The antinociceptive effect of a long-acting nalbuphine preparation in rabbits

Shung Tai Ho, Jhi Joung Wang, Oliver Yoa Pu Hu, Jann Inn Tzeng, Kuo Sheng Liu, Tu Wen Chen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: An analgesic with a long-lasting effect is particularly desirable to patients suffering from long-standing pain. The aim of this study was to evaluate the antinociceptive effect and duration of action of an oily dosage form of nalbuphine base and to see whether its effect could last longer compared with nalbuphine HCl. Methods: Male New Zealand White rabbits (n = 6 in each group) were used. Two studies were carried out. In study 1, we evaluated the antinociceptive effect of intramuscular nalbuphine HC1 (in saline) with dosages of 25, 50, and 100 μmol/kg. In study 2, we evaluated the antinociceptive effects of intramuscular nalbuphine base (in sesame oil) with dosages of 100, 200, and 400 μmol/kg. In these studies, the vehicles (saline or sesame oil) were used as controls. A paw pressure test was used to detect the antinociceptive effect of the testing drugs. Results: We found that nalbuphine HCl 25, 50 and 100 μmol/kg produced a dose-related antinociceptive effect with durations of action of 1, 1, and 1.3 h, respectively. Nalbuphine base 100, 200 and 400 μmol/kg also produced a dose-related antinociceptive effect but with longer durations of action of 8, 24, and 48 h, respectively. On an equimolar basis (100 μmol/kg), nalbuphine base produced a 6-fold increase in the duration of action than did nalbuphine HCl. Conclusions: We conclude that intramuscular nalbuphine base produced a relatively longer duration of action than did intramuscular nalbuphine HCl.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalActa Anaesthesiologica Sinica
Volume41
Issue number3
Publication statusPublished - Sep 1 2003
Externally publishedYes

Fingerprint

Nalbuphine
Rabbits
Sesame Oil
Dosage Forms
Analgesics

Keywords

  • Analgesics
  • Long-acting preparations
  • Nalbuphine

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Ho, S. T., Wang, J. J., Hu, O. Y. P., Tzeng, J. I., Liu, K. S., & Chen, T. W. (2003). The antinociceptive effect of a long-acting nalbuphine preparation in rabbits. Acta Anaesthesiologica Sinica, 41(3), 99-103.

The antinociceptive effect of a long-acting nalbuphine preparation in rabbits. / Ho, Shung Tai; Wang, Jhi Joung; Hu, Oliver Yoa Pu; Tzeng, Jann Inn; Liu, Kuo Sheng; Chen, Tu Wen.

In: Acta Anaesthesiologica Sinica, Vol. 41, No. 3, 01.09.2003, p. 99-103.

Research output: Contribution to journalArticle

Ho, ST, Wang, JJ, Hu, OYP, Tzeng, JI, Liu, KS & Chen, TW 2003, 'The antinociceptive effect of a long-acting nalbuphine preparation in rabbits', Acta Anaesthesiologica Sinica, vol. 41, no. 3, pp. 99-103.
Ho ST, Wang JJ, Hu OYP, Tzeng JI, Liu KS, Chen TW. The antinociceptive effect of a long-acting nalbuphine preparation in rabbits. Acta Anaesthesiologica Sinica. 2003 Sep 1;41(3):99-103.
Ho, Shung Tai ; Wang, Jhi Joung ; Hu, Oliver Yoa Pu ; Tzeng, Jann Inn ; Liu, Kuo Sheng ; Chen, Tu Wen. / The antinociceptive effect of a long-acting nalbuphine preparation in rabbits. In: Acta Anaesthesiologica Sinica. 2003 ; Vol. 41, No. 3. pp. 99-103.
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abstract = "Background: An analgesic with a long-lasting effect is particularly desirable to patients suffering from long-standing pain. The aim of this study was to evaluate the antinociceptive effect and duration of action of an oily dosage form of nalbuphine base and to see whether its effect could last longer compared with nalbuphine HCl. Methods: Male New Zealand White rabbits (n = 6 in each group) were used. Two studies were carried out. In study 1, we evaluated the antinociceptive effect of intramuscular nalbuphine HC1 (in saline) with dosages of 25, 50, and 100 μmol/kg. In study 2, we evaluated the antinociceptive effects of intramuscular nalbuphine base (in sesame oil) with dosages of 100, 200, and 400 μmol/kg. In these studies, the vehicles (saline or sesame oil) were used as controls. A paw pressure test was used to detect the antinociceptive effect of the testing drugs. Results: We found that nalbuphine HCl 25, 50 and 100 μmol/kg produced a dose-related antinociceptive effect with durations of action of 1, 1, and 1.3 h, respectively. Nalbuphine base 100, 200 and 400 μmol/kg also produced a dose-related antinociceptive effect but with longer durations of action of 8, 24, and 48 h, respectively. On an equimolar basis (100 μmol/kg), nalbuphine base produced a 6-fold increase in the duration of action than did nalbuphine HCl. Conclusions: We conclude that intramuscular nalbuphine base produced a relatively longer duration of action than did intramuscular nalbuphine HCl.",
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AU - Chen, Tu Wen

