Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells

Tso Hsiao Chen; Yu Tern Hsu; Cheng Hsien Chen; Shu Hwei Kao; Horng M. Lee

doi:10.1016/j.mito.2006.11.018

Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells

Tso Hsiao Chen, Yu Tern Hsu, Cheng Hsien Chen, Shu Hwei Kao, Horng M. Lee

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Tanshinone IIA exerts anti-inflammatory effects and influences electron transfer reaction in mitochondria. In the present study, we demonstrated that tanshinone IIA increased intracellular production of reactive oxygen species (ROS), which in turn induces heme oxygenase-1 (HO-1) expression in RAW 264.7 macrophages. Tanshinone IIA inhibited COX-2 and iNOS expression in lipopolysaccharide-activated RAW 264.7 macrophages. Inhibition of HO-1 or scavenging of CO significantly reversed the inhibition of LPS-stimulated nitrite accumulation by tanshinone IIA, suggesting a novel role of HO-1 in the anti-inflammatory effect of tanshinone IIA.

Original language	English
Pages (from-to)	101-105
Number of pages	5
Journal	Mitochondrion
Volume	7
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mito.2006.11.018
Publication status	Published - Feb 2007

Keywords

Cyclooxygenase-2
Heme oxygenase-1
RAW 264.7 macrophages
Tanshinone IIA

ASJC Scopus subject areas

Biophysics

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10.1016/j.mito.2006.11.018

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title = "Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells",

abstract = "Tanshinone IIA exerts anti-inflammatory effects and influences electron transfer reaction in mitochondria. In the present study, we demonstrated that tanshinone IIA increased intracellular production of reactive oxygen species (ROS), which in turn induces heme oxygenase-1 (HO-1) expression in RAW 264.7 macrophages. Tanshinone IIA inhibited COX-2 and iNOS expression in lipopolysaccharide-activated RAW 264.7 macrophages. Inhibition of HO-1 or scavenging of CO significantly reversed the inhibition of LPS-stimulated nitrite accumulation by tanshinone IIA, suggesting a novel role of HO-1 in the anti-inflammatory effect of tanshinone IIA.",

keywords = "Cyclooxygenase-2, Heme oxygenase-1, RAW 264.7 macrophages, Tanshinone IIA",

author = "Chen, {Tso Hsiao} and Hsu, {Yu Tern} and Chen, {Cheng Hsien} and Kao, {Shu Hwei} and Lee, {Horng M.}",

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AU - Chen, Tso Hsiao

AU - Hsu, Yu Tern

AU - Chen, Cheng Hsien

AU - Kao, Shu Hwei

AU - Lee, Horng M.

PY - 2007/2

Y1 - 2007/2

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KW - Heme oxygenase-1

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KW - Tanshinone IIA

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Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells

Abstract

Keywords

ASJC Scopus subject areas

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