The association between hypoxia inducible factor-1alpha gene polymorphisms and increased susceptibility to oral cancer

Mu Kuan Chen, Hui Ling Chiou, Shih Chi Su, Tsung Te Chung, Hsien Chun Tseng, Hsiu Ting Tsai, Shun Fa Yang

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

The aim of this study was to estimate the relations between hypoxia inducible factor-1α (HIF-1α) gene polymorphisms, C1772T and G1790A, to the susceptibility and clinicopathological status of oral cancer. A total of 521 subjects, including 347 controls and 174 oral cancer patients, were recruited in this study and subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to analyze the impact of these two polymorphic variants on oral cancer. A significant association between oral cancer susceptibility and G1790A polymorphism was demonstrated since individuals with heterozygotes, that is GA, had a higher risk for oral cancer, compared to GG genotypes after adjusting for other confounders (AOR = 3.31; 95%CI = 1.27-8.61). Compared to individuals with both C1772C and G1790G homozygotes, individuals with at least one of either C1772T or G1790A of HIF-1α gene had a risk of 2.17-folds (95% CI = 1.0-4.75) to develop oral cancer. Moreover, results also revealed the presence of synergistic effect between gene polymorphisms of HIF-1α and environmental risk factors, such as tobacco and betel nut consumptions while there was no significant association between HIF-1α gene polymorphism and clinicopathological parameters of oral cancer. Genetic polymorphism, including C1772T and G1790A, of HIF-1α is an important factor for the susceptibility to oral cancer.

Original languageEnglish
JournalOral Oncology
Volume45
Issue number12
DOIs
Publication statusPublished - Dec 2009
Externally publishedYes

Keywords

  • Betel nut chewing
  • Hypoxia inducible factor-1α
  • Oral cancer
  • Single nucleotide polymorphism
  • Tobacco consumption

ASJC Scopus subject areas

  • Oncology
  • Oral Surgery
  • Cancer Research

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