Targeting myotonic dystrophy by preimplantation genetic diagnosis-karyomapping

Research output: Contribution to journalArticle

Abstract

Objective: To report a case with Myotonic dystrophy type I with successful preimplantation genetic diagnosis-karyomapping. Case report: A 34-year-old female carrier of myotonic dystrophy type I was treated at our clinic with a successful pregnancy after preimplantation genetic testing for monogenic disorders using karyomapping of her blastocysts. Conclusion: Myotonic dystrophy type I is an inherited autosomal dominant disease producing various neuromuscular disturbances. Offspring of carriers have a 50% chance of carrying CTG repeat sequences in the DMPK gene, and various time-consuming methodologies have been developed for genetic diagnosis. With a novel, efficient, and precise method by karyomapping using single nucleotide polymorphism arrays to diagnose single gene disorders, one could terminate the transmission of single gene disorder. Herein, we reported a 34-year-old female carrier of myotonic dystrophy type I achieve a successful pregnancy after preimplantation genetic testing for monogenic disorders using karyomapping method of her blastocysts.

Original languageEnglish
JournalTaiwanese Journal of Obstetrics and Gynecology
DOIs
Publication statusAccepted/In press - Jan 1 2019

Keywords

  • Karyomapping
  • Myotonic dystrophy
  • Preimplantation genetic testing

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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