The association between maternal nonylphenol exposure and parity on neonatal birth weight: A cohort study in Taiwan

Chia Huang Chang, Mei Lien Chen, Kai Wei Liao, Yen An Tsai, I. Fang Mao, Tzu Hao Wang, Shiaw Min Hwang, Yu Jen Chang, Ming Song Tsai

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: The aim of this study was to explore the association between NP exposure and parity and their effect on neonatal birth weight. Methods: A cohort of pregnant women was established in a medical center in North Taiwan. Urinary NP concentration was determined by high-performance liquid chromatography coupled with fluorescent detection and adjusted using creatinine. A multivariable regression model was fit to determine the association between the maternal NP level in each trimester and neonatal birth weight. The odds ratios (ORs) of infant birth weight below the 10th, 25th, and 50th percentiles, comparing pregnant women with the different NP exposure levels, was estimated using a logistic regression. Results: Of the 162 pregnant women in the study, 99 were multiparas and 63 were primiparas. After adjusting for other covariates, the NP level in the second trimester had a significant association with birth weight in the primiparas (β= -182.49. g, p value = 0.02). The OR of low infant birth weight, comparing pregnant women with different NP levels, was increased by decreasing the cutoff percentile for birth weight (OR = 1.18 for the 50th percentile, 2.12 for the 25th percentile, and 7.81 for the 10th percentile). The odds of primiparas with high NP level having a low neonatal birth weight increased to 3.87, 11.77, and 9.40 for the three different percentiles (p value <. 0.05). Conclusion: Maternal NP exposure level is associated with an increased risk of low neonatal weight. Primiparas are especially at risk, and the second trimester of pregnancy may be the critical stage of exposure.

Original languageEnglish
Pages (from-to)1145-1152
Number of pages8
JournalChemosphere
Volume93
Issue number6
DOIs
Publication statusPublished - Oct 1 2013
Externally publishedYes

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Environmental Pollutants
Phenols
Health risks
Liquid chromatography
High performance liquid chromatography
Regression analysis
Association reactions
Logistics
Creatinine
nonylphenol

Keywords

  • Birth weight
  • Nonylphenol
  • Pregnant woman
  • Primipara

ASJC Scopus subject areas

  • Environmental Chemistry
  • Chemistry(all)

Cite this

The association between maternal nonylphenol exposure and parity on neonatal birth weight : A cohort study in Taiwan. / Chang, Chia Huang; Chen, Mei Lien; Liao, Kai Wei; Tsai, Yen An; Mao, I. Fang; Wang, Tzu Hao; Hwang, Shiaw Min; Chang, Yu Jen; Tsai, Ming Song.

In: Chemosphere, Vol. 93, No. 6, 01.10.2013, p. 1145-1152.

Research output: Contribution to journalArticle

Chang, CH, Chen, ML, Liao, KW, Tsai, YA, Mao, IF, Wang, TH, Hwang, SM, Chang, YJ & Tsai, MS 2013, 'The association between maternal nonylphenol exposure and parity on neonatal birth weight: A cohort study in Taiwan', Chemosphere, vol. 93, no. 6, pp. 1145-1152. https://doi.org/10.1016/j.chemosphere.2013.06.048
Chang, Chia Huang ; Chen, Mei Lien ; Liao, Kai Wei ; Tsai, Yen An ; Mao, I. Fang ; Wang, Tzu Hao ; Hwang, Shiaw Min ; Chang, Yu Jen ; Tsai, Ming Song. / The association between maternal nonylphenol exposure and parity on neonatal birth weight : A cohort study in Taiwan. In: Chemosphere. 2013 ; Vol. 93, No. 6. pp. 1145-1152.
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AU - Chen, Mei Lien

AU - Liao, Kai Wei

AU - Tsai, Yen An

AU - Mao, I. Fang

AU - Wang, Tzu Hao

AU - Hwang, Shiaw Min

AU - Chang, Yu Jen

AU - Tsai, Ming Song

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N2 - Background: The aim of this study was to explore the association between NP exposure and parity and their effect on neonatal birth weight. Methods: A cohort of pregnant women was established in a medical center in North Taiwan. Urinary NP concentration was determined by high-performance liquid chromatography coupled with fluorescent detection and adjusted using creatinine. A multivariable regression model was fit to determine the association between the maternal NP level in each trimester and neonatal birth weight. The odds ratios (ORs) of infant birth weight below the 10th, 25th, and 50th percentiles, comparing pregnant women with the different NP exposure levels, was estimated using a logistic regression. Results: Of the 162 pregnant women in the study, 99 were multiparas and 63 were primiparas. After adjusting for other covariates, the NP level in the second trimester had a significant association with birth weight in the primiparas (β= -182.49. g, p value = 0.02). The OR of low infant birth weight, comparing pregnant women with different NP levels, was increased by decreasing the cutoff percentile for birth weight (OR = 1.18 for the 50th percentile, 2.12 for the 25th percentile, and 7.81 for the 10th percentile). The odds of primiparas with high NP level having a low neonatal birth weight increased to 3.87, 11.77, and 9.40 for the three different percentiles (p value <. 0.05). Conclusion: Maternal NP exposure level is associated with an increased risk of low neonatal weight. Primiparas are especially at risk, and the second trimester of pregnancy may be the critical stage of exposure.

AB - Background: The aim of this study was to explore the association between NP exposure and parity and their effect on neonatal birth weight. Methods: A cohort of pregnant women was established in a medical center in North Taiwan. Urinary NP concentration was determined by high-performance liquid chromatography coupled with fluorescent detection and adjusted using creatinine. A multivariable regression model was fit to determine the association between the maternal NP level in each trimester and neonatal birth weight. The odds ratios (ORs) of infant birth weight below the 10th, 25th, and 50th percentiles, comparing pregnant women with the different NP exposure levels, was estimated using a logistic regression. Results: Of the 162 pregnant women in the study, 99 were multiparas and 63 were primiparas. After adjusting for other covariates, the NP level in the second trimester had a significant association with birth weight in the primiparas (β= -182.49. g, p value = 0.02). The OR of low infant birth weight, comparing pregnant women with different NP levels, was increased by decreasing the cutoff percentile for birth weight (OR = 1.18 for the 50th percentile, 2.12 for the 25th percentile, and 7.81 for the 10th percentile). The odds of primiparas with high NP level having a low neonatal birth weight increased to 3.87, 11.77, and 9.40 for the three different percentiles (p value <. 0.05). Conclusion: Maternal NP exposure level is associated with an increased risk of low neonatal weight. Primiparas are especially at risk, and the second trimester of pregnancy may be the critical stage of exposure.

KW - Birth weight

KW - Nonylphenol

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KW - Primipara

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