The application of minimally invasive devices with nanostructured surface functionalization: Antisticking behavior on devices and liver tissue interface in rat

Li Hsiang Lin, Ya Ju Hsu, Hsi Jen Chiang, Han Yi Cheng, Che Shun Wang, Keng Liang Ou

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study investigated the thermal injury and adhesion property of a novel electrosurgery of liver using copper-doped diamond-like carbon (DLC-Cu) surface treatment. It is necessary to reduce the thermal damage of surrounding tissues for clinical electrosurgeries. The surface morphologies of stainless steel (SS) coated with DLC (DLC-Cu-SS) films were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Bionic liver models were reconstructed using magnetic resonance imaging (MRI) to simulate electrosurgery. Cell cytotoxicity assays showed that the DLC-Cu thin film was nontoxic. The temperature of tissue decreased significantly with use of the electrosurgical device with nanostructured DLC-Cu films and increased with increasing thickness of the films. Thermography revealed that the surgical temperature in the DLC-Cu-SS electrosurgical device was significantly lower than that in the untreated device in the animal model. Moreover, compared to the SS electrosurgical device, the DLC-Cu-SS electrosurgical device caused a relatively small injury area and lateral thermal effect. The results indicate that the DLC-Cu-SS electrosurgical device decreases excessive thermal injury and ensures homogeneous temperature transformation in the tissues.

Original languageEnglish
Article number357943
JournalJournal of Nanomaterials
Volume2015
DOIs
Publication statusPublished - 2015

Fingerprint

Stainless Steel
Liver
Rats
Electrosurgery
Stainless steel
Tissue
Bionics
Diamond
Magnetic resonance
Cytotoxicity
Thermal effects
Temperature
Surface morphology
Surface treatment
Copper
Assays
Diamonds
Animals
Carbon
Adhesion

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

The application of minimally invasive devices with nanostructured surface functionalization : Antisticking behavior on devices and liver tissue interface in rat. / Lin, Li Hsiang; Hsu, Ya Ju; Chiang, Hsi Jen; Cheng, Han Yi; Wang, Che Shun; Ou, Keng Liang.

In: Journal of Nanomaterials, Vol. 2015, 357943, 2015.

Research output: Contribution to journalArticle

Lin, Li Hsiang ; Hsu, Ya Ju ; Chiang, Hsi Jen ; Cheng, Han Yi ; Wang, Che Shun ; Ou, Keng Liang. / The application of minimally invasive devices with nanostructured surface functionalization : Antisticking behavior on devices and liver tissue interface in rat. In: Journal of Nanomaterials. 2015 ; Vol. 2015.
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