Temporal sequence of the bidirectional relationship between hyperglycemia and periodontal disease

a community-based study of 5,885 Taiwanese aged 35–44 years (KCIS No. 32)

Sherry Yueh Hsia Chiu, Hongmin Lai, Amy Ming Fang Yen, Jean Ching Yuan Fann, Li Sheng Chen, Hsiu Hsi Chen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The relationship between hyperglycemia (including diabetes) and periodontal disease (PD) has been noted previously, but its temporal sequence in the same study based on a population-based study has been barely addressed. Our study sought to clarify temporal bidirectional relationships between both diseases among Taiwanese aged 35–44 years. A prospective follow-up cohort study was designed by following over time the two normal cohorts (PD-free or hyperglycemia-free) derived from 5,885 subjects aged 35–44 years who were periodically attending a screening program. We ascertained both incident cases of PD (defined by Community Periodontal Index score ≧ 3) and hyperglycemia [fasting plasma glucose (FPG) ≧100 mg/dL] or type 2 diabetes (FPG ≧ 126 mg/dL) with 5-year follow-up. Cox proportional hazards regression model was used to assess the effect of PD on hyperglycemia and vice versa with adjustment for other confounding factors. Participants with PD presented a 33 % increase in their risk of incident hyperglycemia (including diabetes) [adjusted hazard ratio (aHR) = 1.33 (95 % CI 1.09–1.63)] after controlling for potential confounding factors. Conversely, prediabetes and type 2 diabetes mellitus led to a significant elevated risk for PD [aHR = 1.25 (95 % CI 1.00–1.57) and aHR = 1.95 (95 % CI 1.22–3.13)] after adjustment for other confounding factors. In conclusion, a significant bidirectional relationships was found between hyperglycemia and PD, suggesting that both diseases may share common latent traits and pathways that are worthy of being further elucidated by continuing a long-term follow-up of this cohort.

Original languageEnglish
Pages (from-to)123-131
Number of pages9
JournalActa Diabetologica
Volume52
Issue number1
DOIs
Publication statusPublished - 2015

Fingerprint

Periodontal Diseases
Hyperglycemia
Type 2 Diabetes Mellitus
Prediabetic State
Periodontal Index
Proportional Hazards Models
Fasting
Cohort Studies
Glucose
Population

Keywords

  • Bidirectional relationship
  • Hazard ratio
  • Hyperglycemia
  • Periodontal disease
  • Prediabetes

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Temporal sequence of the bidirectional relationship between hyperglycemia and periodontal disease : a community-based study of 5,885 Taiwanese aged 35–44 years (KCIS No. 32). / Chiu, Sherry Yueh Hsia; Lai, Hongmin; Yen, Amy Ming Fang; Fann, Jean Ching Yuan; Chen, Li Sheng; Chen, Hsiu Hsi.

In: Acta Diabetologica, Vol. 52, No. 1, 2015, p. 123-131.

Research output: Contribution to journalArticle

@article{85b096502118426dad1d5abb6580fb4b,
title = "Temporal sequence of the bidirectional relationship between hyperglycemia and periodontal disease: a community-based study of 5,885 Taiwanese aged 35–44 years (KCIS No. 32)",
abstract = "The relationship between hyperglycemia (including diabetes) and periodontal disease (PD) has been noted previously, but its temporal sequence in the same study based on a population-based study has been barely addressed. Our study sought to clarify temporal bidirectional relationships between both diseases among Taiwanese aged 35–44 years. A prospective follow-up cohort study was designed by following over time the two normal cohorts (PD-free or hyperglycemia-free) derived from 5,885 subjects aged 35–44 years who were periodically attending a screening program. We ascertained both incident cases of PD (defined by Community Periodontal Index score ≧ 3) and hyperglycemia [fasting plasma glucose (FPG) ≧100 mg/dL] or type 2 diabetes (FPG ≧ 126 mg/dL) with 5-year follow-up. Cox proportional hazards regression model was used to assess the effect of PD on hyperglycemia and vice versa with adjustment for other confounding factors. Participants with PD presented a 33 {\%} increase in their risk of incident hyperglycemia (including diabetes) [adjusted hazard ratio (aHR) = 1.33 (95 {\%} CI 1.09–1.63)] after controlling for potential confounding factors. Conversely, prediabetes and type 2 diabetes mellitus led to a significant elevated risk for PD [aHR = 1.25 (95 {\%} CI 1.00–1.57) and aHR = 1.95 (95 {\%} CI 1.22–3.13)] after adjustment for other confounding factors. In conclusion, a significant bidirectional relationships was found between hyperglycemia and PD, suggesting that both diseases may share common latent traits and pathways that are worthy of being further elucidated by continuing a long-term follow-up of this cohort.",
keywords = "Bidirectional relationship, Hazard ratio, Hyperglycemia, Periodontal disease, Prediabetes",
author = "Chiu, {Sherry Yueh Hsia} and Hongmin Lai and Yen, {Amy Ming Fang} and Fann, {Jean Ching Yuan} and Chen, {Li Sheng} and Chen, {Hsiu Hsi}",
year = "2015",
doi = "10.1007/s00592-014-0612-0",
language = "English",
volume = "52",
pages = "123--131",
journal = "Acta Diabetologica",
issn = "0940-5429",
publisher = "Springer-Verlag Italia",
number = "1",

