The association between Mycoplasma pneumoniae infection and speech and language impairment: A nationwide population-based study in Taiwan

Ching Shu Tsai, Vincent Chin Hung Chen, Yao Hsu Yang, Tai Hsin Hung, Mong Liang Lu, Kuo You Huang, Michael Gossop

Research output: Contribution to journalArticle

Abstract

Manifestations of Mycoplasma pneumoniae infection can range from self-limiting upper respiratory symptoms to various neurological complications, including speech and language impairment. But an association between Mycoplasma pneumoniae infection and speech and language impairment has not been sufficiently explored. In this study, we aim to investigate the association between Mycoplasma pneumoniae infection and subsequent speech and language impairment in a nationwide population-based sample using Taiwan’s National Health Insurance Research Database. We identified 5,406 children with Mycoplasma pneumoniae infection (International Classification of Disease, Revision 9, Clinical Modification code 4830) and compared to 21,624 age-, sex-, urban- and income-matched controls on subsequent speech and language impairment. The mean follow-up interval for all subjects was 6.44 years (standard deviation = 2.42 years); the mean latency period between the initial Mycoplasma pneumoniae infection and presence of speech and language impairment was 1.96 years (standard deviation = 1.64 years). The results showed that Mycoplasma pneumoniae infection was significantly associated with greater incidence of speech and language impairment [hazard ratio (HR) = 1.49, 95% CI: 1.23–1.80]. In addition, significantly increased hazard ratio of subsequent speech and language impairment in the groups younger than 6 years old and no significant difference in the groups over the age of 6 years were found (HR = 1.43, 95% CI: 1.09–1.88 for age 0–3 years group; HR = 1.67, 95% CI: 1.25–2.23 for age 4–5 years group; HR = 1.14, 95% CI: 0.54–2.39 for age 6–7 years group; and HR = 0.83, 95% CI: 0.23–2.92 for age 8–18 years group). In conclusion, Mycoplasma pneumoniae infection is temporally associated with incident speech and language impairment.

Original languageEnglish
Article numbere0180402
JournalPLoS One
Volume12
Issue number7
DOIs
Publication statusPublished - Jul 1 2017

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Mycoplasma pneumoniae
Taiwan
Language
Hazards
Infection
infection
Population
Health insurance
health insurance
National Health Programs
International Classification of Diseases
signs and symptoms (animals and humans)
income
Age Groups
Databases
incidence

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

The association between Mycoplasma pneumoniae infection and speech and language impairment : A nationwide population-based study in Taiwan. / Tsai, Ching Shu; Chen, Vincent Chin Hung; Yang, Yao Hsu; Hung, Tai Hsin; Lu, Mong Liang; Huang, Kuo You; Gossop, Michael.

In: PLoS One, Vol. 12, No. 7, e0180402, 01.07.2017.

Research output: Contribution to journalArticle

Tsai, Ching Shu ; Chen, Vincent Chin Hung ; Yang, Yao Hsu ; Hung, Tai Hsin ; Lu, Mong Liang ; Huang, Kuo You ; Gossop, Michael. / The association between Mycoplasma pneumoniae infection and speech and language impairment : A nationwide population-based study in Taiwan. In: PLoS One. 2017 ; Vol. 12, No. 7.
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abstract = "Manifestations of Mycoplasma pneumoniae infection can range from self-limiting upper respiratory symptoms to various neurological complications, including speech and language impairment. But an association between Mycoplasma pneumoniae infection and speech and language impairment has not been sufficiently explored. In this study, we aim to investigate the association between Mycoplasma pneumoniae infection and subsequent speech and language impairment in a nationwide population-based sample using Taiwan’s National Health Insurance Research Database. We identified 5,406 children with Mycoplasma pneumoniae infection (International Classification of Disease, Revision 9, Clinical Modification code 4830) and compared to 21,624 age-, sex-, urban- and income-matched controls on subsequent speech and language impairment. The mean follow-up interval for all subjects was 6.44 years (standard deviation = 2.42 years); the mean latency period between the initial Mycoplasma pneumoniae infection and presence of speech and language impairment was 1.96 years (standard deviation = 1.64 years). The results showed that Mycoplasma pneumoniae infection was significantly associated with greater incidence of speech and language impairment [hazard ratio (HR) = 1.49, 95{\%} CI: 1.23–1.80]. In addition, significantly increased hazard ratio of subsequent speech and language impairment in the groups younger than 6 years old and no significant difference in the groups over the age of 6 years were found (HR = 1.43, 95{\%} CI: 1.09–1.88 for age 0–3 years group; HR = 1.67, 95{\%} CI: 1.25–2.23 for age 4–5 years group; HR = 1.14, 95{\%} CI: 0.54–2.39 for age 6–7 years group; and HR = 0.83, 95{\%} CI: 0.23–2.92 for age 8–18 years group). In conclusion, Mycoplasma pneumoniae infection is temporally associated with incident speech and language impairment.",
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