The Anti-Proliferative Activity of Secondary Metabolite from the Marine Streptomyces sp. against Prostate Cancer Cells

Hung Yu Lin, Yong Shiou Lin, Shou Ping Shih, Sung Bau Lee, Mohamed El-Shazly, Ken Ming Chang, Yu Chen S.H. Yang, Yi Lun Lee, Mei Chin Lu

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Many active substances from marine organisms are produced by symbiotic microorganisms such as bacteria, fungi, and algae. Secondary metabolites from marine actinomycetes exhibited several biological activities and provided interesting drug leads. This study reported the isolation of Lu01-M, a secondary metabolite from the marine actinomycetes Streptomyces sp., with potent anti-proliferative activity against prostate cancers. Lu01-M blocked cell proliferation with IC50 values of 1.03 ± 0.31, 2.12 ± 0.38, 1.27 ± 0.25 µg/mL in human prostate cancer PC3, DU145, and LNCaP cells, respectively. Lu01-M induced cytotoxic activity through multiple mechanisms including cell apoptosis, necroptosis, autophagy, ER stress, and inhibiting colony formation and cell migration. Lu01-M induced cell cycle arrest at the G2/M phase and DNA damage. However, the activity of autophagy induced survival response in cancer cells. Our findings suggested that Lu01-M holds the potential to be developed as an anti-cancer agent against prostate cancers.

Original languageEnglish
Article number1414
JournalLife
Volume11
Issue number12
DOIs
Publication statusPublished - Dec 2021

Keywords

  • Lu01-M
  • Marine actinomycetes
  • Prostate cancer
  • Streptomyces sp

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Space and Planetary Science
  • Palaeontology

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