TDP-43 Regulates Coupled Dendritic mRNA Transport-Translation Processes in Co-operation with FMRP and Staufen1

Jen Fei Chu, Pritha Majumder, Biswanath Chatterjee, Shih Ling Huang, Che Kun James Shen

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Chu et al. explore mechanisms of TDP-43-mediated dendritic mRNA transport, combining molecular approaches, real-time imaging, and an RNA biosensor. Analysis of the kinetics and dynamics of coupled transport-translation processes of Rac1 mRNA in neuronal dendrites demonstrates that TDP-43 regulates these processes in cooperation with FMRP and Staufen1 in different subcompartments.

Original languageEnglish
Pages (from-to)3118-3133.e6
JournalCell Reports
Volume29
Issue number10
DOIs
Publication statusPublished - Dec 3 2019
Externally publishedYes

Keywords

  • fluorescence tagging by genome editing
  • FMRP
  • hippocampal neuron dendrites
  • Kinesin1
  • live-cell imaging
  • RNA FISH
  • RNA granule transport-translation
  • TDP-43
  • TRICK reporter RNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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