Temporal trends and molecular epidemiology of HIV-1 infection in Taiwan from 1988 to 1998

Yi Ming A. Chen, Kui Li Huang, Ian Jen, Shou Chien Chen, Yuan Chin Liu, Yin Chin Chuang, Jen Chien Wong, Jih Jin Tsai, Yu Chin Lan

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20 Citations (Scopus)

Abstract

Eight hundred and seventy-nine HIV-1-infected patients (comprising 46% of reported HIV-1/AIDS cases in Taiwan) were recruited for this study of the molecular epidemiology of HIV-1 in Taiwan from 1988 to 1998. HIV-1 subtypes were determined using a modified peptide-enzyme immunoassay complemented with DNA sequencing and phylogenetic analysis. Of the 807 HIV-1 infected men, 68.2% were infected with HIV-1B, 29.5% with HIV-1 circulating recombinant form (CRF)01_AE and 2.3% with other subtypes. Of the 72 HIV-1-infected women, 72.2% were infected with HIV-1 CRF01_AE, 13.9% with HIV-1B, and 13.9% with other subtypes. All of 8 foreign-born, Southeast Asian women and 6 of 7 (85.7%) Taiwan-native female commercial sex workers were infected with HIV-1 CRF01_AE. Fourteen of the 33 (42.4%) heterosexual married men with CRF01_AE had transmitted HIV-1 to their wives, whereas only 1 of 17 (5.9%) men with HIV-1 B had transmitted HIV-1 to their spouses (p < .01). Of 18 heterosexual male injecting drug users, 1 of 12 (8.5%) with HIV-1B and 5 of 6 (83.3%) with HIV-1 CRF01_AE had had sexual contact with female commercial sex workers (p < .01). Therefore, in this population, CRF01_AE was preferentially associated with heterosexual risk groups, a finding compatible with differences in transmission capability between B and non-B subtypes.

Original languageEnglish
Pages (from-to)274-282
Number of pages9
JournalJournal of Acquired Immune Deficiency Syndromes
Volume26
Issue number3
DOIs
Publication statusPublished - Mar 1 2001
Externally publishedYes

Keywords

  • Female sex workers
  • Heterosexual transmission
  • HIV-1 subtypes
  • Injecting drug users
  • Molecular epidemiology

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Chen, Y. M. A., Huang, K. L., Jen, I., Chen, S. C., Liu, Y. C., Chuang, Y. C., Wong, J. C., Tsai, J. J., & Lan, Y. C. (2001). Temporal trends and molecular epidemiology of HIV-1 infection in Taiwan from 1988 to 1998. Journal of Acquired Immune Deficiency Syndromes, 26(3), 274-282. https://doi.org/10.1097/00126334-200103010-00011