Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin b

Tsui Chin Huang, Hsin Yi Chang, Chun Hua Hsu, Wen Hung Kuo, King Jen Chang, Hsueh Fen Juan

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Targeting of tumor tissues is one of the most powerful approaches to accelerate the efficiency of anticancer treatments. The investigation of effective targets, including proteins specifically and abundantly expressed in abnormal regions, has been one of the most important research topics in cancer therapy. In this study, we performed a proteomic analysis on human breast carcinoma tissues to investigate the tumor-specific protein expression in breast carcinoma. Our study showed that ATP synthase was up-regulated in tumor tissues and was present on the plasma membrane of breast cancer cells. Furthermore, we treated the breast cancer cells with ATP synthase inhibitors and examined the inhibitory efficiency. Aurovertin B, an ATP synthase inhibitor, has strong inhibition on the proliferation of several breast cancer cell lines, but little influence on the normal cell line MCF-10A. Aurovertin B inhibits proliferation of breast cancer cells by inducing apoptosis and arresting cell cycle at the G0/G1 phase. This study showed aurovertin B can be used as an antitumorigenic agent and may be exploited in cancer chemotherapy.

Original languageEnglish
Pages (from-to)1433-1444
Number of pages12
JournalJournal of Proteome Research
Volume7
Issue number4
DOIs
Publication statusPublished - Apr 2008

Keywords

  • Apoptosis
  • ATP synthase
  • Aurovertin B
  • Breast carcinoma
  • Cell cycle arrest
  • Proteomic analysis
  • Targeting therapy

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Genetics
  • Biotechnology

Fingerprint Dive into the research topics of 'Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin b'. Together they form a unique fingerprint.

  • Cite this