Abstract

Background: MNS16A is a functional polymorphic tandem repeat in the human telomerase reverse transcriptase (hTERT). Its variant (long-long, LL genotype) has been associated with an increased risk for developing lung cancer in Caucasians. The aim of this study was to investigate the distribution of MNS16A genotypes in non-small cell lung cancers and whether these variant genotypes represent a genetic risk factor for lung cancer in Taiwan. Methods: A retrospective case study and the genotypes of MNS16A were compared between 205 lung cancer patients and 219 normal individuals using conventional polymerase chain reactions. Results: In the Taiwanese population, the distribution of the MNS16A variants LL and LS was 89.95% and 10.06%, respectively; less than 1% of our study population had the SS genotype. Statistical analysis revealed that MNS16A variants were not associated with an increased risk for lung cancer, after stratification for age, sex, pathology, stages, smoking history, or the presence of epidermal growth factor receptor mutations. Conclusion: In contrast with the early study obtained from the Caucasian population, MNS16A polymorphisms might not be a key genetic risk factor for developing non-small cell lung cancer in the Taiwanese population.

Original languageEnglish
Pages (from-to)293-295
Number of pages3
JournalJournal of Experimental and Clinical Medicine(Taiwan)
Volume3
Issue number6
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Non-Small Cell Lung Carcinoma
Genotype
Lung Neoplasms
Population
Tandem Repeat Sequences
Taiwan
Epidermal Growth Factor Receptor
Retrospective Studies
Smoking
History
Demography
human TERT protein
Pathology
Polymerase Chain Reaction
Mutation

Keywords

  • EGFR mutations
  • Lung cancer risk factor
  • MNS16A polymorphisms
  • Non-small cell lung cancer
  • Taiwanese population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{b052100846be49f29b4217f0e424fc4e,
title = "The analysis between functional human telomerase reverse transcriptase MNS16A polymorphisms and the risk of developing non-small cell lung cancer in the taiwanese population",
abstract = "Background: MNS16A is a functional polymorphic tandem repeat in the human telomerase reverse transcriptase (hTERT). Its variant (long-long, LL genotype) has been associated with an increased risk for developing lung cancer in Caucasians. The aim of this study was to investigate the distribution of MNS16A genotypes in non-small cell lung cancers and whether these variant genotypes represent a genetic risk factor for lung cancer in Taiwan. Methods: A retrospective case study and the genotypes of MNS16A were compared between 205 lung cancer patients and 219 normal individuals using conventional polymerase chain reactions. Results: In the Taiwanese population, the distribution of the MNS16A variants LL and LS was 89.95{\%} and 10.06{\%}, respectively; less than 1{\%} of our study population had the SS genotype. Statistical analysis revealed that MNS16A variants were not associated with an increased risk for lung cancer, after stratification for age, sex, pathology, stages, smoking history, or the presence of epidermal growth factor receptor mutations. Conclusion: In contrast with the early study obtained from the Caucasian population, MNS16A polymorphisms might not be a key genetic risk factor for developing non-small cell lung cancer in the Taiwanese population.",
keywords = "EGFR mutations, Lung cancer risk factor, MNS16A polymorphisms, Non-small cell lung cancer, Taiwanese population",
author = "Chang, {Chih Cheng} and Yu, {Ming Chih} and Bai, {Kuan Jen} and Chang, {Jer Hwa} and Lee, {Chun Nee} and Fang, {Chia Lang} and Liu, {H. Eugene}",
year = "2011",
month = "12",
doi = "10.1016/j.jecm.2011.10.012",
language = "English",
volume = "3",
pages = "293--295",
journal = "Journal of Experimental and Clinical Medicine",
issn = "1878-3317",
publisher = "Elsevier Taiwan LLC",
number = "6",

}

TY - JOUR

T1 - The analysis between functional human telomerase reverse transcriptase MNS16A polymorphisms and the risk of developing non-small cell lung cancer in the taiwanese population

AU - Chang, Chih Cheng

AU - Yu, Ming Chih

AU - Bai, Kuan Jen

AU - Chang, Jer Hwa

AU - Lee, Chun Nee

AU - Fang, Chia Lang

AU - Liu, H. Eugene

PY - 2011/12

Y1 - 2011/12

N2 - Background: MNS16A is a functional polymorphic tandem repeat in the human telomerase reverse transcriptase (hTERT). Its variant (long-long, LL genotype) has been associated with an increased risk for developing lung cancer in Caucasians. The aim of this study was to investigate the distribution of MNS16A genotypes in non-small cell lung cancers and whether these variant genotypes represent a genetic risk factor for lung cancer in Taiwan. Methods: A retrospective case study and the genotypes of MNS16A were compared between 205 lung cancer patients and 219 normal individuals using conventional polymerase chain reactions. Results: In the Taiwanese population, the distribution of the MNS16A variants LL and LS was 89.95% and 10.06%, respectively; less than 1% of our study population had the SS genotype. Statistical analysis revealed that MNS16A variants were not associated with an increased risk for lung cancer, after stratification for age, sex, pathology, stages, smoking history, or the presence of epidermal growth factor receptor mutations. Conclusion: In contrast with the early study obtained from the Caucasian population, MNS16A polymorphisms might not be a key genetic risk factor for developing non-small cell lung cancer in the Taiwanese population.

AB - Background: MNS16A is a functional polymorphic tandem repeat in the human telomerase reverse transcriptase (hTERT). Its variant (long-long, LL genotype) has been associated with an increased risk for developing lung cancer in Caucasians. The aim of this study was to investigate the distribution of MNS16A genotypes in non-small cell lung cancers and whether these variant genotypes represent a genetic risk factor for lung cancer in Taiwan. Methods: A retrospective case study and the genotypes of MNS16A were compared between 205 lung cancer patients and 219 normal individuals using conventional polymerase chain reactions. Results: In the Taiwanese population, the distribution of the MNS16A variants LL and LS was 89.95% and 10.06%, respectively; less than 1% of our study population had the SS genotype. Statistical analysis revealed that MNS16A variants were not associated with an increased risk for lung cancer, after stratification for age, sex, pathology, stages, smoking history, or the presence of epidermal growth factor receptor mutations. Conclusion: In contrast with the early study obtained from the Caucasian population, MNS16A polymorphisms might not be a key genetic risk factor for developing non-small cell lung cancer in the Taiwanese population.

KW - EGFR mutations

KW - Lung cancer risk factor

KW - MNS16A polymorphisms

KW - Non-small cell lung cancer

KW - Taiwanese population

UR - http://www.scopus.com/inward/record.url?scp=83555177194&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=83555177194&partnerID=8YFLogxK

U2 - 10.1016/j.jecm.2011.10.012

DO - 10.1016/j.jecm.2011.10.012

M3 - Article

AN - SCOPUS:83555177194

VL - 3

SP - 293

EP - 295

JO - Journal of Experimental and Clinical Medicine

JF - Journal of Experimental and Clinical Medicine

SN - 1878-3317

IS - 6

ER -