The antinociceptive effect of nalbuphine and its long-acting esters in rats

Koung Shing Chu, Jhi Joung Wang, Oliver Yoa Pu Hu, Shung Tai Ho, Yu Wen Chen

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A long-acting analgesic is particularly desirable in patients with long-lasting pain. In this study, we evaluated the antinociceptive effect and duration of action of three nalbuphine esters - nalbuphine propionate, enanthate, and decanoate - and observed whether these esters had a long-acting effect. Male Sprague-Dawley rats (n = 12 in each group) were used. Two studies were performed. In Study 1, we evaluated the antinociceptive effect of IM nalbuphine HCl with dosages of 0.25, 1.25, 2.5, 25, and 250 μmol/kg. In Study 2, we evaluated the antinociceptive effects of IM nalbuphine base and esters with a dosage of 25 μmol/kg. After 2.5, 25, and 250 μmol/kg IM injections, we found that nalbuphine HCl produced a dose-related antinociceptive effect with durations of action of 1.5, 2, and 4 h, respectively. After a 25 μmol/kg IM injection, the durations of action of the nalbuphine esters, nalbuphine propionate, enanthate, and decanoate were 5, 30, and 60 h, respectively. We conclude that, on an equimolar basis, nalbuphine esters produce relatively longer durations of action than nalbuphine HCl.

Original languageEnglish
Pages (from-to)806-809
Number of pages4
JournalAnesthesia and Analgesia
Volume97
Issue number3
Publication statusPublished - Sep 1 2003
Externally publishedYes

Fingerprint

Nalbuphine
Esters
Heptanoates
Decanoates
Propionates
Injections
Sprague Dawley Rats
Analgesics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Chu, K. S., Wang, J. J., Hu, O. Y. P., Ho, S. T., & Chen, Y. W. (2003). The antinociceptive effect of nalbuphine and its long-acting esters in rats. Anesthesia and Analgesia, 97(3), 806-809.

The antinociceptive effect of nalbuphine and its long-acting esters in rats. / Chu, Koung Shing; Wang, Jhi Joung; Hu, Oliver Yoa Pu; Ho, Shung Tai; Chen, Yu Wen.

In: Anesthesia and Analgesia, Vol. 97, No. 3, 01.09.2003, p. 806-809.

Research output: Contribution to journalArticle

Chu, KS, Wang, JJ, Hu, OYP, Ho, ST & Chen, YW 2003, 'The antinociceptive effect of nalbuphine and its long-acting esters in rats', Anesthesia and Analgesia, vol. 97, no. 3, pp. 806-809.
Chu KS, Wang JJ, Hu OYP, Ho ST, Chen YW. The antinociceptive effect of nalbuphine and its long-acting esters in rats. Anesthesia and Analgesia. 2003 Sep 1;97(3):806-809.
Chu, Koung Shing ; Wang, Jhi Joung ; Hu, Oliver Yoa Pu ; Ho, Shung Tai ; Chen, Yu Wen. / The antinociceptive effect of nalbuphine and its long-acting esters in rats. In: Anesthesia and Analgesia. 2003 ; Vol. 97, No. 3. pp. 806-809.
@article{96a8c92aae5b47099cad0a12b88e7cc3,
title = "The antinociceptive effect of nalbuphine and its long-acting esters in rats",
abstract = "A long-acting analgesic is particularly desirable in patients with long-lasting pain. In this study, we evaluated the antinociceptive effect and duration of action of three nalbuphine esters - nalbuphine propionate, enanthate, and decanoate - and observed whether these esters had a long-acting effect. Male Sprague-Dawley rats (n = 12 in each group) were used. Two studies were performed. In Study 1, we evaluated the antinociceptive effect of IM nalbuphine HCl with dosages of 0.25, 1.25, 2.5, 25, and 250 μmol/kg. In Study 2, we evaluated the antinociceptive effects of IM nalbuphine base and esters with a dosage of 25 μmol/kg. After 2.5, 25, and 250 μmol/kg IM injections, we found that nalbuphine HCl produced a dose-related antinociceptive effect with durations of action of 1.5, 2, and 4 h, respectively. After a 25 μmol/kg IM injection, the durations of action of the nalbuphine esters, nalbuphine propionate, enanthate, and decanoate were 5, 30, and 60 h, respectively. We conclude that, on an equimolar basis, nalbuphine esters produce relatively longer durations of action than nalbuphine HCl.",
author = "Chu, {Koung Shing} and Wang, {Jhi Joung} and Hu, {Oliver Yoa Pu} and Ho, {Shung Tai} and Chen, {Yu Wen}",
year = "2003",
month = "9",
day = "1",
language = "English",
volume = "97",
pages = "806--809",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - The antinociceptive effect of nalbuphine and its long-acting esters in rats

AU - Chu, Koung Shing

AU - Wang, Jhi Joung

AU - Hu, Oliver Yoa Pu

AU - Ho, Shung Tai

AU - Chen, Yu Wen

PY - 2003/9/1

Y1 - 2003/9/1

N2 - A long-acting analgesic is particularly desirable in patients with long-lasting pain. In this study, we evaluated the antinociceptive effect and duration of action of three nalbuphine esters - nalbuphine propionate, enanthate, and decanoate - and observed whether these esters had a long-acting effect. Male Sprague-Dawley rats (n = 12 in each group) were used. Two studies were performed. In Study 1, we evaluated the antinociceptive effect of IM nalbuphine HCl with dosages of 0.25, 1.25, 2.5, 25, and 250 μmol/kg. In Study 2, we evaluated the antinociceptive effects of IM nalbuphine base and esters with a dosage of 25 μmol/kg. After 2.5, 25, and 250 μmol/kg IM injections, we found that nalbuphine HCl produced a dose-related antinociceptive effect with durations of action of 1.5, 2, and 4 h, respectively. After a 25 μmol/kg IM injection, the durations of action of the nalbuphine esters, nalbuphine propionate, enanthate, and decanoate were 5, 30, and 60 h, respectively. We conclude that, on an equimolar basis, nalbuphine esters produce relatively longer durations of action than nalbuphine HCl.

AB - A long-acting analgesic is particularly desirable in patients with long-lasting pain. In this study, we evaluated the antinociceptive effect and duration of action of three nalbuphine esters - nalbuphine propionate, enanthate, and decanoate - and observed whether these esters had a long-acting effect. Male Sprague-Dawley rats (n = 12 in each group) were used. Two studies were performed. In Study 1, we evaluated the antinociceptive effect of IM nalbuphine HCl with dosages of 0.25, 1.25, 2.5, 25, and 250 μmol/kg. In Study 2, we evaluated the antinociceptive effects of IM nalbuphine base and esters with a dosage of 25 μmol/kg. After 2.5, 25, and 250 μmol/kg IM injections, we found that nalbuphine HCl produced a dose-related antinociceptive effect with durations of action of 1.5, 2, and 4 h, respectively. After a 25 μmol/kg IM injection, the durations of action of the nalbuphine esters, nalbuphine propionate, enanthate, and decanoate were 5, 30, and 60 h, respectively. We conclude that, on an equimolar basis, nalbuphine esters produce relatively longer durations of action than nalbuphine HCl.

UR - http://www.scopus.com/inward/record.url?scp=0042329337&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042329337&partnerID=8YFLogxK

M3 - Article

C2 - 12933406

AN - SCOPUS:0042329337

VL - 97

SP - 806

EP - 809

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 3

ER -