Tannic acid suppresses ultraviolet B-induced inflammatory signaling and complement factor B on human retinal pigment epithelial cells

Wen Wen Chou, Yung Song Wang, Ku Chung Chen, Jing Mei Wu, Chung Ling Liang, Suh Hang Hank Juo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Ultraviolet B (UVB) radiation may cause the inflammation of retinal pigment epithelium (RPE) cells and play a role in development of age-related macular degeneration (AMD). The activation of the complement factor B (CFB) gene has been shown to be involved in formation of AMD. Here our results revealed that UVB induces IL-6/STAT3 signaling activation and the UVB-induced STAT3 is able to regulate the CFB expression in ARPE-19 cells. Tannic acid (TA) is a kind of water-soluble polyphenol and may have anti-inflammation effects. We also found that TA attenuates the UVB-induced IL-6 protein production, the STAT3 phosphorylation and the CFB expression. Taken together, these findings suggest UVB-induced inflammation of RPE can be mediated through the IL-6/STAT3/CFB pathway, and TA has a protected effect via the inhibition to the inflammatory response.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalCellular Immunology
Volume273
Issue number1
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Complement Factor B
Retinal Pigments
Tannins
Epithelial Cells
Interleukin-6
Retinal Pigment Epithelium
Macular Degeneration
Inflammation
STAT3 Transcription Factor
Polyphenols
Phosphorylation
Radiation
Water
Genes

Keywords

  • Complement factor B
  • Inflammation
  • Interleukin-6
  • RPE
  • Ultraviolet

ASJC Scopus subject areas

  • Immunology

Cite this

Tannic acid suppresses ultraviolet B-induced inflammatory signaling and complement factor B on human retinal pigment epithelial cells. / Chou, Wen Wen; Wang, Yung Song; Chen, Ku Chung; Wu, Jing Mei; Liang, Chung Ling; Juo, Suh Hang Hank.

In: Cellular Immunology, Vol. 273, No. 1, 2012, p. 79-84.

Research output: Contribution to journalArticle

Chou, Wen Wen ; Wang, Yung Song ; Chen, Ku Chung ; Wu, Jing Mei ; Liang, Chung Ling ; Juo, Suh Hang Hank. / Tannic acid suppresses ultraviolet B-induced inflammatory signaling and complement factor B on human retinal pigment epithelial cells. In: Cellular Immunology. 2012 ; Vol. 273, No. 1. pp. 79-84.
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