Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells

Tso Hsiao Chen, Yu Tern Hsu, Cheng Hsien Chen, Shu Hwei Kao, Horng M. Lee

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Tanshinone IIA exerts anti-inflammatory effects and influences electron transfer reaction in mitochondria. In the present study, we demonstrated that tanshinone IIA increased intracellular production of reactive oxygen species (ROS), which in turn induces heme oxygenase-1 (HO-1) expression in RAW 264.7 macrophages. Tanshinone IIA inhibited COX-2 and iNOS expression in lipopolysaccharide-activated RAW 264.7 macrophages. Inhibition of HO-1 or scavenging of CO significantly reversed the inhibition of LPS-stimulated nitrite accumulation by tanshinone IIA, suggesting a novel role of HO-1 in the anti-inflammatory effect of tanshinone IIA.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalMitochondrion
Volume7
Issue number1-2
DOIs
Publication statusPublished - Feb 2007

    Fingerprint

Keywords

  • Cyclooxygenase-2
  • Heme oxygenase-1
  • RAW 264.7 macrophages
  • Tanshinone IIA

ASJC Scopus subject areas

  • Biophysics

Cite this