The association between serum asymmetric dimethylarginine and coronary atherosclerotic plaque in an asymptomatic population

Chun Yao Huang, Jong Shiuan Yeh, Chun Ming Shih, Feng Yen Lin, Yung Ta Kao, Nai Wen Tsao, Wen Tien Hsiao, Jaw Wen Chen, Nen Chung Chang, Kou-Gi Shyu

Research output: Contribution to journalArticlepeer-review

Abstract

Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide synthase and is independently associated with poor cardiovascular outcomes. However, the direct relationship between serum ADMA level and the extent of subclinical coronary atherosclerotic plaque has never been investigated. In total, 130 consecutive asymptomatic Taiwanese subjects (mean age, 55.6±10 years), who received a health screening evaluation, were enrolled. Coronary plaque detected by computed tomography coronary angiography (CTCA) was observed in 85 (65.4%) of 130 individuals. Patients with coronary plaque had a higher ADMA level (1.16±1.15 μmol/L vs. 0.42 ± 0.33 μmol /L, p

Original languageEnglish
Pages (from-to)236-243
Number of pages8
JournalImmunology, Endocrine and Metabolic Agents in Medicinal Chemistry
Volume12
Issue number3
Publication statusPublished - 2012

Keywords

  • Asymmetric dimethylarginine (ADMA)
  • Asymptomatic
  • Atherosclerotic plaque
  • Computed tomography coronary angiography (CTCA)
  • Coronary atherosclerosis
  • Endothelial dysfunction
  • Nitric oxide (NO)

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Pharmacology

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