TDP-43: an emerging new player in neurodegenerative diseases

I. Fan Wang, Lien Szu Wu, C. K.James Shen

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Until a couple of years ago, TAR-DNA-binding protein-43 (TDP-43) was a relatively unknown nuclear protein implicated in transcriptional repression and splicing. Since 2006, when the protein was reported to be present in inclusions in the neurons and/or glial cells of a range of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with ubiquitin-positive, tau- and α-synuclein-negative inclusions (FTLD-U) and Alzheimer's disease (AD), many reports on the medical aspects of TDP-43 have been published. Here, we summarize the current literature on TDP-43, focusing on recent studies that provide clues to the function of TDP-43. Using this information and database analysis, we also suggest a molecular and cellular model for possible events in normal and diseased neurons in relation to the emerging importance of the function and dysfunction of this protein as a target for basic as well as translational research.

Original languageEnglish
Pages (from-to)479-485
Number of pages7
JournalTrends in Molecular Medicine
Volume14
Issue number11
DOIs
Publication statusPublished - Nov 1 2008
Externally publishedYes

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DNA-Binding Proteins
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Synucleins
Neurons
Molecular Models
Translational Medical Research
Amyotrophic Lateral Sclerosis
Nuclear Proteins
Ubiquitin
Neuroglia
Alzheimer Disease
Proteins
Databases

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

TDP-43 : an emerging new player in neurodegenerative diseases. / Wang, I. Fan; Wu, Lien Szu; Shen, C. K.James.

In: Trends in Molecular Medicine, Vol. 14, No. 11, 01.11.2008, p. 479-485.

Research output: Contribution to journalArticle

Wang, I. Fan ; Wu, Lien Szu ; Shen, C. K.James. / TDP-43 : an emerging new player in neurodegenerative diseases. In: Trends in Molecular Medicine. 2008 ; Vol. 14, No. 11. pp. 479-485.
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