TARC/CCL17 gene polymorphisms and expression associated with susceptibility and coronary artery aneurysm formation in Kawasaki disease

Chiu Ping Lee, Ying Hsien Huang, Yu Wen Hsu, Kuender D. Yang, Shu-Chen Chien, Hong Ren Yu, Ya Ling Yang, Chih Lu Wang, Wei Chiao Chang, Ho Chang Kuo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background:Kawasaki disease (KD) is a systemic vasculitis of unknown etiology. Thymus and activation-regulated chemokine/chemokine ligand 17 (TARC/CCL17) is one of the Th2 chemokines and has been suggested as a candidate gene for conferring susceptibility to Th2 associated with allergy diseases. This study examined the correlation between gene polymorphisms and plasma levels of TARC/CCL17 in patients with KD and the outcomes of KD.Methods:A total of 381 KD patients and 564 controls were subjected to determination of five tagging single-nucleotide polymorphisms of TARC/CCL17. In addition, plasma TARC/CCL17 levels were measured by enzyme-linked immunosorbent assay.Results:Polymorphisms of TARC/CCL17 were significantly different between normal children and patients with KD. A allele of rs4784805 has better intravenous immunoglobulin (IVIG) treatment response to KD. Furthermore, plasma TARC/CCL17 levels were higher in KD patients than that in controls before IVIG treatment. After IVIG treatment, plasma TARC/CCL17 levels decreased significantly.Conclusion:This study provides the first evidence supporting the association between TARC/CCL17 polymorphisms, susceptibility of KD, and IVIG responses in KD patients.

Original languageEnglish
Pages (from-to)545-551
Number of pages7
JournalPediatric Research
Volume74
Issue number5
DOIs
Publication statusPublished - Nov 2013

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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