Technetium-99m-HMPAO brain SPECT in neonates with hypoglycemic encephalopathy

Nan Tsing Chiu, Chao Ching Huang, Ying Chao Chang, Chyi Her Lin, Wei Jen Yao, Chin Yin Yu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Regional brain injury in three neonates with hypoglycemic encephalopathy are presented using serial 99mTc-hexamethyl propyleneamine oxime (HMPAO) SPECT and, for comparison, MRI. During the acute stage, both 99mTc-HMPAO SPECT and MRI reveal abnormalities in the posterior cerebrum. Technetium- 99m-HMPAO SPECT reveals further areas of insult, for example the frontal lobes. The degree of hypoperfusion correlates with the clinical severity of hypoglycemia during the neonatal period and subsequent neurological sequelae. Follow-up with HMPAO SPECT several months after insult demonstrates persistent hypoperfusion in some areas, mainly in the occipital and posterior parietal regions. MRI can depict morphological changes with superior resolution. Because morphological change generally follows slowly after functional change, MRI is less sensitive than HMPAO SPECT in detecting and predicting the extent of hypoglycemic cerebral injury during the acute phase. HMPAO SPECT during the acute stage is a valuable tool for evaluating the extent and severity of brain injury in neonates with hypoglycemic encephalopathy.

Original languageEnglish
Pages (from-to)1711-1713
Number of pages3
JournalJournal of Nuclear Medicine
Volume39
Issue number10
Publication statusPublished - Oct 1998
Externally publishedYes

Fingerprint

Oximes
Technetium
Brain Diseases
Single-Photon Emission-Computed Tomography
Hypoglycemic Agents
Brain
Brain Injuries
Parietal Lobe
Cerebrum
Frontal Lobe
Hypoglycemia
Magnetic Resonance Imaging
Wounds and Injuries

Keywords

  • HMPAO SPECT
  • Hypoglycemia
  • Neonate
  • Seizure

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Chiu, N. T., Huang, C. C., Chang, Y. C., Lin, C. H., Yao, W. J., & Yu, C. Y. (1998). Technetium-99m-HMPAO brain SPECT in neonates with hypoglycemic encephalopathy. Journal of Nuclear Medicine, 39(10), 1711-1713.

Technetium-99m-HMPAO brain SPECT in neonates with hypoglycemic encephalopathy. / Chiu, Nan Tsing; Huang, Chao Ching; Chang, Ying Chao; Lin, Chyi Her; Yao, Wei Jen; Yu, Chin Yin.

In: Journal of Nuclear Medicine, Vol. 39, No. 10, 10.1998, p. 1711-1713.

Research output: Contribution to journalArticle

Chiu, NT, Huang, CC, Chang, YC, Lin, CH, Yao, WJ & Yu, CY 1998, 'Technetium-99m-HMPAO brain SPECT in neonates with hypoglycemic encephalopathy', Journal of Nuclear Medicine, vol. 39, no. 10, pp. 1711-1713.
Chiu, Nan Tsing ; Huang, Chao Ching ; Chang, Ying Chao ; Lin, Chyi Her ; Yao, Wei Jen ; Yu, Chin Yin. / Technetium-99m-HMPAO brain SPECT in neonates with hypoglycemic encephalopathy. In: Journal of Nuclear Medicine. 1998 ; Vol. 39, No. 10. pp. 1711-1713.
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