Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac

Thangirala Sudha, Dhruba J. Bharali, Murat Yalcin, Noureldien H E Darwish, Melis Debreli Coskun, Kelly A. Keating, Hung Yun Lin, Paul J. Davis, Shaker A. Mousa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The tetraiodothyroacetic acid (tetrac) component of nano-diamino-tetrac (NDAT) is chemically bonded via a linker to a poly(lactic-co-glycolic acid) nanoparticle that can encapsulate anticancer drugs. Tetrac targets the plasma membrane of cancer cells at a receptor on the extracellular domain of integrin αvβ3. In this study, we evaluate the efficiency of NDAT delivery of paclitaxel and doxorubicin to, respectively, pancreatic and breast cancer orthotopic nude mouse xenografts. Intra-tumoral drug concentrations were 5-fold (paclitaxel; P<0.001) and 2.3-fold (doxorubicin; P<0.01) higher than with conventional systemic drug administration. Tumor volume reductions reflected enhanced xenograft drug uptake. Cell viability was estimated by bioluminescent signaling in pancreatic tumors and confirmed an increased paclitaxel effect with drug delivery by NDAT. NDAT delivery of chemotherapy increases drug delivery to cancers and increases drug efficacy.

Original languageEnglish
Pages (from-to)1305-1315
Number of pages11
JournalInternational Journal of Nanomedicine
Volume12
DOIs
Publication statusPublished - Feb 15 2017

Fingerprint

Paclitaxel
Heterografts
Nanoparticles
Doxorubicin
Drug delivery
Acids
Tumors
Cells
Pharmaceutical Preparations
Neoplasms
Chemotherapy
Cell membranes
Integrins
tetraiodothyroacetic acid
Tumor Burden
Pancreatic Neoplasms
Nude Mice
Cell Survival
Cell Membrane
Breast Neoplasms

Keywords

  • Doxorubicin
  • Integrin
  • Nanoparticle
  • Nanotetrac
  • NDAT
  • Paclitaxel
  • Tetraiodothyroacetic acid
  • Xenografts

ASJC Scopus subject areas

  • Bioengineering
  • Biophysics
  • Biomaterials
  • Drug Discovery
  • Organic Chemistry

Cite this

Sudha, T., Bharali, D. J., Yalcin, M., Darwish, N. H. E., Coskun, M. D., Keating, K. A., ... Mousa, S. A. (2017). Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac. International Journal of Nanomedicine, 12, 1305-1315. https://doi.org/10.2147/IJN.S123742

Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac. / Sudha, Thangirala; Bharali, Dhruba J.; Yalcin, Murat; Darwish, Noureldien H E; Coskun, Melis Debreli; Keating, Kelly A.; Lin, Hung Yun; Davis, Paul J.; Mousa, Shaker A.

In: International Journal of Nanomedicine, Vol. 12, 15.02.2017, p. 1305-1315.

Research output: Contribution to journalArticle

Sudha, T, Bharali, DJ, Yalcin, M, Darwish, NHE, Coskun, MD, Keating, KA, Lin, HY, Davis, PJ & Mousa, SA 2017, 'Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac', International Journal of Nanomedicine, vol. 12, pp. 1305-1315. https://doi.org/10.2147/IJN.S123742
Sudha, Thangirala ; Bharali, Dhruba J. ; Yalcin, Murat ; Darwish, Noureldien H E ; Coskun, Melis Debreli ; Keating, Kelly A. ; Lin, Hung Yun ; Davis, Paul J. ; Mousa, Shaker A. / Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac. In: International Journal of Nanomedicine. 2017 ; Vol. 12. pp. 1305-1315.
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