Teratogenic and cytogenetic effects of hycanthone in mice and rabbits

S. M. Sieber, J. Whang‐Peng, R. H. Adamson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Hycanthone administered daily to pregnant mice at 3 dose levels on days 61–11 of gestation produced embryolethality and a depression of fetal body weights. At 12.5 mg/kg, no teratogenic effects were observed; at 25 mg/kg, fetal malforrnations occurred, and at 50 mg/kg, more than 90% of the conceptuses were killed. When hycanthone was administered to mice as single injections on days 5–9 of gestation embryolethal and teratogenic effects appeared to be limited to days 6 and 7. In rabbits hycanthone treatment on days 7, 8, and 9 of gestation produced embryolethality at a dose of 25 mg/kg and both embryolethality and teratogenicity at 50 mg/kg. Although hycanthone depressed the mitotic Index and induced chromosomal aberrations in microcultures of blood from untreated rabbits no cytogenetic effects of the drug were observed in either adult or fetal mice and rabbits in vivo.

Original languageEnglish
Pages (from-to)227-236
Number of pages10
JournalTeratology
Volume10
Issue number3
DOIs
Publication statusPublished - Jan 1 1974
Externally publishedYes

Fingerprint

Hycanthone
Cytogenetics
Rabbits
Pregnancy
Fetal Weight
Mitotic Index
Aberrations
Chromosome Aberrations
Blood
Injections
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Embryology
  • Toxicology
  • Developmental Biology
  • Health, Toxicology and Mutagenesis

Cite this

Teratogenic and cytogenetic effects of hycanthone in mice and rabbits. / Sieber, S. M.; Whang‐Peng, J.; Adamson, R. H.

In: Teratology, Vol. 10, No. 3, 01.01.1974, p. 227-236.

Research output: Contribution to journalArticle

Sieber, S. M. ; Whang‐Peng, J. ; Adamson, R. H. / Teratogenic and cytogenetic effects of hycanthone in mice and rabbits. In: Teratology. 1974 ; Vol. 10, No. 3. pp. 227-236.
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