Telithromycin- and fluoroquinolone-resistant Streptococcus pneumoniae in Taiwan with high prevalence of resistance to macrolides and β-lactams: SMART program 2001 data

Po Ren Hsueh, Lee Jene Teng, Tsu Lan Wu, Dine Yang, Wen Kuei Huang, Jainn Ming Shyr, Yin Ching Chuang, Jen Hsien Wan, Jing Jou Yan, Jang Jih Lu, Jiunn Jong Wu, Wen Chien Ko, Feng Yee Chang, Yi Chueh Yang, Yeu Jun Lau, Yung Ching Liu, Chun Ming Lee, Hsieh Shong Leu, Cheng Yi Liu, Kwen Tay Luh

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Abstract

There is a high prevalence of β-lactam- and macrolide-resistant Streptococcus pneumoniae in Taiwan. To understand the in vitro susceptibilities of recent isolates of S. pneumoniae to fluoroquinolones and telithromycin (which is not available in Taiwan), the MICs of 23 antimicrobial agents for 936 clinical isolates of S. pneumoniae isolated from different parts of Taiwan from 2000 to 2001 were determined by the agar dilution method. Overall, 72% of isolates were not susceptible to penicillin (with 61% being intermediate and 11% being resistant) and 92% were resistant to erythromycin. Telithromycin MICs were ≥1 μg/ml for 16% of the isolates, and for 99% of these isolates the MICs of all macrolides tested were ≥256 μg/ml; all of these isolates had the constitutive macrolide-lincosamide-streptogramin B phenotype. Eighty-eight percent of the isolates were resistant to three or more classes of drugs. The ciprofloxacin MICs were ≥4 μg/ml for six (0.6%) isolates from five patients collected in 2000 and 2001, and the levofloxacin MICs were ≥8 μg/ml for five of these isolates. Seven isolates for which ciprofloxacin MICs were ≥4 μg/ml, including one isolate recovered in 1999, belonged to three serotypes (serotype 19F, five isolates; serotype 23A, one isolate; and serotype 23B, one isolate). The isolates from the six patients for which ciprofloxacin MICs were ≥4 μg/ml had different pulsed-field gel electrophoresis profiles and random amplified polymorphic DNA patterns, indicating that no clonal dissemination occurred over this time period. Despite the increased rate of fluoroquinolone use, the proportion of pneumococcal isolates for which ciprofloxacin MICs were elevated (≥4 μg/ml) remained low. However, the occurrence of telithromycin resistance is impressive and raises concerns for the future.

Original languageEnglish
Pages (from-to)2145-2151
Number of pages7
JournalAntimicrobial Agents and Chemotherapy
Volume47
Issue number7
DOIs
Publication statusPublished - Jul 1 2003
Externally publishedYes

Fingerprint

Lactams
Fluoroquinolones
Macrolides
Ciprofloxacin
Streptococcus pneumoniae
Taiwan
Streptogramin B
Lincosamides
Levofloxacin
Pulsed Field Gel Electrophoresis
Erythromycin
Anti-Infective Agents
Penicillins
Agar
Phenotype
Serogroup
telithromycin
DNA
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Telithromycin- and fluoroquinolone-resistant Streptococcus pneumoniae in Taiwan with high prevalence of resistance to macrolides and β-lactams : SMART program 2001 data. / Hsueh, Po Ren; Teng, Lee Jene; Wu, Tsu Lan; Yang, Dine; Huang, Wen Kuei; Shyr, Jainn Ming; Chuang, Yin Ching; Wan, Jen Hsien; Yan, Jing Jou; Lu, Jang Jih; Wu, Jiunn Jong; Ko, Wen Chien; Chang, Feng Yee; Yang, Yi Chueh; Lau, Yeu Jun; Liu, Yung Ching; Lee, Chun Ming; Leu, Hsieh Shong; Liu, Cheng Yi; Luh, Kwen Tay.

In: Antimicrobial Agents and Chemotherapy, Vol. 47, No. 7, 01.07.2003, p. 2145-2151.

Research output: Contribution to journalArticle

Hsueh, PR, Teng, LJ, Wu, TL, Yang, D, Huang, WK, Shyr, JM, Chuang, YC, Wan, JH, Yan, JJ, Lu, JJ, Wu, JJ, Ko, WC, Chang, FY, Yang, YC, Lau, YJ, Liu, YC, Lee, CM, Leu, HS, Liu, CY & Luh, KT 2003, 'Telithromycin- and fluoroquinolone-resistant Streptococcus pneumoniae in Taiwan with high prevalence of resistance to macrolides and β-lactams: SMART program 2001 data', Antimicrobial Agents and Chemotherapy, vol. 47, no. 7, pp. 2145-2151. https://doi.org/10.1128/AAC.47.7.2145-2151.2003
Hsueh, Po Ren ; Teng, Lee Jene ; Wu, Tsu Lan ; Yang, Dine ; Huang, Wen Kuei ; Shyr, Jainn Ming ; Chuang, Yin Ching ; Wan, Jen Hsien ; Yan, Jing Jou ; Lu, Jang Jih ; Wu, Jiunn Jong ; Ko, Wen Chien ; Chang, Feng Yee ; Yang, Yi Chueh ; Lau, Yeu Jun ; Liu, Yung Ching ; Lee, Chun Ming ; Leu, Hsieh Shong ; Liu, Cheng Yi ; Luh, Kwen Tay. / Telithromycin- and fluoroquinolone-resistant Streptococcus pneumoniae in Taiwan with high prevalence of resistance to macrolides and β-lactams : SMART program 2001 data. In: Antimicrobial Agents and Chemotherapy. 2003 ; Vol. 47, No. 7. pp. 2145-2151.
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T1 - Telithromycin- and fluoroquinolone-resistant Streptococcus pneumoniae in Taiwan with high prevalence of resistance to macrolides and β-lactams

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AU - Hsueh, Po Ren

AU - Teng, Lee Jene

AU - Wu, Tsu Lan

AU - Yang, Dine

AU - Huang, Wen Kuei

AU - Shyr, Jainn Ming

AU - Chuang, Yin Ching

AU - Wan, Jen Hsien

AU - Yan, Jing Jou

AU - Lu, Jang Jih

AU - Wu, Jiunn Jong

AU - Ko, Wen Chien

AU - Chang, Feng Yee

AU - Yang, Yi Chueh

AU - Lau, Yeu Jun

AU - Liu, Yung Ching

AU - Lee, Chun Ming

AU - Leu, Hsieh Shong

AU - Liu, Cheng Yi

AU - Luh, Kwen Tay

PY - 2003/7/1

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