Systemic inflammatory response syndrome is an independent predictor of one-year mortality in patients with acute myocardial infarction

Wei Chieh Huang, Ruey Hsing Chou, Chun Chin Chang, Chien-Yu Hsu, Yuchen Ku, Hsiufen Huang, Yichieh Chen, Po Hsun Huang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Convincing evidence suggests that inflammatory biomarkers are associated with an increased risk among patients with acute myocardial infarction (AMI). However, the impact of systemic inflammatory response (SIRS) on one-year clinical outcomes remains uncertain. Herein we investigated the impact of SIRS on one-year mortality and major adverse cardiovascular events (MACE) in patients with AMI. Methods: We conducted a retrospective study that enrolled patients admitted due to AMI and who received coronary artery intervention from January 2012 to June 2014. SIRS was defined according to standard criteria as having two or more of the following: (1) body temperature < 36 or > 38 °C, (2) heart rate > 90 beats per minute, (3) respiratory rate > 20, or (4) white blood cell count < 4000/mm3 or > 12,000/mm3. The primary endpoint was one-year mortality. The secondary endpoint was a one-year MACE, including revascularization, AMI, and stroke. Results: A total of 330 AMI patients were enrolled in the study, and 121 study subjects (36.6%) met the SIRS criteria. AMI patients with SIRS on admission had significantly increased one-year all-cause mortality (control vs. SIRS: 21.1% vs. 33.1%, p = 0.026) and one-year MACE (35.9% vs. 53.7%, p = 0.022). Patients with SIRS had a higher incidence of one-year non-fatal myocardial infarction, but not non-fatal stroke. After multivariable adjustment, SIRS [hazard ratio (HR) = 1.773, 95% confidence interval (CI) = 1.097-2.886, p = 0.019] and age (HR = 1.038, 95% CI = 1.018-1.058, p < 0.001) were associated with enhanced risk of one-year mortality. Conclusions: This study revealed that AMI patients with SIRS on initial admission were associated with increased risk of one-year all-cause mortality. © 2017, Republic of China Society of Cardiology. All rights reserved.
Original languageEnglish
Pages (from-to)477-485
Number of pages9
JournalActa Cardiologica Sinica
Volume33
Issue number5
DOIs
Publication statusPublished - 2017
Externally publishedYes

Fingerprint

Systemic Inflammatory Response Syndrome
Myocardial Infarction
Mortality
Stroke
Confidence Intervals
Respiratory Rate
Cardiology
Body Temperature
Taiwan
Leukocyte Count
Coronary Vessels
Retrospective Studies
Biomarkers
Heart Rate
Incidence

Keywords

  • Myocardial infarction
  • Systemic inflammatory response syndrome
  • acute heart infarction
  • aged
  • Article
  • atherosclerosis
  • body temperature
  • brain ischemia
  • breathing rate
  • clinical outcome
  • congestive heart failure
  • creatinine blood level
  • diabetes mellitus
  • electrocardiogram
  • follow up
  • heart infarction
  • heart left ventricle ejection fraction
  • human
  • inflammation
  • laboratory test
  • leukocyte
  • leukocyte count
  • long term care
  • major clinical study
  • male
  • mortality
  • retrospective study
  • systemic inflammatory response syndrome
  • target vessel revascularization

Cite this

Systemic inflammatory response syndrome is an independent predictor of one-year mortality in patients with acute myocardial infarction. / Huang, Wei Chieh; Chou, Ruey Hsing; Chang, Chun Chin; Hsu, Chien-Yu; Ku, Yuchen; Huang, Hsiufen; Chen, Yichieh; Huang, Po Hsun.

In: Acta Cardiologica Sinica, Vol. 33, No. 5, 2017, p. 477-485.

Research output: Contribution to journalArticle

Huang, Wei Chieh ; Chou, Ruey Hsing ; Chang, Chun Chin ; Hsu, Chien-Yu ; Ku, Yuchen ; Huang, Hsiufen ; Chen, Yichieh ; Huang, Po Hsun. / Systemic inflammatory response syndrome is an independent predictor of one-year mortality in patients with acute myocardial infarction. In: Acta Cardiologica Sinica. 2017 ; Vol. 33, No. 5. pp. 477-485.
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abstract = "Background: Convincing evidence suggests that inflammatory biomarkers are associated with an increased risk among patients with acute myocardial infarction (AMI). However, the impact of systemic inflammatory response (SIRS) on one-year clinical outcomes remains uncertain. Herein we investigated the impact of SIRS on one-year mortality and major adverse cardiovascular events (MACE) in patients with AMI. Methods: We conducted a retrospective study that enrolled patients admitted due to AMI and who received coronary artery intervention from January 2012 to June 2014. SIRS was defined according to standard criteria as having two or more of the following: (1) body temperature < 36 or > 38 °C, (2) heart rate > 90 beats per minute, (3) respiratory rate > 20, or (4) white blood cell count < 4000/mm3 or > 12,000/mm3. The primary endpoint was one-year mortality. The secondary endpoint was a one-year MACE, including revascularization, AMI, and stroke. Results: A total of 330 AMI patients were enrolled in the study, and 121 study subjects (36.6{\%}) met the SIRS criteria. AMI patients with SIRS on admission had significantly increased one-year all-cause mortality (control vs. SIRS: 21.1{\%} vs. 33.1{\%}, p = 0.026) and one-year MACE (35.9{\%} vs. 53.7{\%}, p = 0.022). Patients with SIRS had a higher incidence of one-year non-fatal myocardial infarction, but not non-fatal stroke. After multivariable adjustment, SIRS [hazard ratio (HR) = 1.773, 95{\%} confidence interval (CI) = 1.097-2.886, p = 0.019] and age (HR = 1.038, 95{\%} CI = 1.018-1.058, p < 0.001) were associated with enhanced risk of one-year mortality. Conclusions: This study revealed that AMI patients with SIRS on initial admission were associated with increased risk of one-year all-cause mortality. {\circledC} 2017, Republic of China Society of Cardiology. All rights reserved.",
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author = "Huang, {Wei Chieh} and Chou, {Ruey Hsing} and Chang, {Chun Chin} and Chien-Yu Hsu and Yuchen Ku and Hsiufen Huang and Yichieh Chen and Huang, {Po Hsun}",
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TY - JOUR

