The analgesic effect of nalbuphine and its long-acting prodrug, nalbuphine arachidicate, in rats

Kuo Feng Huang, Yoa Pu Hu, Shung Tai Ho, Yi Ling Chen, Jhi Joung Wang

Research output: Contribution to journalArticle

Abstract

Nalbuphine is an opioid-analgesic with agonist-antagonist properties. Recently, we synthesized a nalbuphine prodrug, nalbuphine arachidicate. The aim of the present study was to evaluate the analgesic effect and the analgesic duration of this prodrug. Male Sprague-Dawley rats (n=10 in each group) were used. Nalbuphine arachidicate was prepared in an oily solution dosage form and injected intramuscularly at a dosage of 25 μmol/kg. A nalbuphine HCl solution was injected intramuscularly at a dosage of 25 μmol/kg in the control group. The analgesic effect of nalbuphine arachidicate was assessed using the cold-ethanol tail-flick test (-20°C) and compared with that of nalbuphine HCl. The results show that both nalbuphine arachidicate and nalbuphine HCl demonstrate significant analgesic effects. The analgesic duration of nalbuphine arachidicate (78 h) was much longer than that of nalbuphine HCl (2 h). This fascinating finding is worthy of further evaluation.

Original languageEnglish
Pages (from-to)283-289
Number of pages7
JournalFormosan Journal of Surgery
Volume35
Issue number6
Publication statusPublished - Jan 1 2002
Externally publishedYes

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Nalbuphine
Prodrugs
Analgesics
Dosage Forms
Opioid Analgesics
Sprague Dawley Rats
Tail

Keywords

  • Analgesia
  • Long-acting
  • Nalbuphine
  • Nalbuphine arachidicate
  • Prodrug

ASJC Scopus subject areas

  • Surgery

Cite this

Huang, K. F., Hu, Y. P., Ho, S. T., Chen, Y. L., & Wang, J. J. (2002). The analgesic effect of nalbuphine and its long-acting prodrug, nalbuphine arachidicate, in rats. Formosan Journal of Surgery, 35(6), 283-289.

The analgesic effect of nalbuphine and its long-acting prodrug, nalbuphine arachidicate, in rats. / Huang, Kuo Feng; Hu, Yoa Pu; Ho, Shung Tai; Chen, Yi Ling; Wang, Jhi Joung.

In: Formosan Journal of Surgery, Vol. 35, No. 6, 01.01.2002, p. 283-289.

Research output: Contribution to journalArticle

Huang, KF, Hu, YP, Ho, ST, Chen, YL & Wang, JJ 2002, 'The analgesic effect of nalbuphine and its long-acting prodrug, nalbuphine arachidicate, in rats', Formosan Journal of Surgery, vol. 35, no. 6, pp. 283-289.
Huang, Kuo Feng ; Hu, Yoa Pu ; Ho, Shung Tai ; Chen, Yi Ling ; Wang, Jhi Joung. / The analgesic effect of nalbuphine and its long-acting prodrug, nalbuphine arachidicate, in rats. In: Formosan Journal of Surgery. 2002 ; Vol. 35, No. 6. pp. 283-289.
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