Thaliporphine derivative improves acute lung injury after traumatic brain injury

Gunng Shinng Chen, Kuo Feng Huang, Chien Chu Huang, Jia Yi Wang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Acute lung injury (ALI) occurs frequently in patients with severe traumatic brain injury (TBI) and is associated with a poor clinical outcome. Aquaporins (AQPs), particularly AQP1 and AQP4, maintain water balances between the epithelial and microvascular domains of the lung. Since pulmonary edema (PE) usually occurs in the TBI-induced ALI patients, we investigated the effects of a thaliporphine derivative, TM-1, on the expression of AQPs and histological outcomes in the lung following TBI in rats. TM-1 administered (10 mg/kg, intraperitoneal injection) at 3 or 4 h after TBI significantly reduced the elevated mRNA expression and protein levels of AQP1 and AQP4 and diminished the wet/dry weight ratio, which reflects PE, in the lung at 8 and 24 h after TBI. Postinjury TM-1 administration also improved histopathological changes at 8 and 24 h after TBI. PE was accompanied with tissue pathological changes because a positive correlation between the lung injury score and the wet/dry weight ratio in the same animal was observed. Postinjury administration of TM-1 improved ALI and reduced PE at 8 and 24 h following TBI. The pulmonary-protective effect of TM-1 may be attributed to, at least in part, downregulation of AQP1 and AQP4 expression after TBI.

Original languageEnglish
Article number729831
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015

Fingerprint

Acute Lung Injury
Brain
Derivatives
Pulmonary Edema
Lung
Aquaporins
Aquaporin 1
Aquaporin 4
Weights and Measures
thaliporphine
Traumatic Brain Injury
Lung Injury
Intraperitoneal Injections
Rats
Animals
Down-Regulation
TM 1
Tissue
Messenger RNA
Water

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Thaliporphine derivative improves acute lung injury after traumatic brain injury. / Chen, Gunng Shinng; Huang, Kuo Feng; Huang, Chien Chu; Wang, Jia Yi.

In: BioMed Research International, Vol. 2015, 729831, 2015.

Research output: Contribution to journalArticle

Chen, Gunng Shinng ; Huang, Kuo Feng ; Huang, Chien Chu ; Wang, Jia Yi. / Thaliporphine derivative improves acute lung injury after traumatic brain injury. In: BioMed Research International. 2015 ; Vol. 2015.
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