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N2 - Background: An analgesic with a long-lasting effect is particularly desirable to patients suffering from long-standing pain. The aim of this study was to evaluate the antinociceptive effect and duration of action of an oily dosage form of nalbuphine base and to see whether its effect could last longer compared with nalbuphine HCl. Methods: Male New Zealand White rabbits (n = 6 in each group) were used. Two studies were carried out. In study 1, we evaluated the antinociceptive effect of intramuscular nalbuphine HC1 (in saline) with dosages of 25, 50, and 100 μmol/kg. In study 2, we evaluated the antinociceptive effects of intramuscular nalbuphine base (in sesame oil) with dosages of 100, 200, and 400 μmol/kg. In these studies, the vehicles (saline or sesame oil) were used as controls. A paw pressure test was used to detect the antinociceptive effect of the testing drugs. Results: We found that nalbuphine HCl 25, 50 and 100 μmol/kg produced a dose-related antinociceptive effect with durations of action of 1, 1, and 1.3 h, respectively. Nalbuphine base 100, 200 and 400 μmol/kg also produced a dose-related antinociceptive effect but with longer durations of action of 8, 24, and 48 h, respectively. On an equimolar basis (100 μmol/kg), nalbuphine base produced a 6-fold increase in the duration of action than did nalbuphine HCl. Conclusions: We conclude that intramuscular nalbuphine base produced a relatively longer duration of action than did intramuscular nalbuphine HCl.

AB - Background: An analgesic with a long-lasting effect is particularly desirable to patients suffering from long-standing pain. The aim of this study was to evaluate the antinociceptive effect and duration of action of an oily dosage form of nalbuphine base and to see whether its effect could last longer compared with nalbuphine HCl. Methods: Male New Zealand White rabbits (n = 6 in each group) were used. Two studies were carried out. In study 1, we evaluated the antinociceptive effect of intramuscular nalbuphine HC1 (in saline) with dosages of 25, 50, and 100 μmol/kg. In study 2, we evaluated the antinociceptive effects of intramuscular nalbuphine base (in sesame oil) with dosages of 100, 200, and 400 μmol/kg. In these studies, the vehicles (saline or sesame oil) were used as controls. A paw pressure test was used to detect the antinociceptive effect of the testing drugs. Results: We found that nalbuphine HCl 25, 50 and 100 μmol/kg produced a dose-related antinociceptive effect with durations of action of 1, 1, and 1.3 h, respectively. Nalbuphine base 100, 200 and 400 μmol/kg also produced a dose-related antinociceptive effect but with longer durations of action of 8, 24, and 48 h, respectively. On an equimolar basis (100 μmol/kg), nalbuphine base produced a 6-fold increase in the duration of action than did nalbuphine HCl. Conclusions: We conclude that intramuscular nalbuphine base produced a relatively longer duration of action than did intramuscular nalbuphine HCl.

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