The Association between Biochemical Parameters and Sleep Related Disorders in Hemodialysis Patients

Jing-Yi Chen, Yen-Chung Lin, Hsi-Hsien Chen, Chih Chin Kao, Fan-Chi Chang, Tzen-Wen Chen, Mai-Szu Wu

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Abstract

BACKGROUND: Sleep disorders in long-term hemodialysis patients with comorbidities are common. They affect the quality of life and physical well-being of patients. However, little attention has been paid to this phenomenon. METHODS: Thirty-nine long-term hemodialysis patients with > 3 months of care at Taipei Medical University Hospital were prospectively enrolled. Participants’ biochemical data and sleep disorder scores were collected for analysis using questionnaire. Laboratory data were evaluated and scored by association, and further analyzed by both univariate and multivariate binary logistic regression analyses. RESULTS: The age range of the study population was 55.2 ± 11.1 years. In the correlation study, insomnia, determined by a higher Pittsburgh Sleep Quality Index (PSQI) score, was directly correlated with the severity of restless legs syndrome. After adjusting for age and sex in the multivariate analysis, a low serum creatinine level did not correlate with insomnia (P = 0.05); low serum sodium, potassium, and chloride levels strongly correlated with the severity of restless legs syndrome (P = 0.04, 0.02, and 0.003, respectively). Furthermore, elevated uric acid and fasting blood glucose levels were associated with depressed mood according to the Beck Depression Inventory (P = 0.012 and 0.024 respectively). However, only blood glucose level was associated with depressed mood according to the Center for Epidemiologic Studies Depression Scale (CESD) (P = 0.03). CONCLUSION: Biochemical differences exist between patients with sleep disorders and those without. In addition to impaired renal function and related electrolyte imbalance, metabolic problems such as hyperlipidemia and hyperuricemia may also affect the diagnosis of sleep disorders in hemodialysis patients. However, further research is warranted to confirm these results.
Original languageEnglish
Pages (from-to)79-86
Number of pages8
JournalActa Nephrologica
Volume30
Issue number2
Publication statusPublished - Jun 1 2016

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Renal Dialysis
Restless Legs Syndrome
Sleep Initiation and Maintenance Disorders
Blood Glucose
Depression
Hyperuricemia
Potassium Chloride
Hyperlipidemias
Uric Acid
Serum
Sodium Chloride
Electrolytes
Comorbidity
Epidemiologic Studies
Fasting
Creatinine
Sleep
Multivariate Analysis
Logistic Models
Regression Analysis

Keywords

  • depressive disorder
  • hemodialysis
  • insomnia
  • Restless legs syndrome/Willis-Ekbom disease
  • sleep disorder

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The Association between Biochemical Parameters and Sleep Related Disorders in Hemodialysis Patients. / Chen, Jing-Yi; Lin, Yen-Chung; Chen, Hsi-Hsien; Kao, Chih Chin; Chang, Fan-Chi; Chen, Tzen-Wen; Wu, Mai-Szu.

In: Acta Nephrologica, Vol. 30, No. 2, 01.06.2016, p. 79-86.

Research output: Contribution to journalArticle

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