The antihypertensive effect of the berberine derivative 6-protoberberine in spontaneously hypertensive rats

Ju Chi Liu, Paul Chan, Yi Jen Chen, Brian Tomlinson, Sheu Fang Hong, Juei Tang Cheng

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Berberine is a natural isoquinoline alkaloid found in plants of the Ranunculaceae and Berberidaceae families. Extracts from berberine-containing plants have been used as traditional Chinese folk remedies for centuries. The antihypertensive effects of the herberine derivative 6-protoberberine (PTB-6) were studied in spontaneously hypertensive rats (SHRs). In conscious SHRs, PTB-6 lowered the systolic blood pressure in a dose-dependent manner (6-PTB: 5 mg/kg, -31.1 ± 1.6 mmHg; 10 mg/kg, -42.4 ± 3.1 mmHg). Cardiac output using the thermodilution method was reduced in PTB-6-treated anesthetized SHRs with a tendency to decrease in heart rate. Injection of PTB-6 into the intraceral ventricles of SHRs lowered the systolic arterial blood pressure and heart rate. The berberine derivative PTB-6 is an effective antihypertensive agent. The mechanism of the antihypertensive effect of PTB-6 is probably through a central sympatholytic effect.

Original languageEnglish
Pages (from-to)283-289
Number of pages7
JournalPharmacology
Volume59
Issue number6
Publication statusPublished - Dec 1999

Fingerprint

Berberine
Inbred SHR Rats
Antihypertensive Agents
Berberidaceae
Heart Rate
Ranunculaceae
Sympatholytics
Blood Pressure
Thermodilution
Traditional Medicine
Alkaloids
Cardiac Output
Arterial Pressure
Injections
protoberberine

Keywords

  • Berberine
  • Protoberberine
  • Spontaneously hypertensive rats

ASJC Scopus subject areas

  • Pharmacology

Cite this

The antihypertensive effect of the berberine derivative 6-protoberberine in spontaneously hypertensive rats. / Liu, Ju Chi; Chan, Paul; Chen, Yi Jen; Tomlinson, Brian; Hong, Sheu Fang; Cheng, Juei Tang.

In: Pharmacology, Vol. 59, No. 6, 12.1999, p. 283-289.

Research output: Contribution to journalArticle

@article{cc2af86069e240d5b33103958addba9c,
title = "The antihypertensive effect of the berberine derivative 6-protoberberine in spontaneously hypertensive rats",
abstract = "Berberine is a natural isoquinoline alkaloid found in plants of the Ranunculaceae and Berberidaceae families. Extracts from berberine-containing plants have been used as traditional Chinese folk remedies for centuries. The antihypertensive effects of the herberine derivative 6-protoberberine (PTB-6) were studied in spontaneously hypertensive rats (SHRs). In conscious SHRs, PTB-6 lowered the systolic blood pressure in a dose-dependent manner (6-PTB: 5 mg/kg, -31.1 ± 1.6 mmHg; 10 mg/kg, -42.4 ± 3.1 mmHg). Cardiac output using the thermodilution method was reduced in PTB-6-treated anesthetized SHRs with a tendency to decrease in heart rate. Injection of PTB-6 into the intraceral ventricles of SHRs lowered the systolic arterial blood pressure and heart rate. The berberine derivative PTB-6 is an effective antihypertensive agent. The mechanism of the antihypertensive effect of PTB-6 is probably through a central sympatholytic effect.",
keywords = "Berberine, Protoberberine, Spontaneously hypertensive rats",
author = "Liu, {Ju Chi} and Paul Chan and Chen, {Yi Jen} and Brian Tomlinson and Hong, {Sheu Fang} and Cheng, {Juei Tang}",
year = "1999",
month = "12",
language = "English",
volume = "59",
pages = "283--289",
journal = "Pharmacology",
issn = "0031-7012",
publisher = "S. Karger AG",
number = "6",

}

TY - JOUR

T1 - The antihypertensive effect of the berberine derivative 6-protoberberine in spontaneously hypertensive rats

AU - Liu, Ju Chi

AU - Chan, Paul

AU - Chen, Yi Jen

AU - Tomlinson, Brian

AU - Hong, Sheu Fang

AU - Cheng, Juei Tang

PY - 1999/12

Y1 - 1999/12

N2 - Berberine is a natural isoquinoline alkaloid found in plants of the Ranunculaceae and Berberidaceae families. Extracts from berberine-containing plants have been used as traditional Chinese folk remedies for centuries. The antihypertensive effects of the herberine derivative 6-protoberberine (PTB-6) were studied in spontaneously hypertensive rats (SHRs). In conscious SHRs, PTB-6 lowered the systolic blood pressure in a dose-dependent manner (6-PTB: 5 mg/kg, -31.1 ± 1.6 mmHg; 10 mg/kg, -42.4 ± 3.1 mmHg). Cardiac output using the thermodilution method was reduced in PTB-6-treated anesthetized SHRs with a tendency to decrease in heart rate. Injection of PTB-6 into the intraceral ventricles of SHRs lowered the systolic arterial blood pressure and heart rate. The berberine derivative PTB-6 is an effective antihypertensive agent. The mechanism of the antihypertensive effect of PTB-6 is probably through a central sympatholytic effect.

AB - Berberine is a natural isoquinoline alkaloid found in plants of the Ranunculaceae and Berberidaceae families. Extracts from berberine-containing plants have been used as traditional Chinese folk remedies for centuries. The antihypertensive effects of the herberine derivative 6-protoberberine (PTB-6) were studied in spontaneously hypertensive rats (SHRs). In conscious SHRs, PTB-6 lowered the systolic blood pressure in a dose-dependent manner (6-PTB: 5 mg/kg, -31.1 ± 1.6 mmHg; 10 mg/kg, -42.4 ± 3.1 mmHg). Cardiac output using the thermodilution method was reduced in PTB-6-treated anesthetized SHRs with a tendency to decrease in heart rate. Injection of PTB-6 into the intraceral ventricles of SHRs lowered the systolic arterial blood pressure and heart rate. The berberine derivative PTB-6 is an effective antihypertensive agent. The mechanism of the antihypertensive effect of PTB-6 is probably through a central sympatholytic effect.

KW - Berberine

KW - Protoberberine

KW - Spontaneously hypertensive rats

UR - http://www.scopus.com/inward/record.url?scp=0032758164&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032758164&partnerID=8YFLogxK

M3 - Article

C2 - 10575322

AN - SCOPUS:0032758164

VL - 59

SP - 283

EP - 289

JO - Pharmacology

JF - Pharmacology

SN - 0031-7012

IS - 6

ER -