Ten-year experience of children with tuberculosis in southern Taiwan

Bao Ren Nong, Chih Ming Chuang, Yung Feng Huang, Kai Sheng Hsieh, Yung Ching Liu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background and purpose: Data on the clinical characteristics of pediatric tuberculosis (TB) are limited. This retro-spective study was performed to evaluate the demographic characteristics and clinical features of pediatric TB. Methods: The medical records of children with TB at Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, between 1992 and 2002 were analyzed for demographic and clinical characteristics, and treatment regimens. Results: 103 children aged 0 to 14 years with probable or confirmed TB were enrolled. Ninety patients (87.4%) had pulmonary tuberculosis (PTB) and 13 (12.6%) had extrapulmonary tuberculosis (EPTB). The mean ± standard deviation age of children with PTB and with EPTB was 6.0 ± 4.2 years and 4.5 ± 5.4 years, respectively. Household contact was the route of infection for 44.4% of patients with PTB and 7.7% of patients with EPTB. TB in children aged 0 to 4 years most commonly involved the lung (53.3%) or the extrapulmonary region (69.2%). Common symptoms of PTB were cough (81.1%) and fever (33.3%). The most frequent sites of pediatric EPTB were bone (n = 4) and cervical lymph nodes (n = 4). Tuberculin skin test (TST; ≥10 mm) was positive in 69.6% of children with PTB (55/79) and 37.5% of children with EPTB (3/8). Children with PTB had a lower positive acid-fast bacilli rate (40.0%) and Mycobacterium tuberculosis culture (27.8%). Eighty percent of patients infected through household contact had a positive TST. Conclusion: Prolonged cough, household TB contact, and positive TST were characteristic factors for children with PTB in southern Taiwan. Young age was associated with high morbidity.

Original languageEnglish
Pages (from-to)516-520
Number of pages5
JournalJournal of Microbiology, Immunology and Infection
Volume42
Issue number6
Publication statusPublished - Dec 2009
Externally publishedYes

Fingerprint

Taiwan
Tuberculosis
Pulmonary Tuberculosis
Pediatrics
Cough
Demography
Osteoarticular Tuberculosis
Veterans Hospitals
Tuberculin Test
Skin Tests
Mycobacterium tuberculosis
General Hospitals
Bacillus
Medical Records
Fever
Lymph Nodes
Morbidity
Lung
Acids
Infection

Keywords

  • Tuberculosis
  • Tuberculosis pulmonary

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Infectious Diseases

Cite this

Ten-year experience of children with tuberculosis in southern Taiwan. / Nong, Bao Ren; Chuang, Chih Ming; Huang, Yung Feng; Hsieh, Kai Sheng; Liu, Yung Ching.

In: Journal of Microbiology, Immunology and Infection, Vol. 42, No. 6, 12.2009, p. 516-520.

Research output: Contribution to journalArticle

Nong, Bao Ren ; Chuang, Chih Ming ; Huang, Yung Feng ; Hsieh, Kai Sheng ; Liu, Yung Ching. / Ten-year experience of children with tuberculosis in southern Taiwan. In: Journal of Microbiology, Immunology and Infection. 2009 ; Vol. 42, No. 6. pp. 516-520.
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AB - Background and purpose: Data on the clinical characteristics of pediatric tuberculosis (TB) are limited. This retro-spective study was performed to evaluate the demographic characteristics and clinical features of pediatric TB. Methods: The medical records of children with TB at Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, between 1992 and 2002 were analyzed for demographic and clinical characteristics, and treatment regimens. Results: 103 children aged 0 to 14 years with probable or confirmed TB were enrolled. Ninety patients (87.4%) had pulmonary tuberculosis (PTB) and 13 (12.6%) had extrapulmonary tuberculosis (EPTB). The mean ± standard deviation age of children with PTB and with EPTB was 6.0 ± 4.2 years and 4.5 ± 5.4 years, respectively. Household contact was the route of infection for 44.4% of patients with PTB and 7.7% of patients with EPTB. TB in children aged 0 to 4 years most commonly involved the lung (53.3%) or the extrapulmonary region (69.2%). Common symptoms of PTB were cough (81.1%) and fever (33.3%). The most frequent sites of pediatric EPTB were bone (n = 4) and cervical lymph nodes (n = 4). Tuberculin skin test (TST; ≥10 mm) was positive in 69.6% of children with PTB (55/79) and 37.5% of children with EPTB (3/8). Children with PTB had a lower positive acid-fast bacilli rate (40.0%) and Mycobacterium tuberculosis culture (27.8%). Eighty percent of patients infected through household contact had a positive TST. Conclusion: Prolonged cough, household TB contact, and positive TST were characteristic factors for children with PTB in southern Taiwan. Young age was associated with high morbidity.

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