Terpenoids from the fermented broths of coprinellus radians

Ming Shian Lee, Che Jen Hsiao, Yu Ming Ju, Yueh Hsiung Kuo, Ruo Kai Lin, Tzong Huei Lee

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1 Citation (Scopus)

Abstract

One new sesquiterpenoid, namely coprinol (1), along with guanacastanes J (2), E (3) and N (4), were isolated from the ethyl acetate extracts of the fermented broths of the fungal strain Coprinellus radians #1168. Their structures were elucidated on the basis of spectroscopic data analysis. The growth inhibitory activities against A549 of 1-4 were evaluated, and only 4 exhibited moderate growth inhibitory activity with a GI50 value of 18.2 μM compared with fluorouracil (GI50 = 3.6 μM). All the compounds were also subjected to antifungal assay against Candida albicans ATCC 18804, C. albicans SC-5314, Cryptococcus neoformans ATCC 13690 and Saccharomyces cerevisiae ATCC 2345; all showed mild antifungal activity with MIC values of 128.0 μg/mL for 1-3 and 64.0 μg/mL for 4 in comparison with amphotericin B (MIC = 0.25 μg/mL) and ketoconazole (MIC = 1.0 μg/mL).

Original languageEnglish
Pages (from-to)1229-1230
Number of pages2
JournalNatural Product Communications
Volume11
Issue number9
Publication statusPublished - 2016

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Keywords

  • Antifungal assay
  • Coprinellus radians
  • Coprinol
  • Cytotoxicity
  • Guanacastane

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Lee, M. S., Hsiao, C. J., Ju, Y. M., Kuo, Y. H., Lin, R. K., & Lee, T. H. (2016). Terpenoids from the fermented broths of coprinellus radians. Natural Product Communications, 11(9), 1229-1230.