Taiwanin E inhibits cell migration in human LoVo colon cancer cells by suppressing MMP-2/9 expression via p38 MAPK pathway

Hsi Hsien Hsu, Wei Wen Kuo, Cecilia Hsuan Day, Marthandam Asokan Shibu, Shin Yi Li, Sheng Huang Chang, Hui Nung Shih, Ray Jade Chen, Vijaya Padma Viswanadha, Yueh Hsiung Kuo, Chih Yang Huang

Research output: Contribution to journalArticle

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Abstract

Taiwanin E is a natural compound which is structurally analogous to estrogen II and is abundantly found in Taiwania cryptomerioides. It has been previously reported for its anticancer effects; however, the pharmaceutical effect of Taiwanin E on Human LoVo colon cancer cells is not clear. In this study, we investigated the effects of Taiwanin E on metastasis and the associated mechanism of action on Human LoVo colon cancer cells with respect to the modulations in their cell migration and signaling pathways associated with migration. The results showed that Taiwanin E inhibited cell migration ability correlated with reduced expression and activity of MMP-2 and MMP-9. In addition, Taiwanin E induced activation of p38 through phosphorylation. Inhibition of p38α/β significantly abolished the effect of Taiwanin E on cell migration and MMP-2/-9 activity. Our results conclude that Taiwanin E inhibited cell migration chiefly via p38α MAPK pathway and in a lesser extend via p38β MAPK. The results elucidate the potential of the phytoestrogen natural compound Taiwanin E as a cancer therapeutic agent in inhibiting the cell migration.

Original languageEnglish
JournalEnvironmental Toxicology
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

p38 Mitogen-Activated Protein Kinases
Matrix Metalloproteinases
Colonic Neoplasms
Cell Movement
cancer
Cells
Phytoestrogens
Phosphorylation
taiwanin E
drug
Estrogens
effect
Chemical activation
Modulation
Neoplasm Metastasis
Pharmaceutical Preparations

Keywords

  • Cell migration
  • Colon cancer
  • Matrix metalloproteinases
  • P38 MAPK
  • Taiwania cryptomerioides Hayata

ASJC Scopus subject areas

  • Toxicology
  • Management, Monitoring, Policy and Law
  • Health, Toxicology and Mutagenesis

Cite this

Taiwanin E inhibits cell migration in human LoVo colon cancer cells by suppressing MMP-2/9 expression via p38 MAPK pathway. / Hsu, Hsi Hsien; Kuo, Wei Wen; Day, Cecilia Hsuan; Shibu, Marthandam Asokan; Li, Shin Yi; Chang, Sheng Huang; Shih, Hui Nung; Chen, Ray Jade; Viswanadha, Vijaya Padma; Kuo, Yueh Hsiung; Huang, Chih Yang.

In: Environmental Toxicology, 2016.

Research output: Contribution to journalArticle

Hsu, Hsi Hsien ; Kuo, Wei Wen ; Day, Cecilia Hsuan ; Shibu, Marthandam Asokan ; Li, Shin Yi ; Chang, Sheng Huang ; Shih, Hui Nung ; Chen, Ray Jade ; Viswanadha, Vijaya Padma ; Kuo, Yueh Hsiung ; Huang, Chih Yang. / Taiwanin E inhibits cell migration in human LoVo colon cancer cells by suppressing MMP-2/9 expression via p38 MAPK pathway. In: Environmental Toxicology. 2016.
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abstract = "Taiwanin E is a natural compound which is structurally analogous to estrogen II and is abundantly found in Taiwania cryptomerioides. It has been previously reported for its anticancer effects; however, the pharmaceutical effect of Taiwanin E on Human LoVo colon cancer cells is not clear. In this study, we investigated the effects of Taiwanin E on metastasis and the associated mechanism of action on Human LoVo colon cancer cells with respect to the modulations in their cell migration and signaling pathways associated with migration. The results showed that Taiwanin E inhibited cell migration ability correlated with reduced expression and activity of MMP-2 and MMP-9. In addition, Taiwanin E induced activation of p38 through phosphorylation. Inhibition of p38α/β significantly abolished the effect of Taiwanin E on cell migration and MMP-2/-9 activity. Our results conclude that Taiwanin E inhibited cell migration chiefly via p38α MAPK pathway and in a lesser extend via p38β MAPK. The results elucidate the potential of the phytoestrogen natural compound Taiwanin E as a cancer therapeutic agent in inhibiting the cell migration.",
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AU - Shibu, Marthandam Asokan

AU - Li, Shin Yi

AU - Chang, Sheng Huang

AU - Shih, Hui Nung

AU - Chen, Ray Jade

AU - Viswanadha, Vijaya Padma

AU - Kuo, Yueh Hsiung

AU - Huang, Chih Yang

PY - 2016

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AB - Taiwanin E is a natural compound which is structurally analogous to estrogen II and is abundantly found in Taiwania cryptomerioides. It has been previously reported for its anticancer effects; however, the pharmaceutical effect of Taiwanin E on Human LoVo colon cancer cells is not clear. In this study, we investigated the effects of Taiwanin E on metastasis and the associated mechanism of action on Human LoVo colon cancer cells with respect to the modulations in their cell migration and signaling pathways associated with migration. The results showed that Taiwanin E inhibited cell migration ability correlated with reduced expression and activity of MMP-2 and MMP-9. In addition, Taiwanin E induced activation of p38 through phosphorylation. Inhibition of p38α/β significantly abolished the effect of Taiwanin E on cell migration and MMP-2/-9 activity. Our results conclude that Taiwanin E inhibited cell migration chiefly via p38α MAPK pathway and in a lesser extend via p38β MAPK. The results elucidate the potential of the phytoestrogen natural compound Taiwanin E as a cancer therapeutic agent in inhibiting the cell migration.

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