T1 - Systemic inflammatory response syndrome is an independent predictor of one-year mortality in patients with acute myocardial infarction

AU - Huang, Wei Chieh

AU - Chou, Ruey Hsing

AU - Chang, Chun Chin

AU - Hsu, Chien-Yu

AU - Ku, Yuchen

AU - Huang, Hsiufen

AU - Chen, Yichieh

AU - Huang, Po Hsun

N1 - 引用次數:3 Export Date: 18 September 2018 CODEN: CKHCE 通訊地址: Chou, R.-H.; Division of Cardiology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taiwan; 電子郵件: s19101081@yahoo.com.tw

PY - 2017

Y1 - 2017

N2 - Background: Convincing evidence suggests that inflammatory biomarkers are associated with an increased risk among patients with acute myocardial infarction (AMI). However, the impact of systemic inflammatory response (SIRS) on one-year clinical outcomes remains uncertain. Herein we investigated the impact of SIRS on one-year mortality and major adverse cardiovascular events (MACE) in patients with AMI. Methods: We conducted a retrospective study that enrolled patients admitted due to AMI and who received coronary artery intervention from January 2012 to June 2014. SIRS was defined according to standard criteria as having two or more of the following: (1) body temperature < 36 or > 38 °C, (2) heart rate > 90 beats per minute, (3) respiratory rate > 20, or (4) white blood cell count < 4000/mm3 or > 12,000/mm3. The primary endpoint was one-year mortality. The secondary endpoint was a one-year MACE, including revascularization, AMI, and stroke. Results: A total of 330 AMI patients were enrolled in the study, and 121 study subjects (36.6%) met the SIRS criteria. AMI patients with SIRS on admission had significantly increased one-year all-cause mortality (control vs. SIRS: 21.1% vs. 33.1%, p = 0.026) and one-year MACE (35.9% vs. 53.7%, p = 0.022). Patients with SIRS had a higher incidence of one-year non-fatal myocardial infarction, but not non-fatal stroke. After multivariable adjustment, SIRS [hazard ratio (HR) = 1.773, 95% confidence interval (CI) = 1.097-2.886, p = 0.019] and age (HR = 1.038, 95% CI = 1.018-1.058, p < 0.001) were associated with enhanced risk of one-year mortality. Conclusions: This study revealed that AMI patients with SIRS on initial admission were associated with increased risk of one-year all-cause mortality. © 2017, Republic of China Society of Cardiology. All rights reserved.

AB - Background: Convincing evidence suggests that inflammatory biomarkers are associated with an increased risk among patients with acute myocardial infarction (AMI). However, the impact of systemic inflammatory response (SIRS) on one-year clinical outcomes remains uncertain. Herein we investigated the impact of SIRS on one-year mortality and major adverse cardiovascular events (MACE) in patients with AMI. Methods: We conducted a retrospective study that enrolled patients admitted due to AMI and who received coronary artery intervention from January 2012 to June 2014. SIRS was defined according to standard criteria as having two or more of the following: (1) body temperature < 36 or > 38 °C, (2) heart rate > 90 beats per minute, (3) respiratory rate > 20, or (4) white blood cell count < 4000/mm3 or > 12,000/mm3. The primary endpoint was one-year mortality. The secondary endpoint was a one-year MACE, including revascularization, AMI, and stroke. Results: A total of 330 AMI patients were enrolled in the study, and 121 study subjects (36.6%) met the SIRS criteria. AMI patients with SIRS on admission had significantly increased one-year all-cause mortality (control vs. SIRS: 21.1% vs. 33.1%, p = 0.026) and one-year MACE (35.9% vs. 53.7%, p = 0.022). Patients with SIRS had a higher incidence of one-year non-fatal myocardial infarction, but not non-fatal stroke. After multivariable adjustment, SIRS [hazard ratio (HR) = 1.773, 95% confidence interval (CI) = 1.097-2.886, p = 0.019] and age (HR = 1.038, 95% CI = 1.018-1.058, p < 0.001) were associated with enhanced risk of one-year mortality. Conclusions: This study revealed that AMI patients with SIRS on initial admission were associated with increased risk of one-year all-cause mortality. © 2017, Republic of China Society of Cardiology. All rights reserved.

KW - Myocardial infarction

KW - Systemic inflammatory response syndrome

KW - acute heart infarction

KW - aged

KW - Article

KW - atherosclerosis

KW - body temperature

KW - brain ischemia

KW - breathing rate

KW - clinical outcome

KW - congestive heart failure

KW - creatinine blood level

KW - diabetes mellitus

KW - electrocardiogram

KW - follow up

KW - heart infarction

KW - heart left ventricle ejection fraction

KW - human

KW - inflammation

KW - laboratory test

KW - leukocyte

KW - leukocyte count

KW - long term care

KW - major clinical study

KW - male

KW - mortality

KW - retrospective study

KW - systemic inflammatory response syndrome

KW - target vessel revascularization

U2 - 10.6515/ACS20170603A

DO - 10.6515/ACS20170603A

M3 - Article

VL - 33

SP - 477

EP - 485

JO - Acta Cardiologica Sinica

JF - Acta Cardiologica Sinica

SN - 1011-6842

IS - 5

ER -