Targeting c-Myc as a novel approach for hepatocellular carcinoma

Che Pin Lin, Chien Ru Liu, Chun Nin Lee, Tze Sian Chan, H. Eugene Liu

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Hepatocelluar carcinoma (HCC) is the most lethal cancer in the world. Most HCC over-express c-Myc, which plays a critical role in regulating cellular growth, differentiation and apoptosis in both normal and neoplastic cells. c-Myc is among the most frequently overexpressed genes in human cancers. Overexpression of c-Myc in hepatic cells leads to development of hepatocellular carcinoma. Here, we review the current progress in understanding physiologic function and regulation of c-Myc as well as its role in hepatic carcinogenesis and discuss the association of c-Myc activation in chronic hepatitis B infection and the upregulation of HIF-1/ VEGF. We also explore the possibility of treating HCC by inhibiting c-Myc and examine the pros and cons of such an approach. Although this strategy is currently not available in clinics, with recent advances in better drug design, pharmacokinetics and pharmacogenetics,inhibition of c-Myc might become a novel therapy for HCC in the future.

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalWorld Journal of Hepatology
Volume2
Issue number1
DOIs
Publication statusPublished - 2010

Fingerprint

Hepatocellular Carcinoma
Carcinoma
Drug Design
Pharmacogenetics
Chronic Hepatitis B
Vascular Endothelial Growth Factor A
Hepatocytes
Neoplasms
Carcinogenesis
Up-Regulation
Pharmacokinetics
Apoptosis
Liver
Growth
Infection
Genes
Therapeutics

Keywords

  • C-Myc
  • Hepatocellular carcinoma
  • Novel therapy

ASJC Scopus subject areas

  • Hepatology

Cite this

Targeting c-Myc as a novel approach for hepatocellular carcinoma. / Lin, Che Pin; Liu, Chien Ru; Lee, Chun Nin; Chan, Tze Sian; Liu, H. Eugene.

In: World Journal of Hepatology, Vol. 2, No. 1, 2010, p. 16-20.

Research output: Contribution to journalArticle

Lin, Che Pin ; Liu, Chien Ru ; Lee, Chun Nin ; Chan, Tze Sian ; Liu, H. Eugene. / Targeting c-Myc as a novel approach for hepatocellular carcinoma. In: World Journal of Hepatology. 2010 ; Vol. 2, No. 1. pp. 16-20.
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