T-cell lymphoblastic lymphoma with eosinophilia associated with subsequent myeloid malignancy

L. V. Abruzzo, E. S. Jaffe, J. D. Cotelingam, J. Whang-Peng, V. Del Duca, L. J. Medeiros

Research output: Contribution to journalArticle

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Abstract

Three patients with T-cell lymphoblastic lymphoma and peripheral blood eosinophilia are reported. At the time of diagnosis, all patients had lymphadenopathy, and one had a mediastinal mass. Lymph node biopsies revealed lymphoblastic lymphoma admixed with a variable number of mature eosinophils. Immunophenotypic studies demonstrated that each lymphoma had an immature T- cell immunophenotype. Bone marrow biopsies were hypercellular with myeloid hyperplasia and eosinophilia but were negative for lymphoma. All patients received multiagent chemotherapy; one patient achieved a complete remission, and two patients had partial remissions. All patients subsequently developed a myeloid malignancy. Two died of acute myeloid leukemia within 18 months of the diagnosis of lymphoblastic lymphoma. The third patient relapsed with a lymphoma that had histologic and immunophenotypic features of both T-cell lymphoblastic lymphoma and granulocytic sarcoma and also developed a poorly defined myeloproliferative disorder. These findings suggest that T-cell lymphoblastic lymphoma associated with eosinophilia may represent a distinct clinicopathologic entity with a high risk of subsequent myeloid neoplasia.

Original languageEnglish
Pages (from-to)236-245
Number of pages10
JournalAmerican Journal of Surgical Pathology
Volume16
Issue number3
DOIs
Publication statusPublished - Jan 1 1992
Externally publishedYes

Fingerprint

T-Cell Lymphoma
Eosinophilia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Neoplasms
Lymphoma
Myeloid Sarcoma
Biopsy
Myeloproliferative Disorders
Eosinophils
Acute Myeloid Leukemia
Hyperplasia
Lymph Nodes
Bone Marrow
T-Lymphocytes
Drug Therapy

Keywords

  • Acute myeloid leukemia
  • Eosinophilia
  • Lymphoblastic lymphoma
  • T-cell immunophenotype

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

T-cell lymphoblastic lymphoma with eosinophilia associated with subsequent myeloid malignancy. / Abruzzo, L. V.; Jaffe, E. S.; Cotelingam, J. D.; Whang-Peng, J.; Del Duca, V.; Medeiros, L. J.

In: American Journal of Surgical Pathology, Vol. 16, No. 3, 01.01.1992, p. 236-245.

Research output: Contribution to journalArticle

Abruzzo, L. V. ; Jaffe, E. S. ; Cotelingam, J. D. ; Whang-Peng, J. ; Del Duca, V. ; Medeiros, L. J. / T-cell lymphoblastic lymphoma with eosinophilia associated with subsequent myeloid malignancy. In: American Journal of Surgical Pathology. 1992 ; Vol. 16, No. 3. pp. 236-245.
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AB - Three patients with T-cell lymphoblastic lymphoma and peripheral blood eosinophilia are reported. At the time of diagnosis, all patients had lymphadenopathy, and one had a mediastinal mass. Lymph node biopsies revealed lymphoblastic lymphoma admixed with a variable number of mature eosinophils. Immunophenotypic studies demonstrated that each lymphoma had an immature T- cell immunophenotype. Bone marrow biopsies were hypercellular with myeloid hyperplasia and eosinophilia but were negative for lymphoma. All patients received multiagent chemotherapy; one patient achieved a complete remission, and two patients had partial remissions. All patients subsequently developed a myeloid malignancy. Two died of acute myeloid leukemia within 18 months of the diagnosis of lymphoblastic lymphoma. The third patient relapsed with a lymphoma that had histologic and immunophenotypic features of both T-cell lymphoblastic lymphoma and granulocytic sarcoma and also developed a poorly defined myeloproliferative disorder. These findings suggest that T-cell lymphoblastic lymphoma associated with eosinophilia may represent a distinct clinicopathologic entity with a high risk of subsequent myeloid neoplasia.

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