Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells

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Abstract

Tanshinone IIA exerts anti-inflammatory effects and influences electron transfer reaction in mitochondria. In the present study, we demonstrated that tanshinone IIA increased intracellular production of reactive oxygen species (ROS), which in turn induces heme oxygenase-1 (HO-1) expression in RAW 264.7 macrophages. Tanshinone IIA inhibited COX-2 and iNOS expression in lipopolysaccharide-activated RAW 264.7 macrophages. Inhibition of HO-1 or scavenging of CO significantly reversed the inhibition of LPS-stimulated nitrite accumulation by tanshinone IIA, suggesting a novel role of HO-1 in the anti-inflammatory effect of tanshinone IIA.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalMitochondrion
Volume7
Issue number1-2
DOIs
Publication statusPublished - Feb 2007

Fingerprint

Salvia miltiorrhiza
Heme Oxygenase-1
Lipopolysaccharides
Nitric Oxide
Anti-Inflammatory Agents
Macrophages
Carbon Monoxide
Nitrites
Reactive Oxygen Species
Mitochondria
RAW 264.7 Cells
tanshinone
Electrons

Keywords

  • Cyclooxygenase-2
  • Heme oxygenase-1
  • RAW 264.7 macrophages
  • Tanshinone IIA

ASJC Scopus subject areas

  • Biophysics

Cite this

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title = "Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells",
abstract = "Tanshinone IIA exerts anti-inflammatory effects and influences electron transfer reaction in mitochondria. In the present study, we demonstrated that tanshinone IIA increased intracellular production of reactive oxygen species (ROS), which in turn induces heme oxygenase-1 (HO-1) expression in RAW 264.7 macrophages. Tanshinone IIA inhibited COX-2 and iNOS expression in lipopolysaccharide-activated RAW 264.7 macrophages. Inhibition of HO-1 or scavenging of CO significantly reversed the inhibition of LPS-stimulated nitrite accumulation by tanshinone IIA, suggesting a novel role of HO-1 in the anti-inflammatory effect of tanshinone IIA.",
keywords = "Cyclooxygenase-2, Heme oxygenase-1, RAW 264.7 macrophages, Tanshinone IIA",
author = "Chen, {Tso Hsiao} and Hsu, {Yu Tern} and Chen, {Cheng Hsien} and Kao, {Shu Hwei} and Lee, {Horng M.}",
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T1 - Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells

AU - Chen, Tso Hsiao

AU - Hsu, Yu Tern

AU - Chen, Cheng Hsien

AU - Kao, Shu Hwei

AU - Lee, Horng M.

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AB - Tanshinone IIA exerts anti-inflammatory effects and influences electron transfer reaction in mitochondria. In the present study, we demonstrated that tanshinone IIA increased intracellular production of reactive oxygen species (ROS), which in turn induces heme oxygenase-1 (HO-1) expression in RAW 264.7 macrophages. Tanshinone IIA inhibited COX-2 and iNOS expression in lipopolysaccharide-activated RAW 264.7 macrophages. Inhibition of HO-1 or scavenging of CO significantly reversed the inhibition of LPS-stimulated nitrite accumulation by tanshinone IIA, suggesting a novel role of HO-1 in the anti-inflammatory effect of tanshinone IIA.

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