Lin, Tien-Jen

AU - Wang, C. L.

AU - Kuo, C. F.

AU - Wu, K. Y.

AU - Cheng, W. C.

AU - Chan, C. C.

AU - Chen, P. C.

AU - Lin, Shoei Loong

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Background: Little is known about the exposure profiles of melamine in children. We evaluated the association of clinical findings, exposure patterns and biomarkers with nephrolithiasis in children with potential exposure to melamine. Methods: A case-control study was conducted in children aged 0-16 years with potential exposure to contaminated dairy products. Cases were defined as nephrolithiasis detected by renal ultrasonography. On the basis of different brands of contaminated dairy products consumed, subjects were classified into high exposure, low exposure and control groups with estimated melamine exposure levels of higher than 2.5 ppm, 0.05-2.5 ppm and lower than detection limits <0.05 ppm. We measured urine melamine for those with nephrolithiasis and age-matched and gender-matched controls within the subset of the study population. Results: The duration of consumption of contaminated products was longer in children with nephrolithiasis in the high exposure group than in controls (median (IQR) 12.0 (3.3-24.0) vs 6.0 (4.0-7.0) months; p = 0.048). High melamine exposure levels were significantly associated with nephrolithiasis (OR 61.04 (95% CI 12.73 to 292.84)). The risk was found to increase with estimate melamine exposure levels (p for trend <0.001). Two among 10 affected subjects with nephrolithiasis showed elevated urine melamine levels. In comparison, levels of all 20 controls were lower than the detection limit. Conclusions: The risk of melamine-associated nephrolithiasis was related to duration of consumption of contaminated products and estimated melamine exposure levels. Though urine melamine was not a sensitive test, it might serve as an exposure biomarker in melamine-associated nephrolithiasis.

AB - Background: Little is known about the exposure profiles of melamine in children. We evaluated the association of clinical findings, exposure patterns and biomarkers with nephrolithiasis in children with potential exposure to melamine. Methods: A case-control study was conducted in children aged 0-16 years with potential exposure to contaminated dairy products. Cases were defined as nephrolithiasis detected by renal ultrasonography. On the basis of different brands of contaminated dairy products consumed, subjects were classified into high exposure, low exposure and control groups with estimated melamine exposure levels of higher than 2.5 ppm, 0.05-2.5 ppm and lower than detection limits <0.05 ppm. We measured urine melamine for those with nephrolithiasis and age-matched and gender-matched controls within the subset of the study population. Results: The duration of consumption of contaminated products was longer in children with nephrolithiasis in the high exposure group than in controls (median (IQR) 12.0 (3.3-24.0) vs 6.0 (4.0-7.0) months; p = 0.048). High melamine exposure levels were significantly associated with nephrolithiasis (OR 61.04 (95% CI 12.73 to 292.84)). The risk was found to increase with estimate melamine exposure levels (p for trend <0.001). Two among 10 affected subjects with nephrolithiasis showed elevated urine melamine levels. In comparison, levels of all 20 controls were lower than the detection limit. Conclusions: The risk of melamine-associated nephrolithiasis was related to duration of consumption of contaminated products and estimated melamine exposure levels. Though urine melamine was not a sensitive test, it might serve as an exposure biomarker in melamine-associated nephrolithiasis.

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