The association between nonylphenols and sexual hormones levels among pregnant women

A cohort Study in Taiwan

Chia Huang Chang, Ming Song Tsai, Ching Ling Lin, Jia Woei Hou, Tzu Hao Wang, Yen An Tsai, Kai Wei Liao, I. Fang Mao, Mei Lien Chen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Nonylphenol (NP) has been proven as an endocrine disrupter and had the ability to interfere with the endocrine system. Though the health effects of NP on pregnant women and their fetuses are sustained, these negative associations related to the mechanisms of regulation for estrogen during pregnancy need to be further clarified. The objective of this study is to explore the association between maternal NP and hormonal levels, such as estradiol, testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH), and progesterone. Methods: A pregnant women cohort was established in North Taiwan between March and December 2010. Maternal urine and blood samples from the first, second, and third trimesters of gestation were collected. Urinary NP concentration was measured by high-performance liquid chromatography coupled with fluorescent detection. A mixed-effects model using a generalised estimating equation (GEE) was applied to assess the associations between maternal NP concentration and plasma hormones throughout the three trimesters. Results: In total, 162 singleton pregnant women completed this study through delivery. The geometric mean of creatinine-adjusted urinary NP concentrations were 4.27, 4.21, and 4.10 μg/g cre. in the first, second, and third trimesters respectively. A natural log-transformation of urinary NP concentrations were significantly associated with LH in the GEE model (β = -0.23 mIU/ml, p<0.01). Conclusion: This perspective cohort study demonstrates that negative association occurs between maternal NP exposure and plasma LH levels. The estrogen-mimic effect of NP might influence the negative feedback on LH during pregnancy.

Original languageEnglish
Article numbere104245
JournalPLoS ONE
Volume9
Issue number8
DOIs
Publication statusPublished - Aug 22 2014
Externally publishedYes

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Endocrine Disruptors
Phenols
Gonadal Steroid Hormones
Association reactions
Hormones
Luteinizing Hormone
Endocrine disrupters
Plasmas
nonylphenol
High performance liquid chromatography
Follicle Stimulating Hormone
Progesterone
Testosterone
Estradiol
Creatinine
Estrogens
Blood
Health
Feedback

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Chang, C. H., Tsai, M. S., Lin, C. L., Hou, J. W., Wang, T. H., Tsai, Y. A., ... Chen, M. L. (2014). The association between nonylphenols and sexual hormones levels among pregnant women: A cohort Study in Taiwan. PLoS ONE, 9(8), [e104245]. https://doi.org/10.1371/journal.pone.0104245

The association between nonylphenols and sexual hormones levels among pregnant women : A cohort Study in Taiwan. / Chang, Chia Huang; Tsai, Ming Song; Lin, Ching Ling; Hou, Jia Woei; Wang, Tzu Hao; Tsai, Yen An; Liao, Kai Wei; Mao, I. Fang; Chen, Mei Lien.

In: PLoS ONE, Vol. 9, No. 8, e104245, 22.08.2014.

Research output: Contribution to journalArticle

Chang, Chia Huang ; Tsai, Ming Song ; Lin, Ching Ling ; Hou, Jia Woei ; Wang, Tzu Hao ; Tsai, Yen An ; Liao, Kai Wei ; Mao, I. Fang ; Chen, Mei Lien. / The association between nonylphenols and sexual hormones levels among pregnant women : A cohort Study in Taiwan. In: PLoS ONE. 2014 ; Vol. 9, No. 8.
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