}

TY - JOUR

T1 - Temporal sequence of the bidirectional relationship between hyperglycemia and periodontal disease

T2 - a community-based study of 5,885 Taiwanese aged 35–44 years (KCIS No. 32)

AU - Chiu, Sherry Yueh Hsia

AU - Lai, Hongmin

AU - Yen, Amy Ming Fang

AU - Fann, Jean Ching Yuan

AU - Chen, Li Sheng

AU - Chen, Hsiu Hsi

PY - 2015

Y1 - 2015

N2 - The relationship between hyperglycemia (including diabetes) and periodontal disease (PD) has been noted previously, but its temporal sequence in the same study based on a population-based study has been barely addressed. Our study sought to clarify temporal bidirectional relationships between both diseases among Taiwanese aged 35–44 years. A prospective follow-up cohort study was designed by following over time the two normal cohorts (PD-free or hyperglycemia-free) derived from 5,885 subjects aged 35–44 years who were periodically attending a screening program. We ascertained both incident cases of PD (defined by Community Periodontal Index score ≧ 3) and hyperglycemia [fasting plasma glucose (FPG) ≧100 mg/dL] or type 2 diabetes (FPG ≧ 126 mg/dL) with 5-year follow-up. Cox proportional hazards regression model was used to assess the effect of PD on hyperglycemia and vice versa with adjustment for other confounding factors. Participants with PD presented a 33 % increase in their risk of incident hyperglycemia (including diabetes) [adjusted hazard ratio (aHR) = 1.33 (95 % CI 1.09–1.63)] after controlling for potential confounding factors. Conversely, prediabetes and type 2 diabetes mellitus led to a significant elevated risk for PD [aHR = 1.25 (95 % CI 1.00–1.57) and aHR = 1.95 (95 % CI 1.22–3.13)] after adjustment for other confounding factors. In conclusion, a significant bidirectional relationships was found between hyperglycemia and PD, suggesting that both diseases may share common latent traits and pathways that are worthy of being further elucidated by continuing a long-term follow-up of this cohort.

AB - The relationship between hyperglycemia (including diabetes) and periodontal disease (PD) has been noted previously, but its temporal sequence in the same study based on a population-based study has been barely addressed. Our study sought to clarify temporal bidirectional relationships between both diseases among Taiwanese aged 35–44 years. A prospective follow-up cohort study was designed by following over time the two normal cohorts (PD-free or hyperglycemia-free) derived from 5,885 subjects aged 35–44 years who were periodically attending a screening program. We ascertained both incident cases of PD (defined by Community Periodontal Index score ≧ 3) and hyperglycemia [fasting plasma glucose (FPG) ≧100 mg/dL] or type 2 diabetes (FPG ≧ 126 mg/dL) with 5-year follow-up. Cox proportional hazards regression model was used to assess the effect of PD on hyperglycemia and vice versa with adjustment for other confounding factors. Participants with PD presented a 33 % increase in their risk of incident hyperglycemia (including diabetes) [adjusted hazard ratio (aHR) = 1.33 (95 % CI 1.09–1.63)] after controlling for potential confounding factors. Conversely, prediabetes and type 2 diabetes mellitus led to a significant elevated risk for PD [aHR = 1.25 (95 % CI 1.00–1.57) and aHR = 1.95 (95 % CI 1.22–3.13)] after adjustment for other confounding factors. In conclusion, a significant bidirectional relationships was found between hyperglycemia and PD, suggesting that both diseases may share common latent traits and pathways that are worthy of being further elucidated by continuing a long-term follow-up of this cohort.

KW - Bidirectional relationship

KW - Hazard ratio

KW - Hyperglycemia

KW - Periodontal disease

KW - Prediabetes

UR - http://www.scopus.com/inward/record.url?scp=84939889977&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939889977&partnerID=8YFLogxK

U2 - 10.1007/s00592-014-0612-0

DO - 10.1007/s00592-014-0612-0

M3 - Article

VL - 52

SP - 123

EP - 131

JO - Acta Diabetologica

JF - Acta Diabetologica

SN - 0940-5429

IS - 1

ER -