Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin b

Tsui Chin Huang, Hsin Yi Chang, Chun Hua Hsu, Wen Hung Kuo, King Jen Chang, Hsueh Fen Juan

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Targeting of tumor tissues is one of the most powerful approaches to accelerate the efficiency of anticancer treatments. The investigation of effective targets, including proteins specifically and abundantly expressed in abnormal regions, has been one of the most important research topics in cancer therapy. In this study, we performed a proteomic analysis on human breast carcinoma tissues to investigate the tumor-specific protein expression in breast carcinoma. Our study showed that ATP synthase was up-regulated in tumor tissues and was present on the plasma membrane of breast cancer cells. Furthermore, we treated the breast cancer cells with ATP synthase inhibitors and examined the inhibitory efficiency. Aurovertin B, an ATP synthase inhibitor, has strong inhibition on the proliferation of several breast cancer cell lines, but little influence on the normal cell line MCF-10A. Aurovertin B inhibits proliferation of breast cancer cells by inducing apoptosis and arresting cell cycle at the G0/G1 phase. This study showed aurovertin B can be used as an antitumorigenic agent and may be exploited in cancer chemotherapy.

Original languageEnglish
Pages (from-to)1433-1444
Number of pages12
JournalJournal of Proteome Research
Volume7
Issue number4
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Aurovertins
Adenosine Triphosphate
Cells
Breast Neoplasms
Tumors
Neoplasms
Tissue
Therapeutics
Cell Line
Cell Cycle Resting Phase
Chemotherapy
G1 Phase
Cell membranes
Proteomics
Cell Cycle
Proteins
Cell Membrane
Apoptosis
Drug Therapy

Keywords

  • Apoptosis
  • ATP synthase
  • Aurovertin B
  • Breast carcinoma
  • Cell cycle arrest
  • Proteomic analysis
  • Targeting therapy

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Genetics
  • Biotechnology

Cite this

Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin b. / Huang, Tsui Chin; Chang, Hsin Yi; Hsu, Chun Hua; Kuo, Wen Hung; Chang, King Jen; Juan, Hsueh Fen.

In: Journal of Proteome Research, Vol. 7, No. 4, 04.2008, p. 1433-1444.

Research output: Contribution to journalArticle

Huang, Tsui Chin ; Chang, Hsin Yi ; Hsu, Chun Hua ; Kuo, Wen Hung ; Chang, King Jen ; Juan, Hsueh Fen. / Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin b. In: Journal of Proteome Research. 2008 ; Vol. 7, No. 4. pp. 1433-1444.
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AU - Juan, Hsueh Fen

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